Diffuse Large B-Cell Lymphoma of the Cervix Diagnosed on Cervical Screening Cytology

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S97-S97
Author(s):  
Todd Needs ◽  
Peter Bonneau ◽  
Gabriella Cardoza-Favarato
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Cervical Screening ◽  
B Cell Lymphoma ◽  
Inflammatory Cells ◽  
Cervical Cytology ◽  
Primary Lymphoma ◽  
Cell Block ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract Case Presentation Primary lymphoma of the cervix is an uncommon entity and far more rarely diagnosed on routine screening cervical cytology. We present a case of a 38-year-old female with a 1-year history of heavy cyclical menstrual bleeding and interval spotting. She had no other significant past medical or obstetric history. On cervical exam, obscuring blood was noted without distinct abnormalities of the visualized cervix. Pathologic Findings Cervical cytology by ThinPrep (Hologic, Marlborough, MA) liquid-based cytology preparation demonstrated atypical squamous cells of undetermined significance as well as an abundant population of atypical lymphoid-appearing cells. Morphology of this second population was characterized by large cells (2-3 times the size of background inflammatory cells) with high nuclear-to-cytoplasm ratio, vesicular chromatin, occasional nucleoli, marked nuclear membrane irregularities, and scant cytoplasm. A cell block of the specimen was performed and demonstrated a mature but cytologically large and atypical lymphoid population. Immunohistochemistry on the cell block specimen was consistent with a B-cell immunophenotype with strong CD45 and CD20 immunolabeling. Subsequent radiologic workup showed a diffusely enlarged cervix with increased metabolic uptake, as well as bilateral metabolically active pelvic lymph nodes. Conclusion Cervical and endometrial curettings obtained at an outside facility confirmed the diagnosis of lymphoma that was further categorized as diffuse large B-cell lymphoma, germinal center B-cell type. This case highlights an uncommon diagnosis found on screening cervical cytology. It reinforces awareness of the potential for lymphoid neoplasms on cervical cytology and the differential diagnosis associated with such cases.

Primary diffuse large B cell lymphoma of the optic chiasm in an immunocompetent patient

2021 ◽  
Vol 14 (7) ◽  
pp. e243307
Author(s):  
Orlando De Jesus ◽  
Christian Rios-Vicil ◽  
Frances M Gómez-González ◽  
Román Vélez
Keyword(s):  
B Cell ◽  
Clinical Course ◽  
Cell Lymphoma ◽  
Brain Mri ◽  
B Cell Lymphoma ◽  
Optic Chiasm ◽  
Immunocompetent Patient ◽  
Primary Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Primary lymphoma of the visual pathway is rare, especially at the chiasm. Very few cases have been reported. The lesion is frequently confused with an optic–hypothalamic glioma. A 55-year-old man was found disoriented at his home by a friend and evaluated with a brain MRI which demonstrated an expansile mass located at the optic chiasm and hypothalamus level. The principal differential was a high-grade hypothalamic glioma due to the contrast enhancement. A biopsy of the chiasmal lesion was performed. Histological diagnosis of the lesion was compatible with a diffuse large B cell lymphoma. He was started on methotrexate and rituximab; however, his clinical course kept deteriorating, and he died 64 days after his presentation. All prior cases of primary lymphoma of the chiasm are reviewed.

Pitfalls of Frozen Section in Gynecological Pathology: A Rare Case of Ovarian Lymphoma in an HIV-Positive Woman Resembling Dysgerminoma on Frozen Section

2018 ◽  
Vol 27 (4) ◽  
pp. 387-389 ◽  
Author(s):  
Qing Wang ◽  
Raul Rodriguez ◽  
Jenna Z. Marcus ◽  
Lisa Podolsky ◽  
Damali Campbell ◽  
...  
Keyword(s):  
B Cell ◽  
Rare Case ◽  
Cell Lymphoma ◽  
Frozen Section ◽  
B Cell Lymphoma ◽  
Hiv Positive ◽  
Primary Lymphoma ◽  
Positive Woman ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Primary lymphoma of the ovary, particularly in an HIV-positive woman, is exceptionally rare, and ovarian lymphoma may not be considered at the time of intraoperative consultation. In this article, we present a case in an HIV-positive woman thought to be a dysgerminoma at the time of frozen section, but which was found to be a diffuse large B-cell lymphoma of the ovary.

scholarly journals Primary Prostatic Diffuse Large B-Cell Lymphoma: a Case Report and Literature Review

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Samia Yasmeen ◽  
Waqas Ahmad ◽  
Omer Waqas ◽  
Abdul Hameed
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Early Stage ◽  
Digital Rectal Examination ◽  
B Cell Lymphoma ◽  
Perineal Pain ◽  
Primary Lymphoma ◽  
Abnormal Finding ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Introduction: Primary lymphomas of the prostate are globally rare representing less than 0.1% of all prostatic neoplasms. In this paper we present a case of an early stage diffuse large B-cell lymphoma (DLBCL) of the prostate managed with six cycles of rituximab-based chemotherapy, and review the related literature. Case description: A 32-year-old man presented to our clinic with complaints of difficult urination and perineal pain. An enlarged, hard and nodular prostate was palpable on digital rectal examination. Needle biopsy of the prostate was performed, which revealed diffuse large B-cell non-Hodgkin's lymphoma by immunohistochemical studies. CT scan showed large pelvic mass arising from prostate encasing ureters with bilateral hydronephroureter.  No abnormal finding was seen on abdominal CT and bone marrow histology. Therefore, the disease was classified into the clinical stage IAXE according to Ann Arbor's criteria. The patient achieved complete response (CR) to six cycles of rituximab based combination chemotherapy, R-CHOP with CNS prophylaxis. He remained disease free, until now, 36 months after the end of chemotherapy. Practical Implications: According to the literature, the treatment and prognosis of primary lymphoma of the prostate is the same as that of other nodal lymphomas. Rituximab-based regimen should be considered in the management of prostatic diffuse large B-cell lymphoma.

Cytological diagnosis of diffuse large B-cell lymphoma in vitreous aspiration by cell block cytology preparation

Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S64-S65
Author(s):  
Nantaya Kunatippapong ◽  
Sakda Waraasawapati ◽  
Trai Wongsiri ◽  
Piyapharom Intararawichian ◽  
Piti Ungareewittaya
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cytological Diagnosis ◽  
Cell Block ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Comprehensive Analysis of TP53 Mutation Characteristics and Identification of Patients with Inferior Prognosis and Enhanced Immune Escape in Diffuse Large B Cell Lymphoma

2021 ◽  
Author(s):  
Tingting Zhang ◽  
Yaxiao Lu ◽  
Xia Liu ◽  
Mengmeng Zhao ◽  
Jin He ◽  
...  
Keyword(s):  
B Cell ◽  
Immune Escape ◽  
Cell Lymphoma ◽  
Immune Therapy ◽  
B Cell Lymphoma ◽  
Inflammatory Cells ◽  
Circulating Tumor Dna ◽  
Comprehensive Analysis ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous lymphatic malignancy. The role of TP53 gene alterations in DLBCL remains unclear. Methods: We performed a comprehensive analysis of the genomic characteristics of TP53 through targeted next-generation sequencing (n=176), RNA-sequencing (n=152), and circulating tumor DNA sequencing (n=38). Results: TP53 was frequently mutated in DLBCL; most TP53 mutations occurred in the DNA-binding domain (DBD). However, TP53 alone is insufficient to effectively differentiate the risk of DLBCL, even when only considering mutations in the DBD region. However, CD58 mutations, which are mutually exclusive from TP53 mutations, in combination with TP53 mutations, could significantly differentiate the prognosis of DLBCL. The survival of patients with either one of the mutually exclusive mutation patterns, namely, TP53MUT&CD58WT or TP53WT&CD58MUT, was inferior to those harboring both wild-type TP53 and CD58. Notably, patients with the TP53WT&CD58MUT mutation pattern had the worst outcome and were characterized by an enhanced immune escape, including features such as the abundant infiltration of inflammatory cells and upregulation of inhibitory immunomodulatory molecules; these patients represent the candidate populations for immune therapy. Conclusions: Our findings indicated that the mutation patterns of TP53 and CD58 accurately stratified patients with DLBCL to permit the optional immunotherapy.

scholarly journals NODULE DU SEIN REVELANT UN LYMPHOME PRIMITIF MAMMAIRE: A PROPOS DUN CAS

2020 ◽  
Vol 8 (10) ◽  
pp. 1027-1030
Author(s):  
K. Aboulfath ◽  
N.A. Mohamed Zeine ◽  
N. Mamouni ◽  
S. Errarhay C. Bouchikhi ◽  
A. Banani
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Primary Lymphoma ◽  
Review Of The Literature ◽  
Cell Type ◽  
Large B Cell Lymphoma ◽  
Limited Surgery ◽  
The Central Nervous System ◽  
Large B Cell

The breast may be the site of primary lymphoma or be invaded secondarily by lymphoma from another organ [1]. Unilateral localisation is the most frequent.. The majority of lymphomas are of B-cell type. The most frequent type is represented by diffuse large B-cell lymphoma, which present, when primary, a peculiar type of relapse in the central nervous system. Only limited surgery should be done in all type of lymphomas. The treatment is based on chemotherapy and immunotherapy,The prognosis is generally pejorative with.We report a case of primary breast non-Hodgkins malignant lymphoma in a 70-year-old patientAt the same time, a review of the literature is undertaken evoking the epidemiological, clinical, histological and therapeutic aspects of this neoplasm.

scholarly journals Use of Liquid-based Cytology and Cell Block Combined Technique for an Accurate Diagnosis of Oral Diffuse Large B Cell Lymphoma: A Case Report

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 823
Author(s):  
Aya Yoshino ◽  
Shintaro Ishida ◽  
Shinsuke Nakamura ◽  
Ryosuke Kita ◽  
Mika Seto ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Significant Risk ◽  
B Cell Lymphoma ◽  
Accurate Diagnosis ◽  
Cell Block ◽  
Oral Diseases ◽  
Large B Cell Lymphoma ◽  
Liquid Based Cytology ◽  
Large B Cell

Primary oral diffuse large B cell lymphoma (DLBCL) is rare and the differential diagnosis is difficult due to its low incidence and nonspecific symptoms, which resemble those of common oral diseases in the initial clinical setting. We aimed to discuss the value of making an accurate diagnosis using liquid-based cytology (LBC) and cell block (CB) for not only the morphological interpretation but also cytohistological assessment of oral DLBCL. LBC and CBs made from oral brushing materials were prepared on the first medical examination and a morphological analysis and immunohistochemical analysis of specific biomarkers were performed. The analysis of LBC preparations showed the presence of large-size lymphocytes with large irregular nuclei and prominent nucleoli, suggesting the existence of large B-cell lymphoma. A more detailed histological subclassification of the CB specimen was performed, which was classified as the activated B-cell (ABC) phenotype of DLBCL, by confirming the immunohistochemical expression of CD10−/ B-cell lymphoma 6 (BCL6)+/ multiple myeloma oncogene 1(MUM1)+, which is a significant risk factor in DLBCL. Our findings suggest that the combination of LBC and CB is a useful and informative tool for making an accurate molecular diagnosis of oral DLBCL in cases in which lymphomas are clinically suspected.

Diagnostic Value of 18F-PET/CT in Patients with Primary Lymphoma and the Prognostic Value of Maximum Standardized Uptake Value (SUVmax) in Diffuse Large B-Cell Lymphoma (DLBCL)

2021 ◽  
Author(s):  
Lin Zhu ◽  
Kai Nie ◽  
Yinan Chen ◽  
Jing Liu ◽  
Yongxing Xiao ◽  
...  
Keyword(s):  
B Cell ◽  
Prognostic Value ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Diagnostic Value ◽  
Primary Lymphoma ◽  
Ki 67 ◽  
Large B Cell Lymphoma ◽  
Pet Ct ◽  
Large B Cell

Abstract Background The diagnostic accuracy of 18F-PET/CT was assessed in patients with primary lymphoma and the clinical application value of SUVmax was determined. Results The diagnostic accuracy of a total of 97 patients with initial 18F-PET/CT scans between January 2015 and February 2020 were assessed, and the SUVmax was compared according to the different pathological subtypes. The relationship between SUVmax and immunophenotype, clinical characteristics, and genetic types were estimated. According to the pathological results, 10 cases were misdiagnosed by PET/CT, and the accuracy was about 90%. Statistical analysis did not reveal a significant difference between Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) (p = 0.9071). Among NHL, the average SUVmax was statistically different between diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) (p = 0.0004), FL and natural killer/T-cell lymphoma (p = 0.0078), FL and peripheral T-cell lymphoma (PTCL) (p = 0.0117), DLBCL and mantle cell lymphoma (MCL) (p = 0.0294). In patients with DLBCL, SUVmax was correlated with the expression level of proliferation index Ki-67 (r = 0.33, p = 0.018), while average SUVmax shows no difference between various immunophenotype expression levels, ages, gender, skeletal invasion situations, clinical grade stages, international prognostic index (IPI) score, and different gene types (germinal center B cell-like (GCB) and non-GCB). Conclusions Although 18F-PET/CT had a marked diagnostic value in patients with primary lymphoma, some misdiagnosis was probable. The SUVmax is valuable in the differential diagnosis of different pathological types of NHL. Simultaneously, the SUVmax of patients with DLBCL correlated with Ki-67 might reflect the tumor invasiveness, thereby revealing a prognostic value.

scholarly journals Aberrant Overexpression and Regulatory Mechanism of Mir-21 in Diffuse Large B Cell Lymphoma

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 5171-5171 ◽  
Author(s):  
Rong Fu ◽  
Chunhong Li ◽  
Zonghong Shao
Keyword(s):  
B Cell ◽  
Conflicts Of Interest ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Pten Expression ◽  
Primary Lymphoma ◽  
Phosphatase And Tensin Homolog ◽  
Tensin Homolog ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract MicroRNAs (miRNAs) are critically responsible for lymphomagenesis. We found that miR-21 expression was significantly higher in diffuse large B cell lymphoma (DLBCL) line and paraffin-embedded tissue of primary lymphoma (n = 26) than that in normal lymph nodes (n = 10). To determine the functions of miR-21 in lymphomagenesis, we examined phosphatase and tensin homolog (PTEN) expression using immunohistochemical SP method in specimens of primary DLBCL. MiR-21 expression is negatively correlated with PTEN expression, but positively correlated with LDH. MiR-21 expression was significantly higher in stage III / IV patients than in stage I/II patients. Moreover, we examined the effects of antisense oligonucleotide (ASO) targeting miR-21 (ASO-21) in the DLCBL line overexpressing this miRNA. Electroporation was used to transfect ASO-21 into the cells, which showed slight endogenous miR-21 expression. Downregulating miR-21 expression resulted in increased incidence of apoptosis and PTEN upregulation. These results provide relevant new insight into the pathogenesis of DLBCL and suggest that targeting miR-21 may represent a useful approach for DLBCL treatment, and that high levels of miR-21 may be associated with increased poor prognosis for DLBCL patients. Disclosures No relevant conflicts of interest to declare.

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