MODERN MEDICAL AND SOCIAL ASPECTS OF POPULATION MORTALITY FROM DIGESTIVE DISEASES

Author(s):  
N.V. Nozhkina ◽  
T.V. Zaripova ◽  
E.N. Bessonova

The aim is to assess the current medical and social aspects of mortality due to digestive organs diseases on the example of the Sverdlovsk region. Methods are epidemiological analysis, expert, statistical. Results: mortality rate of the population from the digestive organs diseases in the Sverdlovsk region is characterized by growth dynamics from 71.9 per 100,000 population in 2012 to 83.6 in 2017 and exceeding the average Russian indicators. In the structure of total mortality this cause ranks fourth place (6.0 %) in 2017. The mortality rate from the digestive organs diseases among men is 1.3 times higher than among women, the rural population is 9.1% higher than the urban population. In the age and sex composition of the deceased, the age of 30–69 years (69.2 %) prevails, men accounted for 52.3 %, and among the working age – 72.3 %, in the age of older able – bodied more women – 58.2 %. The structure of death causes is dominated by cirrhosis (33.6 %), alcoholic liver disease (13.8 %), intestinal vascular disease (12.7 %), gastric ulcer and duodenal ulcer (12.2 %), pancreatic disease (9.6 %). At working age, 43.5 % died due to liver cirrhosis, 22.8 % – alcoholic liver disease, 12.8 % – pancreatic disease. Among persons at the age above the working age, the proportion of vascular diseases of the intestine is higher – 21.3 %, gastric ulcer and duodenal ulcer – 15.1 %. According to sociodemographic characteristics, persons with low social status prevailed among those who died of digestive system diseases: primary/secondary vocational education in 47.7 %, 43.5 % without vocational education; 77.5 % did not work at working age. With expert evaluation in 60.3 % of the medical death certificates, design and coding defects were detected.

2020 ◽  
Vol 9 (5) ◽  
pp. 308-316
Author(s):  
Gong Yuruo ◽  
◽  
Shi Dujuan ◽  
Wei Kevin Zhang ◽  
Xinzhou Yang ◽  
...  

Objective: To explore the therapeutic effect of Sedum emarginatum (SE) and its polysaccharide on alcoholic liver disease. Methods: First, we ground fresh SE to obtain homogenate, and then test the effect of SE on a mouse model of acute alcoholic fatty liver disease (AFLD). Kunming female mice were given intragastric administration of alcohol once every 12 hours to induce AFLD, three times in total, and the mice received ethanol and SE at the same time. The mice were sacrificed 4 hours after the last alcohol administration, and serum and liver were collected for testing. We found that SE was effective and then carried out subsequent experiments. The dried SE powder was extracted under heating and reflux by different polar solvents: petroleum ether, ethyl acetate, methanol and water. The extracting solution were heat and concentrated to obtain an extract. The water part was purified to obtain polysaccharide. We tested the therapeutic effect of each part of SE in a mouse model of early alcoholic hepatitis (AH). Mice were given 5 g/kg of alcohol every 12 hours, a total of 9 times, and lipopolysaccharide (LPS) was injected intraperitoneally at the 36 h and 84 h. After 4 hours of the last gavage, the mice were sacrificed. The serum and liver tissue were used to tested relevant biochemical indexes. Results: SE had a certain reversal effect on the increase of serum triglycerides caused by alcohol, and it had a better effect on the accumulation of lipid droplets in liver tissues. Oil red O staining proved this result. In the second acute experiment, the mortality rate of the animal in the model group was 7/12, and the mortality rate in each treatment group was 1/8, 1/7, 4/8, and 1/8. In all parts, the crude polysaccharide did not significantly reverse the increase of serum triglyceride levels in early AH, but it could significantly alleviate the increase of inflammatory foci and steatosis in liver tissue. The transmission electron microscopy result indicates that the crude polysaccharide component has a certain protective effect on mitochondrial damage caused by alcohol. Conclusion: SE can reduce fatty liver and hyperlipidemia caused by alcohol, and its polysaccharide can reduce liver inflammation in the early alcoholic hepatitis by protecting mitochondron.


Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.


2001 ◽  
Vol 120 (5) ◽  
pp. A117-A117
Author(s):  
K DEAR ◽  
M BRADLEY ◽  
K MCCORMACK ◽  
R PECK ◽  
D GLEESON

2001 ◽  
Vol 120 (5) ◽  
pp. A116-A116
Author(s):  
H SCHLEMMER ◽  
T SAWATZKI ◽  
I DORNACHER ◽  
S SAMMET ◽  
M HELLENSCHMIDT ◽  
...  

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
S Mueller ◽  
G Millonig ◽  
S Friedrich ◽  
F Stickel ◽  
T Longerich ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document