Introductory letter from the Editor-in-Chief

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU (Received 9 February 1978) It has been shown that prostaglandins play an important role in the mechanism of parturition in many species, including the goat (Currie & Thorburn, 1977; Thorburn, Challis & Robinson, 1977). Recently we have demonstrated that intra-uterine tissues from pregnant goats, when superfused in vitro, produce prostaglandins E and F (PGE, PGF) and 13,14-dihydro-15-oxo-prostaglandin F at various rates (Mitchell, Flint, Robinson & Thorburn, 1978). The exciting discoveries of two potent prostaglandin-like compounds, thromboxane A2 (TXA2; Hamberg, Svensson & Samuelsson, 1975) and prostacyclin (PGI2; Moncada, Gryglewski, Bunting & Vane, 1976), have radically altered our thinking on prostaglandins and basic data are urgently required concerning these compounds. Since prostaglandin endoperoxides are the immediate precursors of both prostaglandins and TXA2 (and PGI2) and since TXA2 has been shown to cause contraction of a number

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EFFECT OF SOMATOSTATIN ON THE CONCENTRATION OF GROWTH HORMONE IN THE PLASMA OF FOETAL SHEEP

Journal of Endocrinology ◽

10.1677/joe.0.0780453 ◽

1978 ◽

Vol 78 (3) ◽

pp. 453-454 ◽

Cited By ~ 5

Author(s):

I. C. McMILLEN ◽

G. JENKIN ◽

G. D. THORBURN ◽

J. S. ROBINSON

Keyword(s):

Growth Hormone ◽

Pituitary Gland ◽

Medical Research ◽

Pituitary Stalk ◽

Obstetrics And Gynaecology ◽

Nuffield Department ◽

John Radcliffe Hospital ◽

Ovine Placenta

Nuffield Institute for Medical Research and Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford, 0X3 9DU (Received 6 April 1978) Growth hormone (GH) has been located in the ovine foetal pituitary gland by day 50 of gestation (Stokes & Boda, 1968). The concentration of GH in the plasma of foetal sheep is ten times higher than the postnatal value, increasing from 40 ng/ml on day 100 of gestation to 100–120 ng/ml on day 140 (Bassett, Thorburn & Wallace, 1970). After foetal hypophysectomy, the concentration of GH falls to < 2 ng/ml, indicating that it originates in the foetal pituitary gland (Wallace, Stacey & Thorburn, 1973). Labelled GH does not cross the ovine placenta (Wallace et al. 1973). After sectioning the foetal pituitary stalk, the concentration of GH in the foetal plasma drops to approximately 5 ng/ml (Wallace et al. 1973), which implies that the secretion of GH

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Trichlorethylene anæsthesia. By GORDON OSTLERE, M.A., M.B., B. Chir. (Camb.), D.A., Deputy First Assistant, Nuffield Department of Anæsthetics, University of Oxford. 4 7/8 × 7 1/4 in. Pp. 83 + viii, with 5 illustrations. 1953. Edinburgh: E. & S. Livingstone Ltd. 7s. 6d.

British Journal of Surgery ◽

10.1002/bjs.18004016437 ◽

1953 ◽

Vol 40 (164) ◽

pp. 631-631

Keyword(s):

University Of Oxford ◽

Nuffield Department

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LOCAL ANALGESIA: HEAD AND NECK. By Sir Robert Macintosh, D.M., F.R.C.S. (Edin.), F.F.A.R.C.S., Nuffield Professor of Anaesthetics, University of Oxford; and Mary Ostlere, M.B., M.R.C.P.E., F.F.A.R.C.S., Research Assistant, Nuffield Department of Anaesthetics, University of Oxford. Illustrated by Marjorie Beck. 9x6 in. Pp. viii+138, with 145 figures. Index. 1955. Edinburgh and London: E. & S. Livingstone Ltd. Price 27s. 6d

Journal of Bone and Joint Surgery - British Volume ◽

10.1302/0301-620x.38b2.607-a ◽

1956 ◽

Vol 38-B (2) ◽

pp. 607-607

Author(s):

D. Ll. Griffiths

Keyword(s):

Head And Neck ◽

Local Analgesia ◽

Research Assistant ◽

University Of Oxford ◽

Nuffield Department

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Kennard, Prof. Christopher, (born 5 Jan. 1946), Professor of Clinical Neurology, and Head, Nuffield Department of Clinical Neurosciences (formerly Department of Clinical Neurology), 2008–16, now Professor Emeritus, and Head, Medical Sciences Division, since 2017, University of Oxford; Senior Kurti Fellow, Brasenose College, Oxford, since 2009

10.1093/ww/9780199540884.013.22845 ◽

2007 ◽

Keyword(s):

Professor Emeritus ◽

Clinical Neurology ◽

Medical Sciences ◽

University Of Oxford ◽

Nuffield Department

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Collins, Sir Rory (Edwards), (born 3 Jan. 1955), Co-director, Clinical Trial Service Unit and Epidemiological Studies Unit, since 1986, British Heart Foundation Professor of Medicine and Epidemiology, since 1996, Nuffield Professor of Population Health, since 2016, and Head, Nuffield Department of Population Health, since 2013, University of Oxford; Fellow, St John’s College, Oxford, since 2016

10.1093/ww/9780199540884.013.253774 ◽

2011 ◽

Keyword(s):

Clinical Trial ◽

Population Health ◽

Epidemiological Studies ◽

British Heart Foundation ◽

Service Unit ◽

University Of Oxford ◽

Nuffield Department ◽

Heart Foundation

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Kennard, Prof. Christopher, (born 5 Jan. 1946), Professor of Clinical Neurology, and Head, Nuffield Department of Clinical Neurosciences (formerly Department of Clinical Neurology), University of Oxford, 2008–16, now Professor Emeritus; Senior Kurti Fellow, Brasenose College, Oxford, since 2009

10.1093/ww/9780199540884.013.u22845 ◽

2007 ◽

Keyword(s):

Professor Emeritus ◽

Clinical Neurology ◽

University Of Oxford ◽

Nuffield Department

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Russell, Prof. (Robert) Graham (Goodwin), (born 16 Feb. 1941), Professor of Musculoskeletal Pharmacology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (formerly Nuffield Department of Orthopaedic Surgery), University of Oxford, since 2006 (Norman Collisson Professor of Musculoskeletal Science, 2000–06); Fellow of St Peter’s College, Oxford, 2001–07, now Emeritus; Professor of Musculoskeletal Pharmacology, Mellanby Centre for Bone Research, University of Sheffield Medical School, since 2009

10.1093/ww/9780199540884.013.u44346 ◽

2007 ◽

Keyword(s):

Medical School ◽

Orthopaedic Surgery ◽

Research University ◽

Emeritus Professor ◽

University Of Oxford ◽

Nuffield Department ◽

Bone Research

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Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies

Cells ◽

10.3390/cells11010127 ◽

2021 ◽

Vol 11 (1) ◽

pp. 127

Author(s):

Wendy N. Erber

Keyword(s):

Bone Marrow ◽

Alkaline Phosphatase ◽

Monoclonal Antibodies ◽

University Of Oxford ◽

Alkaline Phosphatase Staining ◽

Nuffield Department ◽

Staining Methods ◽

Biological Discovery ◽

The University ◽

Productive Time

I reflect on my experience working with David Y. Mason in the Leukaemia Research Laboratories in the Nuffield Department of Pathology at the University of Oxford in the early 1980s. This was soon after the first monoclonal antibodies had been produced, which led to an exciting and productive time in biological discovery and pathology diagnostics. A specific focus in the laboratory was the development of immunoenzymatic staining methods that would enable monoclonal antibodies to be applied in diagnostic practice. This paper describes the work that led to the performance of immuno-alkaline phosphatase staining on blood and bone marrow smears, the success of which changed leukaemia diagnosis.

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