Aim of the study. To analyze the effectiveness and safety of cytoreductive interventions in patients with IV stage colorectal cancer in account of the age factor and to assess the effect of the molecular biological properties of the tumor on long-term treatment results. Materials and methods. A comparative evaluation of the results of surgical treatment of metastatic colorectal cancer in patients of various age groups was carried out. The clinical significance of immunohistochemical markers for predicting long-term treatment outcomes has been studied. Results. The most significant risk factors for the development of postoperative complications were identified. The prognostic value of immunohistochemical markers such as the proliferative index of stem cancer cells (ALDH + Ki-67 +) and the chemokine receptor CXCR4 has been established. Conclusion. A comprehensive analysis of the molecular biological properties of the tumor, coupled with an assessment of the functional operability of patients, provides a personalized approach to the choice of surgical tactics in patients with stage IV colorectal cancer, which allows counting on the encouraging results of cytoreductive interventions.
Durable response using regorafenib in an elderly patient with metastatic colorectal cancer: case report
