Review on Nanotechnology and its utilization in Pharmaceuticals

Nanotechnology is the study of tiny structures ranging in size from 0.1 to 100 nanometers. It includes biophysics, molecular biology, and bioengineering, as well as medical subspecialties such as cardiology, ophthalmology, endocrinology, oncology, and immunology. Pharmaceutical Nanotechnology combines the methods and ideas of nanoscience and nanomedicine with pharmacy to create novel medication delivery systems that transcend the limitations of traditional drug delivery systems. The purpose of this article is to provide an overview of nanotechnology and its uses in the pharmaceutical industry.

Review on Mucormycosis: It is a life Threatening infection

Mucormycosis, often known as black fungus, is a fungal infection caused by the mucormycetes fungi. Zygomycetes is a class of fungi. Mucormycetes, the fungus that cause mucormycosis, are found all throughout the world, especially in soil and in decaying organic waste like leaves, compost piles, and animal dung. It is not contagious and cannot be passed from one person to another. Mucormycosis (also known as zygomycosis) is a dangerous but uncommon fungal infection caused by a fungus known as mucormycetes. Molds can be found all over the place. Mucormycosis is a fungal infection that primarily affects persons who have health issues or who use medications that reduce the body's capacity to resist infections and illness. Infections are most typically acquired when mould spores are inhaled or, less commonly, when spores enter the body through a cut in the skin. It takes place after COVID-19. Home remedies, such as consuming probiotics, and foods that promote immunity, can help to minimise mucormycosis. The main purpose of this review Related to Mucormycosis is to diminish the growth of Mucormycosis by taking Ayurvedic Treatment.

Formulation and Evaluation of Orodispersble Tablet

The aim of present work is to formulate and develop tablets of promethazine HCL.by using various superdisintegrating agent by direct compression method. The main objective of the study is to increase rapid onset of action of promethazine HCL in the treatment of nausea and vomiting. The orodispersible tablet of promethazine hcl is were prepared by direct compression method. Using different concentration of Crospovidone, croscarmellose sodium Mannitol, lactose, maltose, mg. stearate. The tablet was evaluated by various parameters and result are found to be satisfactory.

Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride

The aim of the present study was to design and evaluate bilayer tablets of metformin hydrochloride as sustained release form for the treatment of Type-II diabetes mellitus. The basic aim of any Bi-layer tablet formulation is to separate physically or chemically incompatible ingredients and to produce repeat action or prolonged action of tablet. They are many drugs for treating type-II diabetes. Sulphonyl urea and biguanides are used commonly by a wide section of patients. Melt granulation process was used for the formulation of sustained comprising metformin layer and wet granulation of immediate comprising layer of glimepiride. The precompression studies like bulk density, tapped density, angle of repose, compressible index and post formulation studies includes weight variation, hardness, thickness, friability and dissolution study. The in-vitro release profile of Glimepiride was dissolved within 45 min, and Metformin Hydrochloride was able to release more than 12 hrs. They all the formulation was optimized formula due to its higher rate of dissolution and collate all other parameters with the official specifications.

Chemical Composition of Aegle marmelos: A Review

Aegle marmelos (Bilva) is being used in Ayurveda for the treatment of several inflammatory disorders. The plant is a member of a fixed dose combination of Dashamoola in Ayurveda. However, the usage of roots/root bark or stems is associated with sustainability concerns. Bael (Aegle marmelos (L.) Corr.) is an important medicinal plant of India. Leaves, fruits, stem and roots of A. marmelos have been used in ethno medicine to exploit its' medicinal properties including astringent, antidiarrheal antidysenteric, demulcent, antipyretic and anti-inflammatory activities. Compounds purified from bael have been proven to be biologically active against several major diseases including cancer, diabetes and cardiovascular diseases. Preclinical studies indicate the therapeutic potential of crude extracts of A. marmelos in the treatment of many microbial diseases, diabetes and gastric ulcer. This review covers the biological activities of some isolated chemical constituents of A. marmelos and preclinical studies on some crude extracts and pure compounds to explore novel bioactive compounds for therapeutic application. Aegle marmelos (L.) is a seasonal fruit that contains significant amounts of bioactives like, phenolic acids (gallic acids, 2,3-dihydroxy benzoic acid, chlorogenic acid, p-coumaric acid, vanillic acid), flavonoid (rutin), organic acids (oxalic acid, tartaric acid, malic acid, lactic acid, acetic acid, citric acid, propionic acid, succinic acid, fumaric acid), vitamin C, vitamin B group (thiamine, niacin, pyridoxine, pantothenic acid, biotin, cobalamins, riboflavin), tocopherols (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol), carotenes (α-carotene, β-carotene, γ-carotene, δ-carotene) and also rich in essential minerals (potassium, calcium, phosphorus, sodium, iron, copper, manganese). Hence the use of aegle plays important role as anti-inflammatory.

Formulation Development and Evaluation of Fast Disintegrating Sustained Release Pellets Containing Verapamil Hydrochloride Tablets by Fluidized Bed Processor

This study aimed to developed novel fast disintegrating sustained release pellets containing tablet by using Fluidized Bed processor. Verapamil HCl used as a model drug for the formulation. Fluidized bed processor was used for coating of drug and polymer on the sugar spheres. To overcome the problem of swallowing for paediatric, geriatric, psychiatric, bedridden patients, uncooperative patients or for active patients who are busy and travelling and may not access to we aim to formulate the fast-disintegrating tablet. The superdisintigrant are commonly use like cross povidone, sodium starch glycolate which disintegrate tablet rapidly. It is assumed that, after the disintegration of tablets, pellets within tablets which are reside in GIT for several hours and gradually released a drug in controlled way. Eudragit RS 30D and ethyl cellulose were used as a sustained release polymer. Coating of spheres with sustained release film is achieved by bottom spray processor of FBP. Proper pellets coating film thickness, and concentration of polymers’, ensure obtaining desirable VH release profile for extended period of time, was defined. X composition of tablet with pellets were examined in order to obtained formulation, from which VH release would mostly appropriate pellets before compressing. Compression of pellets into tablet, being a modern technological process than enclosing them into hard gelatine capsule. The optimized batch evaluated by studied the effect of compression force, tablet hardness and friability and drug release from the pellets by sustained release manner.

Role of Vitamins, Minerals and Herbs in Strengthening immune system against the newly Emerging Viral Disease SARS-CoV-2

The Coronavirus Disease 2019 (COVID-19) is caused by severe acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection Attack mainly on the immune system of the body. The current pandemic situation of COVID-19 has broken the social-economical Condition of the World. The Available Allopathic drug Paramedical system is attempting to manage the symptoms. But, there are no significant effects of the available drug system. So, it is better to move toward a supplement system that improves the body's immune system. Herbs, Minerals, and Vitamins can be boosting body immunity and prevent the respiratory Viral Disease SARS-CoV-2. It gives its response in the Primary Stage of COVID-19. So, it is better to towards the natural herbals, Minerals, and vitamins which can improve the immunity of the body and it can possibly prevent the viral infection.

Melphalan flufenamide is an Anticancer medication used to treat multiple Myeloma: A Review

Melphalan Flufenamide is a peptide-drug conjugate composed of a peptide conjugated, via an aminopeptidase-targeting linkage, to the alkylating agent melphalan, with potential antineoplastic and anti-angiogenic activities. Upon administration, the highly lipophilic melphalan flufenamide penetrates cell membranes and enters cells. In aminopeptidase-positive tumor cells, melphalan flufenamide is hydrolyzed by peptidases to release the hydrophilic alkylating agent melphalan. This results in the specific release and accumulation of melphalan in aminopeptidase-positive tumor cells. Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages. This results in the inhibition of DNA and RNA synthesis and the induction of apoptosis, thereby inhibiting tumor cell proliferation. Peptidases are overexpressed by certain cancer cells. The administration of melphalan flufenamide allows for enhanced efficacy and reduced toxicity compared to melphalan.1,2,3

Phyto-Pharmacological Profile of Wrightia tinctoria

Wrightia tinctoria is a medium sized ever green tree grows up to 18 m tall and to 20 cm which produces milky white latex from the leaves which is directly applied on inflammation. Since from ancient period this plant constantly been used as a source of medicine. This plant shows a very important component of the health care system in India. In ayurvedic system the drug activity of W.tinctoria is defined as titka, kashaya, rooksha, sita and katu. Various parts of this plant such as stem bark, leaves, flowers also seed have been known to have medicinal assets. Phytochemical studies have shown that it contains alkaloids, triterpenoids, steroids, flavonoids, phenolics, carbohydrates, lipids etc. Wrightia tinctoria has been allotted to have good analgesic, anti-inflammatory, anthelmintic, antiulcer, antidysentric, antidiabetic, anticancer, antipyretic activities as well as active in the treatment of psoriasis. The present review primed to describe the botanical classification, vernacular names, species, Pharmacognostical and Phytochemical Properties and pharmacological activities of the plant Wrightia tinctoria.

Floating Drug Delivery System: An Overview

In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The recent developments in floating drug delivery systems are containing the physiological and formulation variables impacting on gastric retention time, approaches to formulating of single-unit and multiple-unit floating systems, and their classification and formulation aspects are discussed in detail. This review also summarizes evaluation parameters and application of floating drug delivery systems.