scholarly journals Primary Prostatic Diffuse Large B-Cell Lymphoma: a Case Report and Literature Review

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Samia Yasmeen ◽  
Waqas Ahmad ◽  
Omer Waqas ◽  
Abdul Hameed
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Early Stage ◽  
Digital Rectal Examination ◽  
B Cell Lymphoma ◽  
Perineal Pain ◽  
Primary Lymphoma ◽  
Abnormal Finding ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Introduction: Primary lymphomas of the prostate are globally rare representing less than 0.1% of all prostatic neoplasms. In this paper we present a case of an early stage diffuse large B-cell lymphoma (DLBCL) of the prostate managed with six cycles of rituximab-based chemotherapy, and review the related literature. Case description: A 32-year-old man presented to our clinic with complaints of difficult urination and perineal pain. An enlarged, hard and nodular prostate was palpable on digital rectal examination. Needle biopsy of the prostate was performed, which revealed diffuse large B-cell non-Hodgkin's lymphoma by immunohistochemical studies. CT scan showed large pelvic mass arising from prostate encasing ureters with bilateral hydronephroureter.  No abnormal finding was seen on abdominal CT and bone marrow histology. Therefore, the disease was classified into the clinical stage IAXE according to Ann Arbor's criteria. The patient achieved complete response (CR) to six cycles of rituximab based combination chemotherapy, R-CHOP with CNS prophylaxis. He remained disease free, until now, 36 months after the end of chemotherapy. Practical Implications: According to the literature, the treatment and prognosis of primary lymphoma of the prostate is the same as that of other nodal lymphomas. Rituximab-based regimen should be considered in the management of prostatic diffuse large B-cell lymphoma.

Primary diffuse large B cell lymphoma of the optic chiasm in an immunocompetent patient

2021 ◽  
Vol 14 (7) ◽  
pp. e243307
Author(s):  
Orlando De Jesus ◽  
Christian Rios-Vicil ◽  
Frances M Gómez-González ◽  
Román Vélez
Keyword(s):  
B Cell ◽  
Clinical Course ◽  
Cell Lymphoma ◽  
Brain Mri ◽  
B Cell Lymphoma ◽  
Optic Chiasm ◽  
Immunocompetent Patient ◽  
Primary Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Primary lymphoma of the visual pathway is rare, especially at the chiasm. Very few cases have been reported. The lesion is frequently confused with an optic–hypothalamic glioma. A 55-year-old man was found disoriented at his home by a friend and evaluated with a brain MRI which demonstrated an expansile mass located at the optic chiasm and hypothalamus level. The principal differential was a high-grade hypothalamic glioma due to the contrast enhancement. A biopsy of the chiasmal lesion was performed. Histological diagnosis of the lesion was compatible with a diffuse large B cell lymphoma. He was started on methotrexate and rituximab; however, his clinical course kept deteriorating, and he died 64 days after his presentation. All prior cases of primary lymphoma of the chiasm are reviewed.

Pitfalls of Frozen Section in Gynecological Pathology: A Rare Case of Ovarian Lymphoma in an HIV-Positive Woman Resembling Dysgerminoma on Frozen Section

2018 ◽  
Vol 27 (4) ◽  
pp. 387-389 ◽  
Author(s):  
Qing Wang ◽  
Raul Rodriguez ◽  
Jenna Z. Marcus ◽  
Lisa Podolsky ◽  
Damali Campbell ◽  
...  
Keyword(s):  
B Cell ◽  
Rare Case ◽  
Cell Lymphoma ◽  
Frozen Section ◽  
B Cell Lymphoma ◽  
Hiv Positive ◽  
Primary Lymphoma ◽  
Positive Woman ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Primary lymphoma of the ovary, particularly in an HIV-positive woman, is exceptionally rare, and ovarian lymphoma may not be considered at the time of intraoperative consultation. In this article, we present a case in an HIV-positive woman thought to be a dysgerminoma at the time of frozen section, but which was found to be a diffuse large B-cell lymphoma of the ovary.

scholarly journals Adjuvant radiotherapy and chemotherapy in early-stage diffuse large B cell lymphoma of head and neck with extranodal involvement

Hematology ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 268-275 ◽  
Author(s):  
Cuiying Peng ◽  
Joshua Ho ◽  
Harrison X. Bai ◽  
Yuqian Huang ◽  
Raymond Y. Huang ◽  
...  
Keyword(s):  
B Cell ◽  
Head And Neck ◽  
Adjuvant Radiotherapy ◽  
Cell Lymphoma ◽  
Early Stage ◽  
B Cell Lymphoma ◽  
Extranodal Involvement ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) for treatment of early-stage gastric diffuse large B-cell lymphoma

2004 ◽  
Vol 15 (7) ◽  
pp. 1086-1090 ◽  
Author(s):  
S. Wöhrer ◽  
A. Püspök ◽  
J. Drach ◽  
M. Hejna ◽  
A. Chott ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Early Stage ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals R-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphoma

Blood ◽  
2018 ◽  
Vol 131 (2) ◽  
pp. 174-181 ◽  
Author(s):  
Thierry Lamy ◽  
Gandhi Damaj ◽  
Pierre Soubeyran ◽  
Emmanuel Gyan ◽  
Guillaume Cartron ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Early Stage ◽  
B Cell Lymphoma ◽  
Limited Stage ◽  
Large B Cell Lymphoma ◽  
Key Points ◽  
Large B Cell

Key Points For early-stage DLBCL, R-CHOP alone is not inferior to R-CHOP followed by RT.

Early-stage diffuse large B-cell lymphoma of the submental region: a case report and review of the literature

Oral Surgery ◽  
2016 ◽  
Vol 10 (1) ◽  
pp. 56-60 ◽  
Author(s):  
R. Patini ◽  
V. Coviello ◽  
M. Riminucci ◽  
A. Corsi ◽  
A. Cicconetti
Keyword(s):  
Case Report ◽  
B Cell ◽  
Cell Lymphoma ◽  
Early Stage ◽  
B Cell Lymphoma ◽  
Review Of The Literature ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Diffuse Large B-Cell Lymphoma of the Cervix Diagnosed on Cervical Screening Cytology

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S97-S97
Author(s):  
Todd Needs ◽  
Peter Bonneau ◽  
Gabriella Cardoza-Favarato
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Cervical Screening ◽  
B Cell Lymphoma ◽  
Inflammatory Cells ◽  
Cervical Cytology ◽  
Primary Lymphoma ◽  
Cell Block ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract Case Presentation Primary lymphoma of the cervix is an uncommon entity and far more rarely diagnosed on routine screening cervical cytology. We present a case of a 38-year-old female with a 1-year history of heavy cyclical menstrual bleeding and interval spotting. She had no other significant past medical or obstetric history. On cervical exam, obscuring blood was noted without distinct abnormalities of the visualized cervix. Pathologic Findings Cervical cytology by ThinPrep (Hologic, Marlborough, MA) liquid-based cytology preparation demonstrated atypical squamous cells of undetermined significance as well as an abundant population of atypical lymphoid-appearing cells. Morphology of this second population was characterized by large cells (2-3 times the size of background inflammatory cells) with high nuclear-to-cytoplasm ratio, vesicular chromatin, occasional nucleoli, marked nuclear membrane irregularities, and scant cytoplasm. A cell block of the specimen was performed and demonstrated a mature but cytologically large and atypical lymphoid population. Immunohistochemistry on the cell block specimen was consistent with a B-cell immunophenotype with strong CD45 and CD20 immunolabeling. Subsequent radiologic workup showed a diffusely enlarged cervix with increased metabolic uptake, as well as bilateral metabolically active pelvic lymph nodes. Conclusion Cervical and endometrial curettings obtained at an outside facility confirmed the diagnosis of lymphoma that was further categorized as diffuse large B-cell lymphoma, germinal center B-cell type. This case highlights an uncommon diagnosis found on screening cervical cytology. It reinforces awareness of the potential for lymphoid neoplasms on cervical cytology and the differential diagnosis associated with such cases.

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