Towards the total synthesis of chondrochloren A: synthesis of the (Z)-enamide fragment
Keyword(s):
The stereoselective synthesis of the (Z)-enamide fragment of chondrochloren (1) is described. A Buchwald-type coupling between amide 3 and (Z)-bromide 4 was used to generate the required fragment. The employed amide 3 comprising three chiral centers was obtained through a seven-step sequence starting from ᴅ-ribonic acid-1,4-lactone. The (Z)-vinyl bromide 4 is accessible in four steps from 4-hydroxybenzaldehyde. The pivotal cross coupling between both fragments was achieved after extensive experimentation with copper(I) iodide, K2CO3 and N,N′-dimethylethane-1,2-diamine.
2018 ◽
Keyword(s):
2014 ◽
Vol 55
(31)
◽
pp. 4295-4297
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2014 ◽
Vol 12
(36)
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pp. 7026-7035
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