Verapamil HCl

2018 ◽  
pp. 868-871
Keyword(s):  
Verapamil Hcl

Microvascular oxygen delivery and consumption following treatment with verapamil

2005 ◽  
Vol 288 (4) ◽  
pp. H1515-H1520 ◽  
Author(s):  
Nanae Hangai-Hoger ◽  
Amy G. Tsai ◽  
Barbara Friesenecker ◽  
Pedro Cabrales ◽  
Marcos Intaglietta
Keyword(s):  
Oxygen Consumption ◽  
Vessel Wall ◽  
Muscle Relaxation ◽  
Capillary Density ◽  
Smooth Muscle Relaxation ◽  
Oxygen Release ◽  
Total Oxygen ◽  
Verapamil Hcl ◽  
Window Chamber ◽  
Vascular Smooth Muscle Relaxation

The microvascular distribution of oxygen was studied in the arterioles and venules of the awake hamster window chamber preparation to determine the contribution of vascular smooth muscle relaxation to oxygen consumption of the microvascular wall during verapamil-induced vasodilatation. Verapamil HCl delivered in a 0.1 mg/kg bolus injection followed by a continuous infusion of 0.01 mg·kg−1·min−1 caused significant arteriolar dilatation, increased microvascular flow and functional capillary density, and decreased arteriolar vessel wall transmural Po2 difference. Verapamil caused tissue Po2 to increase from 25.5 ± 4.1 mmHg under control condition to 32.0 ± 3.7 mmHg during verapamil treatment. Total oxygen released by the microcirculation to the tissue remained the same as at baseline. Maintenance of the same level of oxygen release to the tissue, increased tissue Po2, and decreased wall oxygen concentration gradient are compatible if vasodilatation significantly lowers vessel wall oxygen consumption, which in this model appears to constitute an important oxygen-consuming compartment. These findings show that treatment with verapamil, which increases oxygen supply through vasodilatation, may further improve tissue oxygenation by lowering oxygen consumption of the microcirculation.

scholarly journals Evaluation of Drug Release from Carboxymethyl Starch-Xanthan Gum-HPMC Matrix

2021 ◽  
Vol 11 (5) ◽  
pp. 27-32
Author(s):  
Amit Kumar Verma ◽  
Arun Kumar ◽  
Subbiah Ramasamy ◽  
Ajit Kumar Yadav ◽  
Rohit Kumar Bijauliya
Keyword(s):  
Drug Release ◽  
Xanthan Gum ◽  
Corn Starch ◽  
Methyl Cellulose ◽  
Oral Drug ◽  
Research Activity ◽  
Verapamil Hydrochloride ◽  
Carboxymethyl Starch ◽  
Verapamil Hcl ◽  
Regulatory Acceptance

The use of hydrophilic polymers from natural origin. Especially the polysaccharides have been the focus of current research activity in the design of matrix device due to their non toxic, biocompatible, biodegradable nature and broad regulatory acceptance. A large number of polysaccharides such as Carboxymethyl starch, Xanthan gum, Hydroxy propyl methyl cellulose (HPMC), Sodium Alginate etc, have been used as hydrophilic matrices to investigate release behavior of drug. In order to enrich the resources, there is a quest for new polysaccharide owing to their diverse chemical composition and functional groups are amenable to chemical modification and thus tailor made polymeric matrices are obtained which which can be used to modulate oral drug release. The objective of the study is to characterize Verapamil hydrochloride loaded matrix dosage form using hydroxy propyl methyl cellulose (HPMC), xanthan gum, corn starch as rate retarding polymer. Dosage forms were prepared using different polymers along with drug Verapamil hydrochloride. Carboxymethylation was performed. Drug release was evaluated in simulated gastric media. Addition of xanthan gum significantly retarded the burse release of drug. The retardation of drug release was found to be dependent upon the concentration. The formulation composed of HPMC K4M and CS (ARI-ARI3) followed super case transport is swelling controlled, purely relaxation controlled drug delivery. Keywords: Verapamil HCl, Natural gums, xanthan gum, HPMC, sustained release

scholarly journals PENGARUH MATRIKS PEKTIN DAN HPMC K15M TERHADAP DAYA MENGAPUNG DAN MENGEMBANG SERTA DISOLUSI PADA TABLET FLOATING VERAPAMIL HCl DENGAN METODE FACTORIAL DESIGN

2020 ◽  
Vol 9 (1) ◽  
pp. 27-35
Author(s):  
Valentina Ayuk Armadani ◽  
Siti Aisiyah ◽  
Ilham Kuncahyo
Keyword(s):  
Angina Pectoris ◽  
Factorial Design ◽  
Software Design ◽  
Lag Time ◽  
Verapamil Hcl

Verapamil HCl merupakan penghambat kanal Ca2+ untuk terapi hipertensi dan angina pectoris. Verapamil HCl memiliki bioavabilitas 10-20% dan waktu paruh 4 jam sehingga dapat dibuat sediaan gastroretentive untuk mempertahankan kadar terapi obat. Penelitian ini bertujuan mengetahui pengaruh matriks pektin dan HPMC K15M terhadap kemampuan mengapung, mengembang dan pelepasan obat pada tablet floating verapamil HCl.Penelitian ini menggunakan empat formula variasi konsentrasi matriks pektin dan HPMC K15M dengan metode kempa langsung kemudian dilakukan pengujian terhadap sifat fisik serbuk dan tablet. Pengaruh dan interaksi antara pektin dan HPMC K15M ditentukan dengan metode factorial design menggunakan software Design Expert.Matriks pektin dan HPMC K15M memberikan pengaruh terhadap kemampuan mengapung, mengembang dan pelepasan obat dari tablet floating verapamil HCl. HPMC K15M berpengaruh dominan terhadap floating lag time yang lebih cepat dan floating time yang lebih lama. Peningkatan HPMC K15M dan pektin menurunkan jumlah pelepasan di awal   dan   kecepatan   pelepasan   obat,   serta   meningkatkan   kemampuan   mengembang. Kombinasi pektin dan HPMC K15 M (1,5:1) mempunyai floating lag time cepat, floating time lama, dan kemampuan mengembang paling besar serta mengikuti orde nol.

Bioavailability enhancement of verapamil HCl via intranasal chitosan microspheres

2014 ◽  
Vol 51 ◽  
pp. 59-66 ◽  
Author(s):  
Mamdouh. Abdel Mouez ◽  
Noha M. Zaki ◽  
Samar Mansour ◽  
Ahmed S. Geneidi
Keyword(s):  
Bioavailability Enhancement ◽  
Chitosan Microspheres ◽  
Verapamil Hcl

Formulation Development and Evaluation of Fast Disintegrating Sustained Release Pellets Containing Verapamil Hydrochloride Tablets by Fluidized Bed Processor

2021 ◽  
pp. 261-266
Author(s):  
Jagruti J. Pansare ◽  
Rajendra K. Surawase
Keyword(s):  
Sustained Release ◽  
Fluidized Bed ◽  
Extended Period ◽  
Coating Film ◽  
Formulation Development ◽  
Eudragit Rs 30D ◽  
Fast Disintegrating Tablet ◽  
Model Drug ◽  
Verapamil Hcl ◽  
Tablet Hardness

This study aimed to developed novel fast disintegrating sustained release pellets containing tablet by using Fluidized Bed processor. Verapamil HCl used as a model drug for the formulation. Fluidized bed processor was used for coating of drug and polymer on the sugar spheres. To overcome the problem of swallowing for paediatric, geriatric, psychiatric, bedridden patients, uncooperative patients or for active patients who are busy and travelling and may not access to we aim to formulate the fast-disintegrating tablet. The superdisintigrant are commonly use like cross povidone, sodium starch glycolate which disintegrate tablet rapidly. It is assumed that, after the disintegration of tablets, pellets within tablets which are reside in GIT for several hours and gradually released a drug in controlled way. Eudragit RS 30D and ethyl cellulose were used as a sustained release polymer. Coating of spheres with sustained release film is achieved by bottom spray processor of FBP. Proper pellets coating film thickness, and concentration of polymers’, ensure obtaining desirable VH release profile for extended period of time, was defined. X composition of tablet with pellets were examined in order to obtained formulation, from which VH release would mostly appropriate pellets before compressing. Compression of pellets into tablet, being a modern technological process than enclosing them into hard gelatine capsule. The optimized batch evaluated by studied the effect of compression force, tablet hardness and friability and drug release from the pellets by sustained release manner.

Sign in / Sign up

Export Citation Format

Share Document