CHARACTERISTIC OF AGE-DEPENDENT CHANGES IN PIAL ARTERIAL VESSELS ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

2020 ◽  
pp. 663-672
Author(s):  
О. П. Горшкова
Keyword(s):  
Small Diameter ◽  
Shr Rats ◽  
Hypertensive Rats ◽  
Synthesis System ◽  
Spontaneously Hypertensive ◽  
Small Vessels ◽  
Age Dependent ◽  
Calcium Activated Potassium Channels ◽  
Pial Arterial Vessels

Изучено изменение роли эндотелиальной гиперполяризации ( EDH ) в эндотелий-зависимой регуляции тонуса мозговых сосудов при старении в отсутствии и в условиях длительно текущей артериальной гипертензии (АГ). Исследовали роль EDH , индуцируемой активацией IK -каналов, и NO в дилатации пиальных артериальных сосудов на ацетилхолин у нормотензивных ( WKY ) и спонтанно гипертензивных крыс ( SHR ) в возрасте 4 и 18 мес. Установлено, что у крыс WKY механизм EDH преимущественно выражен в группе мелких сосудов. В процессе старения происходит снижение вклада EDH в осуществление дилатации мелких и средних сосудов с одновременным его повышением у артерий диаметром более 40 мкм. АГ приводит к повышению вклада процессов EDH в дилатацию сосудов мелкого и среднего диаметра. Старение, сопровождаемое длительно текущей АГ, снижает вклад EDH в дилатацию. У 18-месячных крыс SHR этот механизм выражен только в группе мелких сосудов диаметром менее 20 мкм. В основе возрастных изменений роли механизмов EDH в дилататорных ответах сосудов у крыс WKY и SHR лежит нарушение системы синтеза NO и изменение роли NO -опосредованных механизмов в эндотелийзависимой вазодилатации. A comparative study of changes in the contribution of endothelium-dependent hyperpolarization (EDH) induced by activation of the intermediate-conductance calcium-activated potassium channels ( IK ) channels and the contribution of NO in pial arterial vessels dilation to acetylcholine (ACh) in normotensive ( WKY ) and spontaneously hypertensive ( SHR ) rats at the age of 4 and 18 months was conducted. It was found that in WKY , the EDH is mainly expressed in the group of small pial arterial vessels. During aging, the contribution of EDH to the dilatation of small (diameter less than 20 microns) and medium (20-40 microns) vessels decreases, while it increases in arteries with a diameter of more than 40 microns. Hypertension (HT) leads to an increase in the contribution of EDH processes to dilation of vessels of small and medium diameters. Aging, accompanied by long-term HT, reduces the contribution of EDH to dilation. In 18-month-old SHR, this mechanism is expressed only in a group of small vessels. Age-dependent changes in the EDH contribution in pial arterial vessels dilation in WKY and SHR rats are based on the NO synthesis system damage and a change in the NO -mediated contribution in endothelium-dependent vasodilation.

scholarly journals Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Gui-Hua Tian ◽  
Kai Sun ◽  
Ping Huang ◽  
Chang-Man Zhou ◽  
Hai-Jiang Yao ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Spontaneously Hypertensive Rats ◽  
Wistar Rats ◽  
Shr Rats ◽  
Hypertensive Rats ◽  
Sham Control ◽  
Spontaneously Hypertensive ◽  
Ca1 Region

This study was designed to investigate the effect of long-term electroacupuncture at Baihui (DU20) and Zusanli (ST36) on cerebral microvessels and neurons in CA1 region of hippocampus in spontaneously hypertensive rats (SHR). A total of 45 male Wistar rats and 45 SHR were randomly grouped, with or without electroacupuncture (EA) at DU20 and ST36, once every other day for a period of 8 weeks. The mean arterial pressure (MAP) was measured once every 2 weeks. Cerebral blood flow (CBF) and the number of open microvessels in hippocampal CA1 region were detected by Laser Doppler and immunohistochemistry, respectively. Nissl staining and Western blotting were performed, respectively, to determine hippocampus morphology and proteins that were implicated in the concerning signaling pathways. The results showed that the MAP in SHR increased linearly over the observation period and was significantly reduced following electroacupuncture as compared with sham control SHR rats, while no difference was observed in Wistar rats between EA and sham control. The CBF, learning and memory capacity, and capillary rarefaction of SHR were improved by EA. The upregulation of angiotensin II type I receptor (AT1R), endothelin receptor (ETAR), and endothelin-1 (ET-1) in SHR rats was attenuated by electroacupuncture, suggesting an implication of AT1R, ETAR, and ET-1 pathway in the effect of EA.

Long-term administration of prazosin improves bladder storage function: Results from a study in spontaneously hypertensive rats

2011 ◽  
Vol 18 (11) ◽  
pp. 785-791 ◽  
Author(s):  
Nobuhiro Haga ◽  
Ken Aikawa ◽  
Kei Ishibashi ◽  
Tomohiko Yanagida ◽  
Masanori Nomiya ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Storage Function ◽  
Term Administration

scholarly journals Effects of L-arginine oral supplements in pregnant spontaneously hypertensive rats

2006 ◽  
Vol 21 (4) ◽  
pp. 192-196 ◽  
Author(s):  
José Ricardo Sousa Ayres de Moura ◽  
Nelson Sass ◽  
Sérgio Botelho Guimarães ◽  
Paulo Roberto Leitão de Vasconcelos ◽  
Rosiane Mattar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Statistical Significance ◽  
Virgin Female ◽  
Female Rats ◽  
Vaginal Smear ◽  
Shr Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Oral Supplementation

PURPOSE: To evaluate the effects of L-arginine oral supplementation in spontaneously hypertensive pregnant rats (SHR). METHODS: Thirty SHR and ten Wistar-EPM-1 virgin female rats were used in the study. Before randomization, females were caged with males of the same strain (3:1). Pregnancy was confirmed by sperm-positive vaginal smear (Day 0). Wistar-EPM-1 rats served as counterpart control (C-1). SHR rats were randomized in 4 groups (n=10): Group Control 2, non-treated rats; Group L-Arginine treated with L-arginine 2%; Group Alpha-methyldopa treated with Alpha-methyldopa 33mg/Kg; Group L-Arginine+Alpha-methyldopa treated with L-arginine 2%+Alpha-methyldopa 33mg/Kg. L-arginine 2% solution was offered ad libitum in drinking water and Alpha-methyldopa was administered by gavage twice a day during the length of pregnancy (20 days). Blood pressure was measured by tailcuff plethysmography on days 0 and 20. Body weight was measured on days 0, 10 and 20. Results were expressed as mean ± SD (Standard Deviation). One-Way ANOVA/Tukey (or Kruskal-Wallis/Dunn, as appropriate) was used for group comparisons. Statistical significance was accepted as p<0.05. RESULTS: There was no significant weight gain in isolated L-arginine treated SHR. Mean blood pressure decreased in L-arginine-treated SLR compared with untreated-SHR rats. CONCLUSION: L-arginine oral supplementation reduces blood pressure in spontaneously hypertensive rats during pregnancy.

scholarly journals Long‐term Treatment with Kefir Probiotics Ameliorates Cardiac Function in Spontaneously Hypertensive Rats

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Mirian Almeida Silva‐Cutini ◽  
Simone Alves Almeida ◽  
Andrews Marques Nascimento ◽  
Glaucia Rodrigues Abreu ◽  
Nazaré Souza Bissoli ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Spontaneously Hypertensive Rats ◽  
Term Treatment ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Long Term Treatment
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