Intralesional Steroid Treatment of Aggressive Central Giant Cell Granuloma of the Mandible

2019 ◽  
Author(s):  
Mohammed H. Al-Bodbaij
Keyword(s):  
Giant Cell ◽  
Treatment Modalities ◽  
Giant Cell Granuloma ◽  
Recurrence Rates ◽  
Current Case ◽  
Central Giant Cell Granuloma ◽  
Neoplastic Lesion ◽  
Intralesional Steroid ◽  
Intralesional Injections ◽  
Children And Young Adults

Central giant cell granuloma (CGCG) is a non-neoplastic lesion that affects children and young adults. Various treatment modalities have been suggested for CGCG. The most commonly applied is surgery with possible variable recurrence rates. Other treatment modalities such as calcitonin and intralesional steroid have been used with good results. In the current case report, a 14-year old boy presented with an aggressive CGCG of the mandible that had been treated with six weekly intralesional injections of steroids that provided very good results.

Management of recurrent central giant cell granuloma of mandible using intralesional corticosteroid with long-term follow-up

2020 ◽  
Vol 13 (9) ◽  
pp. e237200
Author(s):  
Kumar Nilesh ◽  
Anuj Dadhich ◽  
Rahul Patil
Keyword(s):  
Giant Cell ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Ablative Surgery ◽  
Long Term Follow Up ◽  
Intralesional Injections

Central giant cell granuloma (CGCG) is an expansile osteolytic lesion of the jawbone. Conventional treatment of CGCG is surgical and vary from simple curettage to more aggressive resection of the jaw. However, surgical management is associated with drawbacks including requirement of hospitalisation and general anaesthesia, damage to vital anatomic structures and continuity defect of the mandible requiring reconstruction surgery. Use of intralesional injections of corticosteroid for the management of CGCG have been inconsistently used as an alternative non-surgical method of management of CGCG with varying success. While the use of such conservative modality over ablative surgery can significantly reduce postoperative morbidity, follow-up of such cases for a long period is important to study the possible recurrence. This paper reports successful treatment of a recurrent CGCG of posterior mandible by intralesional administration of triamcinolone acetonide in a 27-year old female patient, with long-term follow-up of 10 years.

scholarly journals Central Giant Cell Granuloma of the Jaws: A Short Series and Review of Literature

2011 ◽  
Vol 2 (3) ◽  
pp. 217-223 ◽  
Author(s):  
Sugandha Mohan ◽  
Virender Singh ◽  
SK Mathur ◽  
Parveen Rana Kundu
Keyword(s):  
Giant Cell ◽  
Minimal Risk ◽  
Histopathologic Examination ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Radiologic Evaluation ◽  
Radiologic Findings ◽  
Precise Diagnosis ◽  
Children And Young Adults ◽  
Anterior Mandible

ABSTRACT Introduction Central giant cell granuloma (CGCG) accounts for less than 7% of all lesions of the jaw. It occurs more commonly in the anterior mandible compared to the maxilla. Females have 2 to 3 times higher incidence. Children and young adults are affected the most. Materials and methods The present series reviews 10 cases of CGCG suspected on clinical and radiologic basis and confirmed by histopathologic examination. Results The age of 10 cases ranged from 7 to 32 years (mean age 19.8); there were six females and four males; six had lesion in the lower jaw and the remaining four in the upper jaw. After radiologic evaluation, the treatment involved surgical curettage which was subjected to histopathologic examination and diagnosed as CGCG. Conclusions CGCG is diagnosed by a combination of clinical and radiologic findings and confirmed by histopathology. The condition needs to be distinguished from other giant cell containing lesions. The early and precise diagnosis of CGCG allows conservative management with minimal risk to the adjacent tooth or bone.

scholarly journals Central giant cell granuloma in the mandibula: clinical, radiological and histopathological study in 2 clinical cases

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Gheorghe Tibirna ◽  
◽  
Silvia Railean ◽  
Egor Porosencov ◽  
Tatiana Porosencova ◽  
...  
Keyword(s):  
General Population ◽  
Giant Cell ◽  
Biological Behavior ◽  
Unknown Etiology ◽  
Histopathological Study ◽  
Giant Cell Granuloma ◽  
Local Inflammation ◽  
Central Giant Cell Granuloma ◽  
Neoplastic Lesion ◽  
Proliferative Lesion

Central giant cell granuloma (CGCG) is a benign and proliferative lesion of the jaw, with an unknown etiology. It is widely considered to be a neoplastic lesion. The current etiology of GCGC is still unclear, although local inflammation, bleeding, and trauma have been suggested. The biological behavior of CGCG of the jaw varies from resting to aggressive with destructive expansion. The incidence in the general population is very low, and patients are generally under 30 years of age females. In this study, we report two cases of GCGC in 8-year-old and 13 year old girls treated surgically.

scholarly journals Treatment of Cherubism with Salmon Calcitonin: A Case Report

2011 ◽  
Vol 05 (04) ◽  
pp. 486-491 ◽  
Author(s):  
Osman A Etoz ◽  
Dogan Dolanmaz ◽  
Omer Gunhan
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Autosomal Dominant ◽  
Present Report ◽  
Nasal Administration ◽  
Nasal Passage ◽  
Giant Cell Granuloma ◽  
Steroid Injections ◽  
Central Giant Cell Granuloma ◽  
Intralesional Steroid

ABSTRACTCherubism is a familial disease of the jaws which is inherited via autosomal dominant manner. Typical features of cherubism include a painless bilateral, symmetrical enlargement of the jaws, misalignment of teeth, and intra-osseous central giant cell granuloma-like lesions, which are usually evident in early childhood. Treatment of cherubism consists of local curettage of the lesions, jaw contouring, intralesional steroid injections, and systemic calcitonin administration as well. Calcitonin therapy for central giant cell granuloma of the jaws is well documented, and favorable results have been achieved. However, fewer reports have been presented in regard to calcitonin administration for cherubism. In the present report, a 14-year-old boy with cherubism who had intra-osseous cherubic lesions in his mandible was treated with an administration of 200 IU systemic calcitonin every other day via his nasal passage for duration of more than two years. After 30 months of calcitonin therapy, the lesions in the mandible were significantly regressed, and calcitonin application was ceased. Despite some drawbacks, such as unpredictable efficient absorption and patient tolerability, nasal administration is the easiest way to use calcitonin therapy on children. In this report, every-other-day applications of calcitonin increased patient tolerability and might be considered as an effective treatment for mild cherubic lesions. (Eur J Dent 2011;5:486-491)

scholarly journals Fine Needle Aspiration Cytology and Intralesional Steroid Injection in a Central Giant Cell Granuloma Affecting the Gingiva: A New Clinical Approach

2013 ◽  
Vol 24 (4) ◽  
pp. 420-427 ◽  
Author(s):  
Felipe Paiva Fonseca ◽  
Ana Carolina Prado Ribeiro ◽  
Alan Roger dos Santos-Silva ◽  
Pablo Agustin Vargas ◽  
Marcio Ajudarte Lopes
Keyword(s):  
Giant Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Giant Cell Granuloma ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Central Giant Cell Granuloma ◽  
Intralesional Injections ◽  
Needle Aspiration Cytology

Central giant cell granuloma (CGCG) is a benign jaw lesion predominantly found in the mandible of young female patients with a variable clinical behavior. Although surgical management is regarded as the main treatment modality for this lesion, the use of intralesional injections of steroids has been recently advocated for its treatment. In addition to this conservative management, the use of fine needle aspiration cytology (FNAC) for diagnosing CGCGs has been proven a safe and efficient approach, especially useful in cases with lesions located in esthetic regions. Herein, it is described a case of CGCG extending to the overlying gingiva of a 15-year-old male patient diagnosed by FNAC and subsequently treated with intralesional injections of a solution of triamcinolone acetonide and ethanolamine oleate that led to an important clinical remission, allowing a more conservative surgical procedure for preservation of gingival esthetics. Therefore, both procedures can be considered as management options for CGCG of the jaws.

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