Study the prevalence of mecA gene in methicillin resistance staphylococcus aureus (MRSA) isolated from different clinical specimens and their antibiotic resistance profile

Background: Evaluating the antibiotic susceptibility and resistance genes is essential in the clinical management of bloodstream infections (BSIs). Nevertheless, there are still limited studies in Northern Vietnam. AIM: This study aimed to determine the antibiotic resistance profile and methicillin-resistant encoding genes of Staphylococcus aureus (S. aureus) causing BSIs in Northern Vietnam. METHODS: The cross-sectional study was done from December 2012 to June 2014 in two tertiary hospitals in Northern Vietnam. Tests performed at the lab of the hospital. RESULTS: In 43 S. aureus strains isolating, 53.5 % were MRSA. Distribution of gene for overall, MRSA, and MSSA strains were following: mecA gene (58.1 %; 95.7%, and 15%), femA gene (48.8%, 47.8%, and 50%), femB gene (88.4%, 82.6%, and 95%). Antibiotic resistance was highest in penicillin (100%), followed by erythromycin (65.1%) and clindamycin (60.5%). Several antibiotics were susceptible (100%), including vancomycin, tigecycline, linezolid, quinupristin/dalfopristin. Quinolone group was highly sensitive, include ciprofloxacin (83.7%), levofloxacin (86%) and moxifloxacin (86%). CONCLUSION: In S. aureus causing BSIs, antibiotic resistance was higher in penicillin, erythromycin, and clindamycin. All strains were utterly susceptible to vancomycin, tigecycline, linezolid, quinupristin/dalfopristin.

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Prevalence and antibiotic resistance profile of Staphylococcus aureus and Eschericia coli among patients attending urology clinic of Dalhatu Araf specialist hospital (DASH) Lafia, Nasarawa State, Nigeria

Bayero Journal of Pure and Applied Sciences ◽

10.4314/bajopas.v13i1.12 ◽

2021 ◽

Vol 13 (1) ◽

pp. 80-89

Author(s):

F.N. Joseph ◽

A.S. Ramalan ◽

M.C. Owoseni ◽

Y. Ya 'aba ◽

A. Chuku

Keyword(s):

Staphylococcus Aureus ◽

Antibiotic Resistance ◽

Resistance Profile ◽

Antibiotic Resistance Profile ◽

Urology Clinic

No abstract.

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A comparative characterization of nasal and clinical isolates of Staphylococcus aureus from west of Iran

Iranian Journal of Microbiology ◽

10.18502/ijm.v13i6.8086 ◽

2021 ◽

Author(s):

Gholamreza Goudarzi ◽

Yaser Hasanvand ◽

Faranak Rezaei ◽

Somayeh Delfani

Keyword(s):

Staphylococcus Aureus ◽

Antibiotic Resistance ◽

Healthcare Workers ◽

Meca Gene ◽

Staphylococcal Enterotoxin ◽

Healthcare Personnel ◽

Clinical Samples ◽

Resistance Pattern ◽

Clinical Specimens ◽

Significant Difference

Background and Objectives: Recently, the rise of methicillin-resistant Staphylococcus aureus (MRSA) isolated from hos- pital healthcare workers (HCWs) and various infectious samples has become one of the main concerns in hospital settings. Therefore, epidemiological studies are necessary to monitor antibiotic resistance patterns in each region and to study the pathogenesis of this strain to control infections. Materials and Methods: In this cross-sectional study, a total of 100 S. aureus isolates, including 50 isolates obtained from the anterior nares of healthcare workers, as well as 50 other isolates cultured from the various clinical specimens from the referral hospitals in Khorramabad (West of Iran) were tested. All isolates were examined to determine antibiotic resistance pattern, and the presence of staphylococcal enterotoxin A (sea), staphylococcal enterotoxin B (seb) and mecA genes. Results: The mecA gene was found among 36% (18/50) of the clinical S. aureus isolates (CSIs) and 14% (7/50) of nasal S. aureus isolates (NSIs), with statistically significant difference (X2 = 6.53; p = 0.011). The difference between the frequency rate of sea gene among MRSA strains isolated from clinical specimens (46.6%, 7/15) was significant compared to strains isolated from nostrils (14.3%, 1/7) (X2 = 3.85; p = 0.049). Conclusion: The frequency of mecA, sea, and seb genes among the clinical samples was more than strains isolated from the nostrils of healthcare personnel.

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