scholarly journals Introductory letter from the Editor-in-Chief

2020 ◽  
Vol 1 (3) ◽  
Author(s):  
Ashok Handa
Keyword(s):  
Nuffield Department

Welcome to Volume 1 Issue 3 of Journal of Nuffield Department of Surgical Sciences!

PRODUCTION OF THROMBOXANE B2 BY INTRA-UTERINE TISSUES FROM PREGNANT GOATS IN VITRO

1978 ◽  
Vol 78 (1) ◽  
pp. 159-160 ◽  
Author(s):  
M. D. MITCHELL ◽  
A. P. F. FLINT ◽  
E. J. KINGSTON ◽  
G. D. THORBURN ◽  
J. S. ROBINSON
Keyword(s):  
Thromboxane B2 ◽  
Basic Data ◽  
University Of Oxford ◽  
Obstetrics And Gynaecology ◽  
Nuffield Department ◽  
John Radcliffe Hospital ◽  
Prostaglandin F ◽  
Prostaglandins E

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU (Received 9 February 1978) It has been shown that prostaglandins play an important role in the mechanism of parturition in many species, including the goat (Currie & Thorburn, 1977; Thorburn, Challis & Robinson, 1977). Recently we have demonstrated that intra-uterine tissues from pregnant goats, when superfused in vitro, produce prostaglandins E and F (PGE, PGF) and 13,14-dihydro-15-oxo-prostaglandin F at various rates (Mitchell, Flint, Robinson & Thorburn, 1978). The exciting discoveries of two potent prostaglandin-like compounds, thromboxane A2 (TXA2; Hamberg, Svensson & Samuelsson, 1975) and prostacyclin (PGI2; Moncada, Gryglewski, Bunting & Vane, 1976), have radically altered our thinking on prostaglandins and basic data are urgently required concerning these compounds. Since prostaglandin endoperoxides are the immediate precursors of both prostaglandins and TXA2 (and PGI2) and since TXA2 has been shown to cause contraction of a number

EFFECT OF SOMATOSTATIN ON THE CONCENTRATION OF GROWTH HORMONE IN THE PLASMA OF FOETAL SHEEP

1978 ◽  
Vol 78 (3) ◽  
pp. 453-454 ◽  
Author(s):  
I. C. McMILLEN ◽  
G. JENKIN ◽  
G. D. THORBURN ◽  
J. S. ROBINSON
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Medical Research ◽  
Pituitary Stalk ◽  
Obstetrics And Gynaecology ◽  
Nuffield Department ◽  
John Radcliffe Hospital ◽  
Ovine Placenta

Nuffield Institute for Medical Research and Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford, 0X3 9DU (Received 6 April 1978) Growth hormone (GH) has been located in the ovine foetal pituitary gland by day 50 of gestation (Stokes & Boda, 1968). The concentration of GH in the plasma of foetal sheep is ten times higher than the postnatal value, increasing from 40 ng/ml on day 100 of gestation to 100–120 ng/ml on day 140 (Bassett, Thorburn & Wallace, 1970). After foetal hypophysectomy, the concentration of GH falls to < 2 ng/ml, indicating that it originates in the foetal pituitary gland (Wallace, Stacey & Thorburn, 1973). Labelled GH does not cross the ovine placenta (Wallace et al. 1973). After sectioning the foetal pituitary stalk, the concentration of GH in the foetal plasma drops to approximately 5 ng/ml (Wallace et al. 1973), which implies that the secretion of GH

scholarly journals Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies

Cells ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 127
Author(s):  
Wendy N. Erber
Keyword(s):  
Bone Marrow ◽  
Alkaline Phosphatase ◽  
Monoclonal Antibodies ◽  
University Of Oxford ◽  
Alkaline Phosphatase Staining ◽  
Nuffield Department ◽  
Staining Methods ◽  
Biological Discovery ◽  
The University ◽  
Productive Time

I reflect on my experience working with David Y. Mason in the Leukaemia Research Laboratories in the Nuffield Department of Pathology at the University of Oxford in the early 1980s. This was soon after the first monoclonal antibodies had been produced, which led to an exciting and productive time in biological discovery and pathology diagnostics. A specific focus in the laboratory was the development of immunoenzymatic staining methods that would enable monoclonal antibodies to be applied in diagnostic practice. This paper describes the work that led to the performance of immuno-alkaline phosphatase staining on blood and bone marrow smears, the success of which changed leukaemia diagnosis.

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