Anatomical Features of Abdominal Aortic Aneurysm on CT Angiography: A Comparison Study

2021 ◽  
Vol 104 (9) ◽  
pp. 1535-1541
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Ct Angiography ◽  
Smoking Status ◽  
Aortic Diameter ◽  
Morphological Data ◽  
Neck Length ◽  
Lower Systolic Blood Pressure ◽  
Abdominal Aortic ◽  
Aneurysmal Neck

Background: There is little information about the anatomical characteristics and relationship between ruptured and unruptured abdominal aortic aneurysm (AAA). Objective: The present study was to determine the anatomical differences between the two groups as assessed with multi-detector computed tomographic angiography (CTA). Materials and Methods: A retrospective review of all the patients diagnosed with AAA that underwent CTA before aortic repair were performed with matching between ruptured and unruptured groups for age and gender. Patient characteristics, and morphological data of aneurysmal and non-aneurysmal parts on CTA images were reviewed. Results: Ninety-six patients in each group were matched. The ruptured group had significantly lower systolic blood pressure (p=0.027), and higher blood creatinine (p=0.006). In the aneurysm part, maximal aneurysmal diameter was significantly larger in the ruptured group at 7.8 cm versus 6 cm (p<0.001), as well as the larger lumen diameter (p=0.006), longer aneurysmal length (p=0.005), shorter aneurysmal neck length (p=0.009), and thicker maximal thrombus thickness (p<0.001). In the non-aneurysmal part, the aortic diameter of the ruptured group was significantly larger in every location. Multivariate analysis indicated that maximal aneurysmal diameter, non-aneurysmal part of the infrarenal aortic diameter, aneurysmal neck length, and current smoking status remained significant variables for ruptured AAAs. Conclusion: Ruptured AAAs had shorter aneurysmal neck length and larger diameter of both aneurysmal and non-aneurysmal parts of AAA than unruptured group. Keywords: Abdominal aortic aneurysm; CT angiography

Complete pre-operative imaging assessment of abdominal aortic aneurysm with spiral CT angiography

1997 ◽  
Vol 52 (5) ◽  
pp. 369-377 ◽  
Author(s):  
M.L. Errington ◽  
J.M. Ferguson ◽  
I.N. Gillespie ◽  
H.M. Connell ◽  
C.V. Ruckley ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Ct Angiography ◽  
Spiral Ct ◽  
Abdominal Aortic ◽  
Spiral Ct Angiography

scholarly journals Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men

2012 ◽  
Vol 166 (2) ◽  
pp. 191-197 ◽  
Author(s):  
Bu B Yeap ◽  
S A Paul Chubb ◽  
Kieran A McCaul ◽  
Leon Flicker ◽  
Ken K Y Ho ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Binding Proteins ◽  
Older Men ◽  
Community Dwelling ◽  
Aortic Diameter ◽  
Aortic Dilation ◽  
Cross Sectional ◽  
Gh Secretion ◽  
Abdominal Aortic

ObjectiveAbdominal aortic aneurysm (AAA) is most prevalent in older men. GH secretion declines with age resulting in reduced IGF1 levels. IGF1 and its binding proteins (IGFBPs) are expressed in vasculature, and lower IGF1 levels have been associated with cardiovascular risk factors and disease. However, the relationship of the IGF1 system with aortic dilation and AAA is unclear. We tested the hypothesis that circulating IGF1 and IGFBPs are associated with AAA and aortic diameter in older men.DesignA cross-sectional analysis involving 3981 community-dwelling men aged 70–89 years was performed.MethodsAbdominal aortic diameter was measured by ultrasound. Plasma total IGF1, IGFBP1 and IGFBP3 were measured by immunoassays.ResultsAfter adjustment for age, body mass index, waist:hip ratio, smoking, hypertension, dyslipidemia, diabetes, coronary heart disease and serum creatinine, a higher IGF1 level was associated with AAA (odds ratio (OR)/1 s.d. increase 1.18, 95% confidence interval (CI) 1.05–1.33, P=0.006), as was the ratio of IGF1/IGFBP3 (OR=1.22, 95% CI 1.10–1.35, P<0.001). Highest IGF1 concentrations compared with lowest quintile were significantly associated with AAA (quintile (Q) 5 vs Q1: OR=1.80, 95% CI 1.20–2.70, P=0.004) as were IGF1/IGFBP3 ratios (Q5 vs Q1: OR=2.52, 95% CI 1.59–4.02, P<0.001). IGF1 and IGFBP1 were independently associated with aortic diameter (β=0.200, 95% CI 0.043–0.357, P=0.012 and β=0.274, 95% CI 0.098–0.449, P=0.002 respectively).ConclusionsIn older men, higher IGF1 and an increased ratio of IGF1/IGFBP3 are associated with AAA, while IGFBP1 is independently associated with increased aortic diameter. Components of the IGF1 system may contribute to, or be a marker for, aortic dilation in ageing men.

Abstract P440: Diabetes and the Long-term Risk of Abdominal Aortic Aneurysm: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Kunihiro Matsushita
Keyword(s):  
Blood Pressure ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Lower Risk ◽  
Aortic Diameter ◽  
Time Varying ◽  
Glycemic Status ◽  
Duration Of Diabetes ◽  
Abdominal Aortic ◽  
Cumulative Duration

Introduction: Diabetes mellitus is known to be related to lower risk of abdominal aortic aneurysm (AAA). However, the full spectrum of glycemic status including prediabetes and the duration of diabetes have not been extensively investigated in the context of AAA risk. Methods: We prospectively studied incident AAA (defined using outpatient records, hospitalization discharge, or death certificate) according to the baseline glycemic status defined using physician diagnosed diabetes, self-reported anti-diabetic medication use and glucose or hemoglobin A1c (diabetes, pre-diabetes, vs. normal glycemia) in 13,116 participants (1990-1992) and the time-varying exposure of duration of incident diabetes in 11,675 participants (1987-1989) using Cox models. We cross-sectionally explored ultrasound-based abdominal aortic diameter by glycemic status and cumulative duration of diabetes in 4,710 participants (2011-2013) using linear regression models. Results: There were 489 incident AAA cases during a median follow-up of ~20 years. Diabetes but not pre-diabetes (vs. normal glycemia) at baseline was independently associated with lower risk of AAA (HR: 0.71 [95%CI 0.51 - 0.99]). The association was largely driven by long-standing diabetes (≥10 years duration: HR: 0.58 [95%CI 0.38 - 0.87]). Longer duration of diabetes was associated with lower risk of AAA (Figure 1A), with 30-50% lower risk in 8 years after incident diabetes diagnosis, as well as smaller aortic diameter measured cross-sectionally (Figure 1B) compared to non-diabetes. Pre-diabetes consistently showed relatively greater diameter (e.g., +0.26 mm [-0.03, +0.54]). Conclusions: Diabetes (but not prediabetes) and its longer duration were independently associated with lower risk of AAA and smaller aortic diameter. Our findings suggest that the cumulative effects of hyperglycemia may play a role in the counterintuitively lower AAA risk. Reduced aortic diameter might be a structural mechanism of decreased AAA risk in diabetes. Figure 1A. Adjusted hazard ratio of incident AAA according to the duration of diabetes among incident cases as a time-varying exposure; Figure 1B. Adjusted difference in maximum diameter (mm) for diabetes vs. non-diabetes by cumulative duration of diabetes. Both models adjusted for age, sex, race, education, BMI, height, total cholesterol, HDL cholesterol, systolic blood pressure, diastolic blood pressure, anti-hypertensive medication, cholesterol-lowering medication, cigarette smoking pack-years, alcohol drinking, eGFR, prevalent peripheral artery disease, prevalent coronary heart disease, and prevalent stroke (time-varying covariates for Figure 1A and baseline covariates for Figure 1B).

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