scholarly journals The Use of Neoprene in Experimental Pancreatitis

2019 ◽  
Vol 70 (2) ◽  
pp. 676-678
Author(s):  
Alexandru Grigorovici ◽  
cristian Velicescu ◽  
Delia Hinganu ◽  
Alina Calin ◽  
Marius Valeriu Hinganu ◽  
...  
Keyword(s):  
Experimental Study ◽  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Pancreatic Duct ◽  
Genetically Modified ◽  
Pancreatic Tissue ◽  
Experimental Pancreatitis ◽  
Pancreatic Ducts ◽  
Genetically Modified Animals

The concept of chronic pancreatitis has been stated in our country much later than acute pancreatitis. This manuscript proposes a synthesis of the etiopathogenic, diagnostic and therapeutic data in chronic pancreatitis based on actual information correlated with the results of our experimental study. The experiment was conducted on 18 animals, in which was performed the intraduodenal ligation of the pancreatic duct apertures and the obstruction of the pancreatic ducts with intraparenchymatous, intraoperative neoprene injections. We investigated the lesions by using intraoperative pancreatic tissue collected after injections. The results encourage us to continue the research and to choose genetically modified animals because are closer to the human one.

scholarly journals CT Image Changes of Severe Acute Pancreatitis Based on Smart Electronic Medical Augmented Reality in Nursing Practice

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Defen Zhang ◽  
Shifang Mao ◽  
Siyou Lan ◽  
Chengli Zhou ◽  
Xiaoyan Liu
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Juice ◽  
Nursing Practice ◽  
Imaging System ◽  
Pancreatic Tissue ◽  
Ct Imaging ◽  
Pancreatic Ducts ◽  
Ct Image ◽  
Internal Drainage

Severe acute pancreatitis (SAP) is traditionally treated with chemical analysis. Faced with the increasing maturity of CT imaging technology, it is necessary to use more advantageous CT imaging to treat SAP. In this article, 72 SAP patients admitted to the Affiliated Hospital of Southwest Medical University were selected for study, of which 62 were severely ill, 8 were exacerbated, and 2 changed from severe to mild. This article combines the patient’s case records and related CT images during treatment from the perspective of nursing and conducts nursing research on the application of CT image changes in severe acute pancreatitis in nursing practice. CT image processing uses CT imaging system workstation (DICOM). The results of the study showed that, in the care of patients, 21 cases had recurrence after internal drainage, and the cure rate was 91.1%. Internal drainage is an effective way to treat SAP. The higher the incidence of pancreatitis, the more likely it is to relapse after SAP internal drainage, which may be related to repeated episodes of pancreatitis and repeated inflammation of the pancreas and pancreatic duct damage. 4 of the relapsed cases in this article are postchronic pancreatitis SAP, and the relapsed cases account for 50% of the chronic pancreatic cases. This may be due to chronic fibrosis of the branched and main pancreatic ducts, continuous abnormal pancreatic juice drainage. Therefore, it is necessary to further explore the prognosis of different causes of SAP. In terms of complication care, the overall complication rate was 16.6%. One patient died of postoperative hemorrhage. Analysis of the causes of cyst recurrence and complications may be closely related to the mechanism of the occurrence and development of SAP. The initiating factor of SAP is that the pancreatic tissue is damaged due to inflammation, trauma, or microcirculation disorder, and then the pancreatic juice leaks out of the pancreas, wrapping the pancreatic juice; it takes a certain time for the capsule of fibrous knot tissue to form and strengthen.

Combined minimaly invasive surgery of pancreaticolithiasis in combination with congenital stricture of the terminal sections of the pancreatic ducts

2017 ◽  
Vol 8 (5) ◽  
pp. 96-102
Author(s):  
Mikhail P. Korolev ◽  
Leonid E. Fedotov ◽  
Ruben G. Avanesyan ◽  
Elena A. Mikhailova ◽  
Georgiy M. Lepekhin ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Magnetic Resonance ◽  
Minimally Invasive ◽  
Pancreatic Duct ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Pancreatic Ducts ◽  
Invasive Treatment ◽  
Percutaneous Access ◽  
Joint Application

Chronic pancreatitis with pancreatic hypertension is extremely rare in childhood. Chronic pancreatitis in this age is usually always associated with a сongenital defect of the pancreatic duct system. The article describes the case of long-term clinical observation and minimally invasive treatment of chronic calculous pancreatitis, first diagnosed in a girl at the age of 16 years. Despite the fact that clinical manifestations were observed from the age of 3 years, the correct diagnosis could be made only at the age of 16, by joint application of ultrasound, Magnetic Resonance Imaging (MRI) and Magnetic Resonance Cholangiopancreatography (MRCP). The cause of chronic pancreatitis were concrements and strictures of the main and additional pancreatic ducts that caused pancreatic hypertension. Attempt of endoscopic retrograde lithoextraction from the pancreatic ducts was impossible because of the presence of severe stricture. Therefore, it was decided to apply a combined approach using percutaneous access under ultrasound navigation. The patient underwent series of minimally invasive combined procedures including the lithoextraction, balloon dilatation and transcutaneous drainage of the pancreatic ducts with the endoscopic and percutaneous access with ultrasound and radiologic control. For the prevention of restenosis, the antegrade stenting of the main pancreatic duct with self-expanding coated nitinol stent was used with further removal of the stent. Due to the treatment, there was no pancreatitis within 5 years after stent removal.

scholarly journals Motion - Pancreatic Endoscopy is Useful for the Pain of Chronic Pancreatitis: Arguments for the Motion

2003 ◽  
Vol 17 (1) ◽  
pp. 57-59
Author(s):  
Stanley M Branch
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Duct ◽  
Endoscopic Therapy ◽  
Clinical Problem ◽  
Pancreatic Pseudocysts ◽  
Pancreatic Ducts ◽  
Success Rates ◽  
Long Term Follow Up

Pain is the dominant clinical problem in patients with chronic pancreatitis. It can be due to pseudocysts, as well as strictures and stones in the pancreatic ducts. Most experts agree that obstruction could cause increased pressure within the main pancreatic duct or its branches, resulting in pain. Endoscopic therapy aims to alleviate pain by reducing the pressure within the ductal system and draining pseudocysts. Approaches vary according to the specific nature of the problem, and include transgastric, transduodenal and transpapillary stenting and drainage. Additional techniques for the removal of stones from the pancreatic duct include extracorporeal shockwave lithotripsy. Success rates for stone extraction and stenting of strictures are high in specialized centres that employ experienced endoscopists, but pain often recurs during long term follow-up. Complications include pancreatitis, bleeding, infection and perforation. In the case of pancreatic pseudocysts, percutaneous or even surgical drainage should be considered if septae or large amounts of debris are present within the lesion. This article describes the techniques, indications and results of endoscopic therapy of pancreatic lesions.

scholarly journals Validation of a commercial 1,2-o-dilauryl-rac-glycero glutaric acid-(6’-methylresorufin) ester lipase assay for diagnosis of canine pancreatitis

2018 ◽  
Vol 5 (1) ◽  
pp. e000270 ◽  
Author(s):  
Emily L Goodband ◽  
Gonçalo Serrano ◽  
Fernando Constantino-Casas ◽  
Joy Archer ◽  
Penny J Watson ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Sensitivity And Specificity ◽  
Glutaric Acid ◽  
Reference Interval ◽  
Pancreatic Tissue ◽  
Serum Samples ◽  
Technical Validation ◽  
Two Parameters ◽  
Acute And Chronic Pancreatitis

The objectives of this study were fourfold: technical validation of a commercial canine 1,2-o-dilauryl-rac-glycero glutaric acid-(6’-methylresorufin) ester (DGGR) lipase assay, to calculate a reference interval for DGGR lipase by the indirect a posteriori method, to establish biological validity of the assay, and to assess agreement between DGGR lipase and specific canine pancreatic lipase (Spec cPL) assays. Dogs with histologically confirmed acute pancreatitis (n=3), chronic pancreatitis (n=8) and normal pancreatic tissue (n=7) with stored (−80°C) serum samples were identified. Relevant controls were selected. Precision, reproducibility and linearity of DGGR lipase, and the effect of sample haemolysis and freezing, were assessed. Sensitivity and specificity of DGGR lipase and Spec cPL were determined. Agreement between these two parameters was calculated using Cohen’s kappa coefficient (κ). The DGGR lipase assay demonstrated excellent precision, reproducibility and linearity. Sample haemolysis and storage at −80°C for 12 months did not influence the assay. DGGR lipase (>245IU/l) and Spec cPL (>400µg/l) both showed poor sensitivity but excellent specificity for acute pancreatitis, and poor to moderate sensitivity but excellent specificity for chronic pancreatitis. Substantial agreement (κ=0.679) was found between DGGR lipase and Spec cPL. The validated DGGR lipase assay had similar sensitivity and specificity for the diagnosis of acute and chronic pancreatitis to Spec cPL. DGGR lipase is a reliable alternative to Spec cPL for the diagnosis of pancreatitis.

scholarly journals Changes in the ducts of the pancreas with pancreatic necrosis

2019 ◽  
Vol 23 (3) ◽  
pp. 349-353
Author(s):  
G.Ya. Kostyuk ◽  
O.G. Kostyuk ◽  
M.V. Burkov ◽  
I.A. Golubovsky ◽  
M.P. Bulko ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Duct ◽  
Histological Examination ◽  
Pancreatic Secretion ◽  
Pancreatic Necrosis ◽  
Experimental Studies ◽  
Pancreatic Ducts ◽  
Severe Pancreatitis ◽  
Hematoxylin And Eosin ◽  
Blood Elements

The article presents data on the development in the lumen of the pancreatic duct of condensed protein masses in people who died from the development of severe acute pancreatitis. 10 pancreas (areas of the head, body and tail, ductal system of the pancreas) of people who died of acute pancreatitis were subjected to histological examination. The material was fixed in 10% formalin solution, carried out in alcohols of increasing strength and enclosed in celloidin. The sections were stained with hematoxylin and eosin. A histological examination revealed that the condensed masses were represented by heterogeneous protein formations, cells of desquamated ductal epithelium, blood elements, fibrin threads. They completely filled the lumen of the pancreatic ducts and stopped the movement of pancreatic secretion. The data on the treatment of severe pancreatitis in experimental studies using the method of bougie and washing the pancreatic ducts with a novocaine-contrical mixture are presented. Two methods are proposed for restoring the permeability of the pancreatic duct in pancreatic necrosis in humans. Possible ways of the formation of fistulas and cysts are suggested, as a complication in the severe course of acute pancreatitis.

scholarly journals Ansa pancreatica: a rare cause of acute recurrent episode in chronic pancreatitis

2020 ◽  
pp. 20200044
Author(s):  
Hind Guerroum ◽  
Amal Rami ◽  
Mariam Kassimi ◽  
Jihane Habi ◽  
Rahmouni Imane ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Duct ◽  
Anatomic Variation ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Pancreatic Ducts ◽  
Predisposing Factor ◽  
Minor Papilla ◽  
Head Of The Pancreas ◽  
Ansa Pancreatica

Ansa pancreatica is a rare anatomic variation of pancreatic ducts. It is a predisposing factor of recurrent pancreatitis. In this case report, we describe a case of a 24-year-old male suffering from an ansa pancreatica with a non-patent major papilla, diagnosed on magnetic resonance cholangiopancreatography (MRCP).The ansa pancreatica was revealed by an episode of acute pancreatitis attacks in chronic pancreatitis. Endoscopic retrograde cholangiopancreatography (ERCP) confirmed important abrupt dilation in the main pancreatic duct with an ansa loop in the pancreatic duct in the head of the pancreas, and a sphincterotomy of the minor papilla was performed. The procedure was difficult and the placement of a long-term pancreatic stent during the ERCP was impossible, thus a surgical pancreatico-jejunostomy was proposed as a treatment of an ansa pancreatica with a non-patent major papilla.

scholarly journals Prospective observational study on pancreatic duct system diversity in different pancreatic diseases

2017 ◽  
Vol 4 (10) ◽  
pp. 3330
Author(s):  
Navjot Singh Brar ◽  
Rajbir Singh Bajwa
Keyword(s):  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Pancreatic Duct ◽  
Pancreatic Head ◽  
Lemon Juice ◽  
Imaging Modalities ◽  
Cystic Neoplasm ◽  
Pancreatic Diseases ◽  
Ductal System ◽  
Pancreatic Disorders

Background: Pancreatology and pancreatic surgery was developed on the basis of increase in knowledge of anatomy and physiology of the pancreas in the beginning of the 20th century. Although our knowledge of pancreatic head anatomy has increased, anatomical data characterizing the pancreatic ductal system remain limited. Furthermore, the relation of pancreatic ductal system anomalies and different pancreatic disorders remain to be evaluated.Methods: The present study was conducted in Department of Paediatric, Sri Guru Ram Das Institute of Medical Sciences and Research, Vallah, Sri Amritsar from August 2014 to November 2016. Total 50 subjects were included. Study was done with aim to study cases clinically and segregate cases with pancreatic disorder which need evaluation by special imaging modalities and surgical management, to compare the nature of information obtained from various modalities to study various corollaries of modern imaging study, to study whether the information from various imaging modalities are complimentary, competitive and to study pancreatic ductal structure in different pancreatic diseases.Results: In the present study, we have a total of 50 patients. Among them 25 (50%) suffer from chronic pancreatitis, 13 (26%) from acute pancreatitis, 6 (12%) from periampullary carcinoma, 3 (6%) from carcinoma head of the pancreas, 1 (2%) from pancreatic ascites following acute pancreatitis, 1 (2%) from annular pancreas and 1 (2%) from cystic neoplasm of pancreas. These patients were investigated by transabdominal USG, MDCT scan, ERCP and conventional and stimulated MRCP to study the pancreatic duct diversities in different pancreatic diseases and the advantage of lemon juice stimulated MRCP over conventional MRCP.Conclusions: Pancreatic disorders were most frequently seen in male patients. Age group between 31 to 50 years were mostly suffering from inflammatory disorders like acute and chronic pancreatitis. The frequency of malignant condition was increased after 50 years of age. Most common pancreatic disorder in our study was chronic pancreatitis. Trans-abdominal USG was found to be very useful initial investigation for the evaluation of pancreatic duct morphology. Best investigation for malignant pancreatic condition was MDCT following pancreatic protocol.

scholarly journals The Analgesic Effect of the Mitochondria-Targeted Antioxidant SkQ1 in Pancreatic Inflammation

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Maximilian Weniger ◽  
Leonard Reinelt ◽  
Jens Neumann ◽  
Lesca Holdt ◽  
Matthias Ilmer ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Analgesic Effect ◽  
Tissue Injury ◽  
Behavioral Observation ◽  
Pancreatic Tissue ◽  
Mechanical Sensitivity ◽  
Risks And Benefits ◽  
Reduction Of Pain ◽  
Acute And Chronic Pancreatitis

Background. Chronic pancreatitis is one of the main risk factors for pancreatic cancer. In acute and chronic pancreatitis, oxidative stress is thought to play a key role. In this respect, the recently described mitochondria-targeted antioxidant SkQ1 effectively scavenges reactive oxygen species at nanomolar concentrations. Therefore, we aimed to characterize the influence of SkQ1 on tissue injury and pain in acute and chronic pancreatitis.Methods. Both acute and chronic pancreatitis were induced in C57BL/6 mice by intraperitoneal cerulein injections and treatment with SkQ1 was carried out by peroral applications. Hyperalgesia was assessed by behavioral observation and measurement of abdominal mechanical sensitivity. Blood serum and pancreatic tissue were harvested for analysis of lipase and histology.Results. SkQ1 did not influence pain, serological, or histological parameters of tissue injury in acute pancreatitis. In chronic pancreatitis, a highly significant reduction of pain-related behavior (p<0.0001) was evident, but histological grading revealed increased tissue injury in SkQ1-treated animals (p=0.03).Conclusion. After SkQ1 treatment, tissue injury is not ameliorated in acute pancreatitis and increased in chronic pancreatitis. However, we show an analgesic effect in chronic pancreatitis. Further studies will need to elucidate the risks and benefits of mitochondria-targeted antioxidants as an analgesic.

scholarly journals Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat

1996 ◽  
Vol 5 (3) ◽  
pp. 202-205
Author(s):  
P. Jönsson ◽  
K. Ohlsson
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Duct ◽  
Experimental Pancreatitis ◽  
Peritoneal Exudate ◽  
Circulatory Shock ◽  
Experimental Acute Pancreatitis ◽  
Indirect Measurements ◽  
Necrotic Pancreatitis

Kallikrein/Kininogn activation is an important pathophysiological event in acute pancreatitis, leading to microcirculatory changes within the gland. Hitherto, only indirect measurements of pancreatic bradykinin formation have been performed, monitoring the peptide in the circulation and in the peritoneal exudate. In the present study, intra-pancreatic bradykinin release was assessed using microdialysis during experimental acute pancreatitis in rat. In mild, oedematous pancreatitis, induced by caerulein hyperstimulation, the levels of bradykinin within the gland were not elevated compared with those of control rats. However, in necrotic pancreatitis, induced by retrograde injection of taurocholate into the pancreatic duct, significantly elevated levels of intraglandular bradykinin were seen. Several rats in this group died whilst in a state of circulatory shock.

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