Synthesis of halogenated bicyclic molecules involving Prins cyclization from aldehydes and non-conjugated diene alcohol
Keyword(s):
Scale Up
◽
The reactions of aldehydes and a non-conjugated alcohol, (E)-octa-3,7-dien-1-ol, in the presence of halogen-containing reagents afforded the corresponding halogenated bicyclic molecules in good yields. The optimization, scope and limitations of the reactions as well as scale-up reactions have been examined. Quantum chemical calculations helped clarify the microscopic mechanism of a key reaction process, the introduction of a Cl atom to a bicyclic carbocation.
1987 ◽
Vol 152
(3-4)
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pp. 357-359
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Keyword(s):
2015 ◽
Vol 135
(10)
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pp. 618-623
2020 ◽
2020 ◽
2020 ◽
Vol 16
(2)
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pp. 93-103
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