scholarly journals Orbital apex syndrome secondary to sinonasal diffuse large B cell lymphoma: how rare is it?

2021 ◽  
Vol 3 (3) ◽  
pp. 183-188
Author(s):  
See-Teng Tan ◽  
Nor Binti Tak Akmar ◽  
A/P V.S Menon Sudha
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Cranial Neuropathy ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Tissue Mass ◽  
Large B Cell Lymphoma ◽  
Large B Cell

A sinonasal lymphoma is an uncommon form of non-Hodgkin lymphoma (NHL), comprising only 1.5% of all lymphomas. We report a rare case of primary sinonasal diffuse large B cell lymphoma (DLBCL) found accompanying orbital apex syndrome. A 75-year-old Chinese man presented with progressively reduced visualacuity in the left eye for over 2 months and frequent rhinorrhoea for the previous 4 months. Upon examination, his left eye was noted with poor vision with incomplete ptosis, periorbital fullness, and ophthalmoplegia. Computed tomography scan of the brain and orbit showed nasal soft tissue mass with local extension to the left extraconal space. Histopathological examination of the nasal biopsy tissue showed high-grade DLBCL. The distal cranial neuropathy caused by the lymphomatous infiltration of the left paranasal sinuses had preceded the systemic manifestation. The patient was initiated on chemotherapy and has been, at the time of writing, in remission for 8 months after presentation.

Intravascular large B-cell lymphoma presenting with reticular telangiectasia on the trunk and panhypopituitarism: an autopsy case

2021 ◽  
Vol 14 (3) ◽  
pp. e239422
Author(s):  
Midori Tokushima ◽  
Masaki Tago ◽  
Naoko E Katsuki ◽  
Shu-ichi Yamashita
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Final Diagnosis ◽  
Skin Lesions ◽  
Lower Abdomen ◽  
Large B Cell Lymphoma ◽  
Skin Induration ◽  
Large B Cell

A 75-year-old woman developed redness and swelling on her truncal skin, spreading from the lower abdomen to left thigh, 2 months before being admitted to our hospital. She was urgently hospitalised because of her worsening respiratory condition. On admission, she had reticular telangiectasia, diffuse skin induration on the lower abdomen and panhypopituitarism. She was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by the third random abdominal skin biopsy. After histopathological examination at autopsy, we made a final diagnosis of IVLBCL causing respiratory failure and panhypopituitarism. This is the rare case of IVLBCL-induced panhypopituitarism showing visible skin lesions.

scholarly journals Subcutaneous mass concerning for sarcoma: a peculiar presentation of diffuse large B-cell lymphoma

2019 ◽  
Vol 12 (7) ◽  
pp. e229327
Author(s):  
John Mayo ◽  
Kenneth Bogenberger ◽  
Thomas Raj ◽  
Jeffrey Reha
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Cutaneous Lesion ◽  
B Cell Lymphoma ◽  
Radical Resection ◽  
Tissue Mass ◽  
Large B Cell Lymphoma ◽  
Diffuse B Cell Lymphoma ◽  
Subcutaneous Mass ◽  
Large B Cell

Diffuse large B-cell lymphoma (DLBCL) can present in a number of different ways, including as a primary cutaneous lesion or at various other extranodal sites. However, it is rare for a DLBCL to present as a clinically subcutaneous mass without visible skin changes or nodal involvement. A 36-year-old man presented with a 4×4×1 cm subcutaneous mass to his shoulder with normal overlying skin which had been enlarging over 6 months. Physical exam and imaging together made a strong case for sarcoma, and the patient underwent a radical resection. The final pathological diagnosis returned as a diffuse B-cell lymphoma (germinal centre type). The patient subsequently healed and tolerated chemotherapy well. DLBCL can masquerade as a soft tissue mass at initial presentation. If the diagnosis is not clear, a biopsy should be pursued.

scholarly journals Diffuse large B-cell lymphoma presenting as a sacral tumor

2003 ◽  
Vol 15 (2) ◽  
pp. 1-5 ◽  
Author(s):  
James K. Liu ◽  
Peter Kan ◽  
Meic H. Schmidt
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Radicular Pain ◽  
Tissue Mass ◽  
Large B Cell Lymphoma ◽  
First Case ◽  
Sacral Tumor ◽  
Consolidation Radiotherapy ◽  
Large B Cell

Primary lymphomas of the sacrum are rare tumors, reported only in a few cases in the literature. The authors describe two patients with diffuse large B-cell lymphomas presenting as a sacral tumor. In the first case a 52-year-old man presented with progressive back pain, bilateral radicular pain, and saddle block anesthesia secondary to a lytic, expansile soft-tissue mass. The mass arose from the sacrum and eroded through the right S-1 to S-4 foramina and extended into the epidural space of the spinal canal. On magnetic resonance imaging, the sacral mass enhanced homogeneously with Gd. In the second case a 64-year-old man presented with left-sided radicular pain, paresthesias, and progressive weakness due to a lytic soft-tissue mass in the left sacral ala extending into the left L-5 and S-1 foramina. Metastatic workup in each patient demonstrated unremarkable findings. In both cases, an open biopsy procedure was performed after nondiagnostic examination of needle biopsy samples. Histopathological examination showed evidence consistent with diffuse large B-cell lymphoma in both patients. In the first case the disease was classified as Stage IAE, and the patient subsequently underwent four cycles of cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP)– and rituximab-based chemotherapy followed by consolidation radiotherapy. In the second case the disease was also classified as Stage IAE, and the patient underwent CHOP-based chemotherapy and consolidation radiotherapy. In both cases radiography demonstrated a decrease in size of the sacral lymphomas. The authors review the clinical, radiological, and histological features of sacral lymphomas. Lymphoma should be considered in the differential diagnosis of sacral tumors.

High grade non-germinal centre-like diffuse large B-cell lymphoma double expressor presenting as a hydrocoele

2021 ◽  
Vol 14 (12) ◽  
pp. e247381
Author(s):  
Donnacha Hogan ◽  
Brian Hayes ◽  
Clodagh Keohane ◽  
Derek Barrry Hennessey
Keyword(s):  
Soft Tissue ◽  
B Cell ◽  
Multidisciplinary Team ◽  
Cell Lymphoma ◽  
Soft Tissue Mass ◽  
B Cell Lymphoma ◽  
Preoperative Imaging ◽  
Tissue Mass ◽  
Large B Cell Lymphoma ◽  
Large B Cell

A 72-year-old man was referred to our urology outpatient department with a left hemi-scrotal swelling increasing in size over a matter of weeks, initially suspicious for a left hydrocoele. Initial investigation with ultrasound (US) identified a heterogenous enlargement of the left testis and epididymis with a soft tissue mass extending through the inguinal canal. Subsequent CT detected this soft tissue mass to extend along the left gonadal vein to the level of the left renal vein. A biopsy of the retroperitoneal mass confirmed a diagnosis of diffuse large B-cell lymphoma. Immunohistochemical staining further categorised this lymphoma as double expressor but not double hit.Through multidisciplinary team involvement the patient was treated with combination steroids and chemotherapy. Given the scrotal involvement this was considered a sanctuary site for chemotherapy therefore the patient also received radiotherapy to the scrotum. He recovered well following his treatment. This case highlights how early specialist referral can identify rare variants of disease. Essential preoperative imaging with US prior to treating a presumed hydrocoele prevented inappropriate surgical excision. A multidisciplinary team approach improved the patient’s outcome and is hoped to have improved his chances of recurrence-free survival.

scholarly journals Primary Diffuse Large B Cell Lymphoma Mimicking Hyperplastic Reactive Lesion (Lymphoma of the Oral Cavity)

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Liziane Cattelan Donaduzzi ◽  
Angélica Reinheimer ◽  
Maria Augusta Ramires da Silva ◽  
Lucia de Noronha ◽  
Aline Cristina Batista Rodrigues Johann ◽  
...  
Keyword(s):  
Oral Cavity ◽  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Immunohistochemical Analysis ◽  
Lymphoid Cells ◽  
Anterior Teeth ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Objective. To report a case of a challenging oral diagnosis involving a primary diffuse large B cell lymphoma of the oral cavity mimicking a hyperplastic reactive lesion.Case Report. A 72-year-old male patient was referred to the Department of Stomatology presenting a proliferative nodular lesion in the anterior region of the mandible involving the anterior teeth. The clinical examination revealed anterior teeth affected by periodontal disease, suggesting the nodular cession hyperplastic reaction. Incisional biopsy was performed under local anesthesia. The histopathological examination revealed a diffuse proliferation of atypical large lymphoid cells. The tumor cells showed immunopositivity for CD20 and Ki67 (100%) and negativity for CD3, CD30, and CD15. The diagnosis of diffuse large B cell lymphoma was established. The patient underwent chemotherapy and progressed to death after nine months.Conclusion. Lymphomas of the oral cavity are rare and may have nonspecific clinical features, mimicking inflammatory and reactive lesions. Therefore, a detailed clinical evaluation associated with histopathological and immunohistochemical analysis should be performed to enable early and accurate diagnoses in suspected oral lesions.

scholarly journals A rare case of primary cutaneous diffuse large B cell lymphoma, leg type with metastasis

2021 ◽  
Vol 7 (3) ◽  
pp. 479
Author(s):  
Agni K. Bose ◽  
Pandharinath K. Khade ◽  
Vidya D. Kharkar
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Review Literature ◽  
Lower Limbs ◽  
Aggressive Lymphoma ◽  
Atypical Cell ◽  
Large B Cell Lymphoma ◽  
Large B Cell

<p class="abstract">Primary cutaneous diffuse large B cell lymphoma, leg type (PCDLBCL-LT) is a rare and aggressive type of primary cutaneous B cell lymphoma (PCBCL), which represents 10-20% cases of PCBCL. It has a 40-50% recurrence rate and 5 year survival rate of 50%. Here, we present a case of an 86 year old female who presented to us with complaints of slightly tender annular plaques with an oedematous base present over bilateral lower limbs and pitting oedema. Histopathological examination from the annular lesion showed normal epidermis, grenz zone and a dense lymphoid infiltrate involving almost the entire dermis. Immunohistochemistry confirmed histological findings, atypical cell were positive for CD20 and MUM1 protein with focal expression of BCL 6 which is rare. Based on the above findings, we made a diagnosis of diffuse large B cell lymphoma-leg type and started her on palliative radiotherapy. As PCBCL-LT is rare and aggressive lymphoma, we present this case to review literature and summarise its clinical features.</p>

scholarly journals Diffuse Large B-Cell Lymphoma Discovered following Total Knee Arthroplasty: A Case Report and Literature Review

2021 ◽  
pp. 100-108
Author(s):  
Arvind D. Patil ◽  
Shrihari L. Kulkarni ◽  
Girish Balikai
Keyword(s):  
Total Knee Arthroplasty ◽  
B Cell ◽  
Knee Arthroplasty ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Osteoarthritis Of The Knee ◽  
Large B Cell Lymphoma ◽  
Total Knee ◽  
Large B Cell

Total knee arthroplasty is performed routinely for osteoarthritis of the knee joint. We report a case of high-grade diffuse large B-cell lymphoma as an unexpected diagnosis after histopathological examination of unusual-looking synovium during total knee arthroplasty in a 68-year-old patient without any systemic symptoms.

A case of false identity: Primary cutaneous diffuse large B-cell lymphoma masquerading as Madura Foot

2021 ◽  
pp. 004947552199133
Author(s):  
Sufyan Ibrahim ◽  
Anika Jain ◽  
Kanthilatha Pai
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Knee Amputation ◽  
Large B Cell Lymphoma ◽  
Madura Foot ◽  
Previously Treated ◽  
False Identity ◽  
Large B Cell

Primary cutaneous – diffuse large B-cell lymphoma – leg type (PC-DLBCL-LT) is a less frequent but more aggressive, and potentially curable, type of cutaneous B-cell lymphoma, with intermediate prognosis, that affects elderly individuals. Our patient with indurated, pigmented foot previously treated for Filariasis, now presented with ulcers, multiple discharging sinuses, clinically suspected to have Madura Foot. Histopathological examination confirmed a diagnosis of PC-DLBCL-LT after which he underwent below-knee amputation.

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