scholarly journals Recent advances in transition-metal-catalyzed intermolecular carbomagnesiation and carbozincation

2013 ◽  
Vol 9 ◽  
pp. 278-302 ◽  
Author(s):  
Kei Murakami ◽  
Hideki Yorimitsu
Keyword(s):  
Transition Metal ◽  
Transition Metals ◽  
Recent Advances ◽  
Group 3 ◽  
Directing Group ◽  
Transition Metal Catalyzed ◽  
Electron Withdrawing Group ◽  
Group 2 ◽  
Metal Catalyzed ◽  
Organozinc Reagents

Carbomagnesiation and carbozincation reactions are efficient and direct routes to prepare complex and stereodefined organomagnesium and organozinc reagents. However, carbon–carbon unsaturated bonds are generally unreactive toward organomagnesium and organozinc reagents. Thus, transition metals were employed to accomplish the carbometalation involving wide varieties of substrates and reagents. Recent advances of transition-metal-catalyzed carbomagnesiation and carbozincation reactions are reviewed in this article. The contents are separated into five sections: carbomagnesiation and carbozincation of (1) alkynes bearing an electron-withdrawing group; (2) alkynes bearing a directing group; (3) strained cyclopropenes; (4) unactivated alkynes or alkenes; and (5) substrates that have two carbon–carbon unsaturated bonds (allenes, dienes, enynes, or diynes).

scholarly journals Transition metal-catalyzed synthesis of spirooxindoles

RSC Advances ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 7146-7179
Author(s):  
P. V. Saranya ◽  
Mohan Neetha ◽  
Thaipparambil Aneeja ◽  
Gopinathan Anilkumar
Keyword(s):  
Transition Metal ◽  
Transition Metals ◽  
Antimicrobial Agents ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Spirooxindoles are used as anticancer-, antiviral-, antimicrobial agents etc. The use of transition metals as catalysts for the synthesis of spirooxindoles is advancing rapidly. Here, we focus on recent advances in transition metal-catalyzed synthesis of spirooxindoles.

Directing-Group-Assisted Transition-Metal-Catalyzed Direct C–H Oxidative Annulation of Arenes with Alkynes for Facile Construction of Various Oxygen Heterocycles

Synthesis ◽  
2020 ◽  
Vol 52 (07) ◽  
pp. 993-1006 ◽  
Author(s):  
Guanghua Kuang ◽  
Guangyuan Liu ◽  
Xingxing Zhang ◽  
Naihao Lu ◽  
Yiyuan Peng ◽  
...  
Keyword(s):  
Transition Metal ◽  
Noble Metals ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Research Papers ◽  
Recent Advances ◽  
Oxygen Heterocycles ◽  
Directing Group ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

The most recent advances in the construction of oxygen heterocycles by the directing-group-assisted transition-metal-catalyzed direct oxidative annulation of arenes with diverse alkynes are summarized in this review. More than 140 recent research papers and many closely related reviews are referenced in this paper. Nine different oxygen heterocycles frameworks are discussed. Several traditional transition-metal catalysts as well as some classical non-noble metals are utilized to promote the annulation. Three plausible controlling models are disclosed to clarify the excellent regioselectivity outcomes achieved in case of unsymmetrical alkyne substrates.1 Introduction2 Coumarins3 I socoumarins and Their Analogues4 2-Pyrones and Their Analogues5 Chromones and Chroman-4-ones6 Chromenes and Isochromenes7 Fused Polycyclic Oxygen Heteroaromatics8 Benzofurans, Dihydrobenzofurans, and Furans9 Phthalides and Benzofuranones10 Benzoxepines11 Conclusion

Phosphorus-Containing Groups Assisted Transition Metal Catalyzed C-H Activation Reactions

2019 ◽  
Vol 23 (2) ◽  
pp. 103-135 ◽  
Author(s):  
Chun-Ni Zhou ◽  
Zi-Ang Zheng ◽  
George Chang ◽  
Yuan-Chao Xiao ◽  
Yang-Huan Shen ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Mechanistic Study ◽  
Recent Advances ◽  
Phosphorus Containing ◽  
Directing Group ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Over the last few decades, transition metal-catalyzed direct C-H activation with the assistance of a coordinating directing group has emerged as an atom- and stepeconomical synthetic tools to transform C–H bonds into carbon-carbon or carbonheteroatom bonds. Although the strategies involving regioselective C–H cleavage assisted by various directing groups have been extensively reviewed in the literature, we now attempt to give an overview of the recent advances on phosphorus-containing functional group assisted C-H activation reactions catalyzed by transition-metal catalysts including mechanistic study and synthetic applications. The discussion is directed towards C-H olefination, C-H activation/cyclization, C-H arylation, C-H amination, C-H hydroxylation and acetoxylation as well as miscellaneous C-H activation.

scholarly journals Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage

2019 ◽  
Vol 15 ◽  
pp. 1612-1704 ◽  
Author(s):  
Gagandeep Kour Reen ◽  
Ashok Kumar ◽  
Pratibha Sharma
Keyword(s):  
Transition Metal ◽  
Transition Metals ◽  
Method Development ◽  
Deep Understanding ◽  
Catalyst Loading ◽  
Coupling Reactions ◽  
Reaction Conditions ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

A comprehensive account of recent advances in the synthesis of imidazopyridines, assisted through transition-metal-catalyzed multicomponent reactions, C–H activation/functionalization and coupling reactions are highlighted in this review article. The basic illustration of this review comprises of schemes with concise account of explanatory text. The schemes depict the reaction conditions along with a quick look into the mechanism involved to render a deep understanding of the catalytic role. At some instances optimizations of certain features have been illustrated through tables, i.e., selectivity of catalyst, loading of the catalyst and percentage yield with different substrates. Each of the reported examples has been rigorously analyzed for reacting substrates, reaction conditions and transition metals used as the catalyst. This review will be helpful to the chemists in understanding the challenges associated with the reported methods as well as the future possibilities, both in the choice of substrates and catalysts. This review would be quite appealing to a wider range of organic chemists in academia and industrial R&D sectors working in the field of heterocyclic syntheses. In a nutshell, this review will be a guiding torch to envisage: (i) the role of various transition metals in the domain dedicated towards method development and (ii) for the modifications needed thereof in the R&D sector.

scholarly journals Recent Advances in Transition-Metal-Catalyzed Directing Group Assisted Nitration of Inert C-H Bonds

2019 ◽  
Vol 39 (2) ◽  
pp. 318 ◽  
Author(s):  
Huicheng Cheng ◽  
Jinlong Lin ◽  
Yaofeng Zhang ◽  
Bing Chen ◽  
Min Wang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Directing Group ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Chelation-assisted transition metal-catalysed C–H chalcogenylations

2020 ◽  
Vol 7 (8) ◽  
pp. 1022-1060 ◽  
Author(s):  
Wenbo Ma ◽  
Nikolaos Kaplaneris ◽  
Xinyue Fang ◽  
Linghui Gu ◽  
Ruhuai Mei ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Site Selectivity ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

Recent advances in transition metal-catalyzed asymmetric electrocatalysis

2021 ◽  
Vol 444 ◽  
pp. 214065
Author(s):  
Priyanka Chakraborty ◽  
Rajib Mandal ◽  
Nidhi Garg ◽  
Basker Sundararaju
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Biaryl Synthesis via Electrooxidative Transition Metal Catalyzed C−H Activation

Synthesis ◽  
2021 ◽  
Author(s):  
Jonas Felix Goebel ◽  
Zhongyi Zeng ◽  
Lukas Goossen
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Biaryl Synthesis ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

The use of electricity as an inexpensive and waste-free oxidant opens up new opportunities for the development of sustainable C–H functionalization reactions. Herein we summarize recent advances in the synthesis of biaryls through electrooxidative processes involving transition metal catalyzed ortho-directed C−H activation. A particular focus is set on electrooxidative C−H/C−M couplings and dehydrogenative couplings.

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