Features of the course of chronic spontaneous urticaria in patients with Common variable immune deficiency and hypogammaglobulinemia.

Chronic spontaneous urticaria is a common disease that can be associated with various autoimmune, infectious (viral, bacterial, parasitic) and non-infectious inflammatory diseases, as well as occur in the symptom complex of other diseases, such as primary immunodeficiencies (PID). Currently, data about the features of the course of chronic spontaneous urticaria in patients with PID are accumulating. In this article we present two clinical cases of patients with common variable immune deficiency and one clinical case of a patient with hypogammaglobulinemia, suffering from chronic spontaneous urticaria. The article describes peculiar properties of IVIG replacement therapy at the course of urticaria in these patients. The discussion section presents data from the world literature and offers key provisions for further investigations.

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Common variable immune deficiency in adults: focus on pulmonary complications

Terapevticheskii arkhiv ◽

10.17116/terarkh20178912211-215 ◽

2017 ◽

Vol 89 (12-2) ◽

pp. 211-215

Author(s):

D S Fomina ◽

E N Bobrikova ◽

D O Sinyavkin ◽

V V Parshin

Keyword(s):

Immune Deficiency ◽

Causes Of Death ◽

Inflammatory Diseases ◽

Pulmonary Complications ◽

Adult Patients ◽

Primary Immunodeficiencies ◽

Common Variable Immune Deficiency ◽

Diagnostic Delays ◽

Common Variable ◽

Clinical Cases

Common variable immune deficiency is the most common form of a group of primary immunodeficiencies in adult patients. Pulmonary complications occupy leading positions. It is the development of recurrent bronchopulmonary inflammatory diseases that is considered to be one of the main causes of death and disability in patients with this disease. By presenting two clinical cases with long diagnostic delays, the authors try to attract the attention of specialists of related professions, which will minimize the development of irreversible complications in the patients.

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Clinical and laboratory characteristics of patients with common variable immune deficiency

Health and Ecology Issues ◽

10.51523/2708-6011.2020-17-2-7 ◽

2020 ◽

pp. 52-56

Author(s):

S. S. Prokopovich ◽

I. A. Novikova ◽

A. P. Salivonchik

Keyword(s):

Immune Deficiency ◽

Respiratory Tract ◽

Inflammatory Diseases ◽

Age Groups ◽

Common Variable Immune Deficiency ◽

Immunoglobulin Level ◽

Age Group ◽

Laboratory Parameters ◽

Laboratory Features ◽

Common Variable

Objective: to identify clinical and laboratory features of common variable immune deficiency (CVID) in different age groups of patients. Material and methods. The clinical and anamnestic characteristics of 36 patients (16 men and 20 women) aged 15 to 65 (the average age was 37.0±12.7) diagnosed with CVID were studied. Results. Among the examined patients the disease was manifested at the mature age in 25 people (69.4 %) - the 1st group, while in 11 people (30.5 %) the debut of the disease occurred during childhood (from 4 to 17) - the 2nd group. Among the patients of the first group, the greatest number of cases (10 cases, 40.0 %) was found at the age of 20-30; in the children's age group, the greatest number of cases (8 cases, 72.7%) occurred at the age of 13-17. Non-infectious manifestations were significantly more common in adult patients at the onset of the disease (64 %; χ2 = 15.68; p < 0.001). Infectious and inflammatory diseases of the ENT organs and respiratory tract were observed with the same frequency in both the groups. Children significantly more often than adults (72.7 %; χ2 = 26.6; p < 0.001) observed a deficit in the three classes of immunoglobulins (Ig) (IgA, IgM, and IgG), whereas in patients with CVID manifestation in adulthood, the concentrations of IgA and IgG were mainly reduced, and meanwhile the degree of the decrease in the immunoglobulin level was more pronounced (72.0 %; χ2 = 14.47; p < 0.001). Conclusion. Significant differences in the clinical and laboratory parameters of CVID manifestation in the patients depending on age have been revealed.

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