Intravascular large B-cell lymphoma presenting with reticular telangiectasia on the trunk and panhypopituitarism: an autopsy case

2021 ◽  
Vol 14 (3) ◽  
pp. e239422
Author(s):  
Midori Tokushima ◽  
Masaki Tago ◽  
Naoko E Katsuki ◽  
Shu-ichi Yamashita
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Final Diagnosis ◽  
Skin Lesions ◽  
Lower Abdomen ◽  
Large B Cell Lymphoma ◽  
Skin Induration ◽  
Large B Cell

A 75-year-old woman developed redness and swelling on her truncal skin, spreading from the lower abdomen to left thigh, 2 months before being admitted to our hospital. She was urgently hospitalised because of her worsening respiratory condition. On admission, she had reticular telangiectasia, diffuse skin induration on the lower abdomen and panhypopituitarism. She was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by the third random abdominal skin biopsy. After histopathological examination at autopsy, we made a final diagnosis of IVLBCL causing respiratory failure and panhypopituitarism. This is the rare case of IVLBCL-induced panhypopituitarism showing visible skin lesions.

scholarly journals Persistence pays: a case of primary cutaneous B-cell lymphoma masked by granulomas

2020 ◽  
Vol 7 (1) ◽  
pp. 126
Author(s):  
Ruple Jairath ◽  
Neil K. Jairath ◽  
Timothy Vandenboom ◽  
Michael T. Goldfarb
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Delayed Diagnosis ◽  
B Cell Lymphoma ◽  
Skin Lesions ◽  
Clonal Proliferation ◽  
Large B Cell Lymphoma ◽  
Initial Biopsy ◽  
Fungal Process ◽  
Large B Cell

<p class="abstract">Primary cutaneous diffuse large B cell lymphoma is a form of cutaneous lymphoma characterized by a clonal proliferation of B cells that is often presents with a delayed diagnosis, and therefore often carries poor prognosis. We report a 77-year-old female presenting with a shin lesion resembling a deep dermal or fungal process. Initial biopsy revealed superficial and deep mixed granulomatous inflammatory infiltrate, which suggested an initial diagnosis of Majocchi’s granuloma, despite negative fungal cultures. Despite treatment, the progressive worsening of the skin lesions prompted multiple repeat biopsies, which eventually revealed CD20, Bcl-2, and Bcl-6 staining, loss of CD3 and CD30, and high Ki67, compatible with a cutaneous high-grade B-cell lymphoma. Clinical presentations of primary cutaneous diffuse large B cell lymphoma can mimic several different clinical entities, rarely including granulomatous disease, such as a fungal pathology. This report highlights the importance of persistence and a multimodal approach to the diagnosis of unidentified skin lesions, especially in the setting of failure to respond to standard therapies.</p>

scholarly journals Primary Diffuse Large B Cell Lymphoma Mimicking Hyperplastic Reactive Lesion (Lymphoma of the Oral Cavity)

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Liziane Cattelan Donaduzzi ◽  
Angélica Reinheimer ◽  
Maria Augusta Ramires da Silva ◽  
Lucia de Noronha ◽  
Aline Cristina Batista Rodrigues Johann ◽  
...  
Keyword(s):  
Oral Cavity ◽  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Immunohistochemical Analysis ◽  
Lymphoid Cells ◽  
Anterior Teeth ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Objective. To report a case of a challenging oral diagnosis involving a primary diffuse large B cell lymphoma of the oral cavity mimicking a hyperplastic reactive lesion.Case Report. A 72-year-old male patient was referred to the Department of Stomatology presenting a proliferative nodular lesion in the anterior region of the mandible involving the anterior teeth. The clinical examination revealed anterior teeth affected by periodontal disease, suggesting the nodular cession hyperplastic reaction. Incisional biopsy was performed under local anesthesia. The histopathological examination revealed a diffuse proliferation of atypical large lymphoid cells. The tumor cells showed immunopositivity for CD20 and Ki67 (100%) and negativity for CD3, CD30, and CD15. The diagnosis of diffuse large B cell lymphoma was established. The patient underwent chemotherapy and progressed to death after nine months.Conclusion. Lymphomas of the oral cavity are rare and may have nonspecific clinical features, mimicking inflammatory and reactive lesions. Therefore, a detailed clinical evaluation associated with histopathological and immunohistochemical analysis should be performed to enable early and accurate diagnoses in suspected oral lesions.

scholarly journals Diffuse Large B Cell Lymphoma with Extensive Cutaneous Relapse

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Umit Yavuz Malkan ◽  
Gursel Gunes ◽  
Okan Yayar ◽  
Haluk Demiroglu
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Skin Lesions ◽  
Salvage Chemotherapy ◽  
Lymph Node Biopsy ◽  
High Grade ◽  
Cutaneous Involvement ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Herein, we aimed to report a diffuse large B cell lymphoma (DLBCL) case that had extensive cutaneous relapse with no skin involvement previously. A 59-year-old man presented to hospital in April 2014 with fatigue, anorexia, fever, and anemia. Cervical lymph node biopsy revealed CD20+, BCL2+, MUM1+, BCL6+ high grade B lymphoproliferative neoplasm. After FISH investigation, he was diagnosed as DLBCL. He was given 7 cycles of R-CHOP and achieved remission. However, in November 2014, he had emerging skin lesions that cover nearly all of his body. A control PET-CT revealed diffuse cutaneous involvement. CD20+, BCL2+, MUM1+, BCL6+ high grade B cell lymphoma infiltration was detected with skin biopsy. He was diagnosed as relapse lymphoma, so 2 cycles of R-DHAP were given. There was no treatment response; therefore, R-ICE regimen was started. The patient had achieved second complete remission and his skin lesions were completely regressed. The involvement of skin with CD20+ cells after 7 cycles of rituximab therapy favors that there is a rituximab resistant disease which tends to involve the skin. To conclude, DLBCL may relapse extensively with cutaneous involvement and the best treatment option in these patients is salvage chemotherapy followed by autologous peripheral blood stem cell transplantation.

scholarly journals A rare case of primary cutaneous diffuse large B cell lymphoma, leg type with metastasis

2021 ◽  
Vol 7 (3) ◽  
pp. 479
Author(s):  
Agni K. Bose ◽  
Pandharinath K. Khade ◽  
Vidya D. Kharkar
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Review Literature ◽  
Lower Limbs ◽  
Aggressive Lymphoma ◽  
Atypical Cell ◽  
Large B Cell Lymphoma ◽  
Large B Cell

<p class="abstract">Primary cutaneous diffuse large B cell lymphoma, leg type (PCDLBCL-LT) is a rare and aggressive type of primary cutaneous B cell lymphoma (PCBCL), which represents 10-20% cases of PCBCL. It has a 40-50% recurrence rate and 5 year survival rate of 50%. Here, we present a case of an 86 year old female who presented to us with complaints of slightly tender annular plaques with an oedematous base present over bilateral lower limbs and pitting oedema. Histopathological examination from the annular lesion showed normal epidermis, grenz zone and a dense lymphoid infiltrate involving almost the entire dermis. Immunohistochemistry confirmed histological findings, atypical cell were positive for CD20 and MUM1 protein with focal expression of BCL 6 which is rare. Based on the above findings, we made a diagnosis of diffuse large B cell lymphoma-leg type and started her on palliative radiotherapy. As PCBCL-LT is rare and aggressive lymphoma, we present this case to review literature and summarise its clinical features.</p>

scholarly journals Orbital apex syndrome secondary to sinonasal diffuse large B cell lymphoma: how rare is it?

2021 ◽  
Vol 3 (3) ◽  
pp. 183-188
Author(s):  
See-Teng Tan ◽  
Nor Binti Tak Akmar ◽  
A/P V.S Menon Sudha
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Cranial Neuropathy ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Tissue Mass ◽  
Large B Cell Lymphoma ◽  
Large B Cell

A sinonasal lymphoma is an uncommon form of non-Hodgkin lymphoma (NHL), comprising only 1.5% of all lymphomas. We report a rare case of primary sinonasal diffuse large B cell lymphoma (DLBCL) found accompanying orbital apex syndrome. A 75-year-old Chinese man presented with progressively reduced visualacuity in the left eye for over 2 months and frequent rhinorrhoea for the previous 4 months. Upon examination, his left eye was noted with poor vision with incomplete ptosis, periorbital fullness, and ophthalmoplegia. Computed tomography scan of the brain and orbit showed nasal soft tissue mass with local extension to the left extraconal space. Histopathological examination of the nasal biopsy tissue showed high-grade DLBCL. The distal cranial neuropathy caused by the lymphomatous infiltration of the left paranasal sinuses had preceded the systemic manifestation. The patient was initiated on chemotherapy and has been, at the time of writing, in remission for 8 months after presentation.

scholarly journals Odontogenic-Like Pain in Partial Edentulism: An Unusual Presentation of Diffuse Large B-Cell Lymphoma of the Mandible

2022 ◽  
Author(s):  
Roberta Catania ◽  
Elena Belloni ◽  
Lorenzo Preda ◽  
Chandra Bortolotto ◽  
Paola Scagnelli ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Final Diagnosis ◽  
Magnetic Resonance Images ◽  
Large B Cell Lymphoma ◽  
Odontogenic Abscess ◽  
Mandibular Body ◽  
The Right ◽  
Large B Cell

AbstractPrimary bone lymphoma is a rare entity and it usually occurs in long bones. Primary mandibular involvement is very rare, and it usually shows unspecific features, mimicking odontogenic inflammatory lesions. We present the unusual case of a diffuse large B-cell lymphoma (DLBCL) of the right mandibular body in a 91-year-old woman, who presented with acute pain in the mandibular region initially suspicious for odontogenic abscess. No significant findings were seen on orthopantomography (OPG) and her almost complete edentulism made the diagnosis of abscess unlikely. Computed tomography and magnetic resonance images showed an expansive mass around the right mandibular body with erosion of cortical bone and involving the right mandibular canal and nerve. Final diagnosis of DLBCL was pathologically proven. The presence of odontogenic-like pain in nearly complete edentulism should be suspicious for malignancy, and it needs further diagnostic workup despite the absence of signs on OPG.

scholarly journals Pulmonary Intravascular B-Cell Lymphoma with Angiotropism/Angioinvasion Mimicking Interstitial Lung Disease: A Clinical Dilemma and Potential Diagnostic Challenge

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Florentina Matea ◽  
Salem Alowami ◽  
Michael Bonert ◽  
Monalisa Sur ◽  
Yaron Shargall ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Skin Lesions ◽  
Lymphoid Cells ◽  
Diagnostic Challenge ◽  
Rare Type ◽  
Large B Cell Lymphoma ◽  
Clinical Dilemma ◽  
Large B Cell

Intravascular large B cell lymphoma (IVLBCL) is a rare type of extranodal diffuse large B-cell lymphoma. Patients typically present with nonspecific findings, particularly bizarre neurologic symptoms, fever, and skin lesions. IVLBCL with primary lung presentation is very rare and difficult to diagnose. The authors report a case of a 75-year-old male who presented with neurological symptoms and showed diffuse pulmonary ground glass opacities on computed tomography scan (CT scan). Surgical lung biopsy was performed. Light microscopic examination of the specimen showed diffuse alveolar septal widening caused by neoplastic lymphocytes, which were positive for CD20. These atypical lymphoid cells also demonstrated angiotropism/angioinvasion of the medium sized pulmonary vessels. The patient was diagnosed with IVLBCL and underwent chemotherapy. The patient is still alive 12 months after diagnosis.

Three Cases of Intravascular Large B-Cell Lymphoma Detected in a Biopsy of Skin Lesions

Dermatology ◽  
2016 ◽  
Vol 232 (2) ◽  
pp. 185-188 ◽  
Author(s):  
Takashi Arai ◽  
Yukihiko Kato ◽  
Maki Funaki ◽  
Sanae Shimamura ◽  
Naoto Yokogawa ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Skin Lesions ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Diffuse Large B-Cell Lymphoma Discovered following Total Knee Arthroplasty: A Case Report and Literature Review

2021 ◽  
pp. 100-108
Author(s):  
Arvind D. Patil ◽  
Shrihari L. Kulkarni ◽  
Girish Balikai
Keyword(s):  
Total Knee Arthroplasty ◽  
B Cell ◽  
Knee Arthroplasty ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Osteoarthritis Of The Knee ◽  
Large B Cell Lymphoma ◽  
Total Knee ◽  
Large B Cell

Total knee arthroplasty is performed routinely for osteoarthritis of the knee joint. We report a case of high-grade diffuse large B-cell lymphoma as an unexpected diagnosis after histopathological examination of unusual-looking synovium during total knee arthroplasty in a 68-year-old patient without any systemic symptoms.

A case of false identity: Primary cutaneous diffuse large B-cell lymphoma masquerading as Madura Foot

2021 ◽  
pp. 004947552199133
Author(s):  
Sufyan Ibrahim ◽  
Anika Jain ◽  
Kanthilatha Pai
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Knee Amputation ◽  
Large B Cell Lymphoma ◽  
Madura Foot ◽  
Previously Treated ◽  
False Identity ◽  
Large B Cell

Primary cutaneous – diffuse large B-cell lymphoma – leg type (PC-DLBCL-LT) is a less frequent but more aggressive, and potentially curable, type of cutaneous B-cell lymphoma, with intermediate prognosis, that affects elderly individuals. Our patient with indurated, pigmented foot previously treated for Filariasis, now presented with ulcers, multiple discharging sinuses, clinically suspected to have Madura Foot. Histopathological examination confirmed a diagnosis of PC-DLBCL-LT after which he underwent below-knee amputation.

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