scholarly journals Corona Virus and the General Adaptation Syndrome

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Lonsdale Derrick
Keyword(s):  
General Adaptation Syndrome ◽  
Corona Virus ◽  
General Adaptation

scholarly journals Selye’s general adaptation syndrome: stress-induced gastro-duodenal ulceration and inflammatory bowel disease

2017 ◽  
Vol 232 (3) ◽  
pp. F1-F5 ◽  
Author(s):  
George Fink
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Experimental Studies ◽  
Peptic Ulceration ◽  
Duodenal Ulceration ◽  
Peptic Ulcers ◽  
General Adaptation Syndrome ◽  
General Adaptation ◽  
Inflammatory Bowel ◽  
H Pylori

Hans Selye in a note to Nature in 1936 initiated the field of stress research by showing that rats exposed to nocuous stimuli responded by way of a ‘general adaptation syndrome’ (GAS). One of the main features of the GAS was the ‘formation of acute erosions in the digestive tract, particularly in the stomach, small intestine and appendix’. This provided experimental evidence for the view based on clinical data that gastro-duodenal (peptic) ulcers could be caused by stress. This hypothesis was challenged by Marshall and Warren’s Nobel Prize (2005)-winning discovery of a causal association between Helicobacter pylori and peptic ulcers. However, clinical and experimental studies suggest that stress can cause peptic ulceration in the absence of H. pylori. Predictably, the etiological pendulum of gastric and duodenal ulceration has swung from ‘all stress’ to ‘all bacteria’ followed by a sober realization that both factors play a role, separately as well as together. This raises the question as to whether stress and H. pylori interact, and if so, how? Stress has also been implicated in inflammatory bowel disease (IBD) and related disorders; however, there is no proof yet that stress is the primary etiological trigger for IBD. Central dopamine mechanisms seem to be involved in the stress induction of peptic ulceration, whereas activation of the sympathetic nervous system and central and peripheral corticotrophin-releasing factor appears to mediate stress-induced IBD.

General Adaptation Syndrome

2020 ◽  
pp. 926-929
Author(s):  
Tavis S. Campbell ◽  
Jillian A. Johnson ◽  
Kristin A. Zernicke
Keyword(s):  
General Adaptation Syndrome ◽  
General Adaptation

General Adaptation Syndrome

2012 ◽  
pp. 360-360
Author(s):  
Peter Wagner ◽  
Frank C. Mooren ◽  
Hidde J. Haisma ◽  
Stephen H. Day ◽  
Alun G. Williams ◽  
...  
Keyword(s):  
General Adaptation Syndrome ◽  
General Adaptation

Comparison of Tissue Respiration in Mice Exposed to Heat and Cold

1958 ◽  
Vol 195 (2) ◽  
pp. 285-287 ◽  
Author(s):  
R. L. Jasper ◽  
M. E. Denison ◽  
M. X. Zarrow ◽  
W. A. Hiestand
Keyword(s):  
Mortality Rate ◽  
Oxygen Uptake ◽  
Adult Male ◽  
Heat Exposure ◽  
Brain Slices ◽  
Tissue Respiration ◽  
Male Mice ◽  
General Adaptation Syndrome ◽  
Liver Slices ◽  
General Adaptation

Oxygen uptake of liver, kidney and brain slices from cold-and heat-exposed adult, male mice was studied using the Warburg constant volume respirometer. In general, oxygen uptake showed certain similarities for both groups. The greatest oxygen increase from the control was observed after 72 hours of cold or heat exposure. For liver slices this was 21 and 6%, respectively; for kidney it was 23 and 27%; and for brain 33 and 31%, respectively. The lowest rate of oxygen uptake was seen after 48 hours of cold or heat exposure. For liver slices this was –27 and 6%; kidney, –7 and +14%; and for brain –10 and –2%, respectively. The mortality rate was increased in the heat-exposed more than in the cold-exposed animals. It is concluded that the response of oxygen uptake of these tissues from animals exposed to these divergent stresses (cold and heat) conforms to the pattern of the General-Adaptation-Syndrome.

The general adaptation syndrome and the diseases of adaptation

1951 ◽  
Vol 10 (5) ◽  
pp. 549-555 ◽  
Author(s):  
Hans Selye
Keyword(s):  
General Adaptation Syndrome ◽  
General Adaptation

General Adaptation Syndrome

BMJ ◽  
1950 ◽  
Vol 2 (4671) ◽  
pp. 164-164 ◽  
Author(s):  
A. P. Meiklejohn
Keyword(s):  
General Adaptation Syndrome ◽  
General Adaptation
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