Long-term Effect of Transurethral Resection of Bladder Tumor Combined with Intravesical Instillation of Pirarubicin on Immune Function in Superficial Bladder Cancer

The high incidence of tumor recurrence following transurethral resection (TUR) represents a major problem encountered in the management of bladder cancer. This study examined the efficacy of intravesical chemotherapy in superficial bladder cancer. We retrospectively analyzed 90 Japanese cases with low-grade superficial transitional cell carcinoma (stage T1, grades 1 and 2) who were rendered tumor-free by TURBT (TUR of bladder tumor) and who thereafter were treated with or without intravesical chemotherapy. Among them, instillation was terminated in 2 patients due to adverse effects (severe but reversible chemical cystitis). Remaining 88 patients were divided into 2 groups according to therapy: the TURBT-only group(n=46), defined as patients treated with TURBT alone, and the Instillation group(n=42), defined as patients treated with weekly intravesical instillation therapies using epirubicin plus Ara-C. Recurrence-free rate was significantly higher in the Instillation group than in the TURBT-only group (p=0.02, HR = 0.457). The 5-year recurrence-free rate was 58.5% for the Instillation group and 38.6% for the TURBT-only group. Our instillation schedule represents the most intensive regimen among previously reported therapies and resulted in a 54.3% decrease in incidence of tumor recurrence. We believe that the results of this study could provide useful information on management of bladder cancer.

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The Significance of Simultaneous Transurethral Resection of Bladder Tumor and the Prostate in Patient who have Superficial Bladder Cancer with Bladder Outlet Obstruction

Korean Journal of Urology ◽

10.4111/kju.2008.49.9.791 ◽

2008 ◽

Vol 49 (9) ◽

pp. 791 ◽

Cited By ~ 1

Author(s):

Won Sik Ham ◽

Won Tae Kim ◽

Hyung Jin Jeon ◽

Dong Hoon Lee ◽

Young Deuk Choi

Keyword(s):

Bladder Cancer ◽

Transurethral Resection ◽

Bladder Outlet Obstruction ◽

Bladder Tumor ◽

Superficial Bladder Cancer ◽

Outlet Obstruction

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Adjuvant chemotherapy with early intravesical instillation of Adriamycin and long-term oral administration of 5-fluorouracil in superficial bladder cancer

Cancer Chemotherapy and Pharmacology ◽

10.1007/bf00686938 ◽

1992 ◽

Vol 30 (S1) ◽

pp. S31-S36 ◽

Cited By ~ 4

Author(s):

Toyofumi Ueda ◽

Seiji Naito ◽

Atsushi Iguchi ◽

Kazuyuki Sagiyama ◽

Yukio Osada ◽

...

Keyword(s):

Bladder Cancer ◽

Adjuvant Chemotherapy ◽

Oral Administration ◽

Superficial Bladder Cancer ◽

Intravesical Instillation

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PHASE I PHARMACOKINETIC STUDY OF A SINGLE INTRAVESICAL INSTILLATION OF GEMCITABINE ADMINISTERED IMMEDIATELY AFTER TRANSURETHRAL RESECTION PLUS MULTIPLE RANDOM BIOPSIES IN PATIENTS WITH SUPERFICIAL BLADDER CANCER

The Journal of Urology ◽

10.1097/01.ju.0000131770.14409.7f ◽

2004 ◽

Vol 172 (2) ◽

pp. 485-488 ◽

Cited By ~ 26

Author(s):

JUAN PALOU ◽

ANTONIO CARCAS ◽

JOSE SEGARRA ◽

BLANCA DUQUE ◽

JOSE SALVADOR ◽

...

Keyword(s):

Bladder Cancer ◽

Phase I ◽

Pharmacokinetic Study ◽

Transurethral Resection ◽

Superficial Bladder Cancer ◽

Intravesical Instillation

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Evaluation of miR-146a Urinary Level as a Marker for Recurrence of Superficial Bladder Cancer after Transurethral Resection of Bladder Tumor (TUR-BT)

10.51429/ejmm29319 ◽

2020 ◽

Vol 29 (3) ◽

pp. 145-151

Author(s):

Amany K. Shahat ◽

Rabea G. Omar

Keyword(s):

Bladder Cancer ◽

Cancer Patients ◽

Normal Level ◽

Transurethral Resection ◽

Cancer Biology ◽

Bladder Tumor ◽

Superficial Bladder Cancer ◽

Urine Samples ◽

Superficial Cancer

Background: The most prevalent malignancy affect the urinary system is bladder cancer which exhibits a markedly high recurrence rate. The level of urinary microRNA-146a (miR-146a) was significantly higher in superficial bladder cancer patients, and were decreased to normal range after transurethral resection of the bladder tumor (TUR-BT). Its level was increased again if there is recurrence of the superficial bladder tumor diagnosed by follow up cystoscopy. miR-146 may be a clinically important marker for diagnosis and recurrence of superficial bladder cancer and is used instead of follow up operations as follow up cystoscopy for follow up of recurrence . Objective: our work aims to detect a simple, reliable and noninvasive diagnostic and surveillance methods for follow up of superficial bladder cancer. Methodology: The level of miR-146a in urine of 30 superficial bladder cancer patients was evaluated by quantitative reverse transcription polymerase chain reaction assay using voided urine samples before, after TUR-BT and after 3, 6,9,12 months of resection and compared with the result of follow up cystoscopy. Results: miR-146a was significantly increased in urine samples from patients with superficial cancer bladder than in those from the normal individuals (P <.000). Elevated urinary miR-146a levels in patients with bladder cancer were lowered to the normal level after TUR-BT and increased again in those who have tumor recurrence and remain in a normal level in those who have no recurrence after follow up for 3 ,6, 9,12 months after surgery(P=. 007, P=.000 respectively).Conclusion: Our study concluded that urinary miR-146a may be useful as a novel noninvasive diagnostic and follow up marker, anticancer agent or therapeutic target for superficial cancer bladder, also for increasing our knowledge of cancer biology.

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