scholarly journals Tissue Engineering - Collagen Matrix Based Flaps - a Simple Construct. Experimental and Theoretical Aspects

2019 ◽  
Vol 70 (10) ◽  
pp. 3694-3699
Keyword(s):  
Tissue Engineering ◽  
Free Flap ◽  
Collagen Matrix ◽  
Spontaneous Breaking ◽  
Network Development ◽  
Thickness Skin ◽  
Vascular Connections ◽  
Keywords Tissue Engineering ◽  
Arteriovenous Loop ◽  
Breaking Symmetry

In our study we demonstrate the possibility to create a free flap using only a collagen matrix and a vascular pedicle. The processes of cell migration and differentiation, endogenous collagen synthesis, vascular network development, all rely on the arteriovenous loop introduced in the scaffold with no participation of surrounding vascularity. The flap has the capability to revascularize a full thickness skin graft, and also to establish vascular connections with adjacent vascular territories. Also, a fractal mathematical model was built based on spontaneous breaking symmetry to explain the behaviors of biostructures mentioned above. Keywords: tissue engineering, collagen matrix, neovascularisation, free flap

scholarly journals Tissue Engineering - Collagen Matrix Based Flaps - a Simple Construct. Experimental and Theoretical Aspects

2019 ◽  
Vol 70 (10) ◽  
pp. 3694-3699
Author(s):  
Sidonia Susanu ◽  
Andreea Moraru ◽  
Dan Costin ◽  
Cristina Marcela Rusu ◽  
Maricel Agop ◽  
...  
Keyword(s):  
Collagen Synthesis ◽  
Collagen Matrix ◽  
Spontaneous Breaking ◽  
Vascular Pedicle ◽  
Network Development ◽  
Full Thickness Skin Graft ◽  
Thickness Skin ◽  
Vascular Connections ◽  
Arteriovenous Loop ◽  
Breaking Symmetry

In our study we demonstrate the possibility to create a free flap using only a collagen matrix and a vascular pedicle. The processes of cell migration and differentiation, endogenous collagen synthesis, vascular network development, all rely on the arteriovenous loop introduced in the scaffold with no participation of surrounding vascularity. The flap has the capability to revascularize a full thickness skin graft, and also to establish vascular connections with adjacent vascular territories. Also, a fractal mathematical model was built based on spontaneous breaking symmetry to explain the behaviors of biostructures mentioned above.

scholarly journals Free Flap Transfer with Arteriovenous Loop Establishment for Upper Limb Salvage in a Crush Injury

2018 ◽  
Vol 6 (11) ◽  
pp. e1913 ◽  
Author(s):  
Mohammad S. Radwan ◽  
Ammar Z. Barakat ◽  
Mohammad M. Jaber ◽  
Ashraf A. Mashal
Keyword(s):  
Limb Salvage ◽  
Upper Limb ◽  
Free Flap ◽  
Crush Injury ◽  
Flap Transfer ◽  
Free Flap Transfer ◽  
Arteriovenous Loop

Tissue Engineering of Lymphatic Vasculature in the Arteriovenous Loop Model of the Rat

2020 ◽  
Author(s):  
Jan W. Robering ◽  
Majida Al-Abboodi ◽  
Adriana Titzmann ◽  
Inge Horn ◽  
Justus P. Beier ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Loop Model ◽  
Lymphatic Vasculature ◽  
Arteriovenous Loop

Suprafascial Harvest of the Radial Forearm Free Flap Decreases the Risk of Postoperative Tendon Exposure

2017 ◽  
Vol 126 (3) ◽  
pp. 224-228 ◽  
Author(s):  
David C. Shonka ◽  
Nikita V. Kohli ◽  
Benjamin M. Milam ◽  
Mark J. Jameson
Keyword(s):  
Free Flap ◽  
Donor Site ◽  
Retrospective Chart Review ◽  
Split Thickness Skin Graft ◽  
Radial Forearm Free Flap ◽  
Tourniquet Time ◽  
Exact Test ◽  
Harvest Technique ◽  
Thickness Skin ◽  
Radial Forearm

Objective: To determine if suprafascial harvest of the radial forearm free flap improves postoperative donor site outcomes compared to subfascial harvest. Methods: Retrospective chart review. Results: Forty-six patients underwent reconstruction of a head and neck defect with a radial forearm free flap (RFFF). Subfascial harvest of the RFFF was performed in 25 (53%) patients and suprafascial harvest performed in 22 (47%) patients. All donor sites were covered with a split thickness skin graft and a bolster that remained in place for 6 days. Postoperative tendon exposure at the donor site occurred in 5 (20%) of the patients in the subfascial group and in 0 (0%) of the patients in the suprafascial group ( P = .05; Fisher’s exact test). Average tourniquet time was 117 minutes in the subfascial group and 102 minutes in the suprafascial group. Hematoma formation occurred at the donor site in 2 (8%) and 1 (5%) patients in the subfascial and suprafascial groups, respectively. There were no complete or partial flap losses in either group. Conclusions: Suprafascial harvest of the RFFF decreases the risk of postoperative tendon exposure. The suprafascial harvest technique does not increase harvest time or donor site complications, nor does it negatively impact flap vascularity.

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