scholarly journals The Structural Basis of Functional Improvement in Response to Human Umbilical Cord Blood Stem Cell Transplantation in Hearts with Postinfarct LV Remodeling

2015 ◽  
Vol 24 (6) ◽  
pp. 971-983 ◽  
Author(s):  
Yong Chen ◽  
Lei Ye ◽  
Jia Zhong ◽  
Xin Li ◽  
Chen Yan ◽  
...  
2021 ◽  
Vol 8 ◽  
Author(s):  
Yangyan Wang ◽  
Yuanyuan Dai ◽  
Huaiwei Lu ◽  
Wenjiao Chang ◽  
Fan Ma ◽  
...  

We report a case of hospital-acquired Legionella pneumonia that was detected by metagenomic next-generation sequencing (mNGS) of blood from a 7-year-old girl after umbilical cord blood stem cell transplantation (UCBT) with myelodysplastic syndrome. UCBT is traditionally associated with an increased risk of infection, particularly during the first 3 months after transplantation. Controlling interstitial pneumonia and severe infection is the key to reducing patient mortality from infection. Legionella pneumophila can cause a mild cough to rapidly fatal pneumonia. After mNGS confirmed that the pathogen was L. pneumophila, azithromycin, cefoperazone sulbactam, and posaconazole were used for treatment, and the patient's temperature decreased and remained normal. The details of this case highlight the benefits of the timely use of metagenomic NGS to identify pathogens for the survival of immunocompromised patients.


2009 ◽  
Vol 234 (3) ◽  
pp. 342-353 ◽  
Author(s):  
Hong Lin ◽  
Elisa De Stanchina ◽  
Xi Kathy Zhou ◽  
YuHong She ◽  
Danthanh Hoang ◽  
...  

2010 ◽  
Vol 84 (3) ◽  
pp. 274-275 ◽  
Author(s):  
Gergely Kriván ◽  
Melinda Erdős ◽  
Krisztián Kállay ◽  
Gábor Benyó ◽  
Ágnes Tóth ◽  
...  

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