Predicting Physical Appearance from DNA Data—Towards Genomic Solutions

The idea of forensic DNA intelligence is to extract from genomic data any information that can help guide the investigation. The clues to the externally visible phenotype are of particular practical importance. The high heritability of the physical phenotype suggests that genetic data can be easily predicted, but this has only become possible with less polygenic traits. The forensic community has developed DNA-based predictive tools by employing a limited number of the most important markers analysed with targeted massive parallel sequencing. The complexity of the genetics of many other appearance phenotypes requires big data coupled with sophisticated machine learning methods to develop accurate genomic predictors. A significant challenge in developing universal genomic predictive methods will be the collection of sufficiently large data sets. These should be created using whole-genome sequencing technology to enable the identification of rare DNA variants implicated in phenotype determination. It is worth noting that the correctness of the forensic sketch generated from the DNA data depends on the inclusion of an age factor. This, however, can be predicted by analysing epigenetic data. An important limitation preventing whole-genome approaches from being commonly used in forensics is the slow progress in the development and implementation of high-throughput, low DNA input sequencing technologies. The example of palaeoanthropology suggests that such methods may possibly be developed in forensics.

The Correlation of Maternal Age and the Incidence of Preeclampsia at Aura Syifa Hospital

Preeclampsia is a condition when hypertension and proteinuria occurs after 20 weeks of pregnancy. The exact cause of preeclampsia is currently unknown, but many factors influence the occurrence of preeclampsia, especially the age factor. This study was aimed to determine the correlation between maternal age and the incidence of preeclampsia. This study was analytical survey designed with retrospective study method. From Aura Syifa hospital, 142 medical records in of pregnant women in 2017 were taken 105 samples by using simple random sampling technique. The result of this study indicated that delivered mothers who were in reproductive age (20-35 years old), 25.8% of them had preeclampsia and 31,1% had severe preeclampsia. The data analyzed by suing chi-square correlation and the result was ρ (0.00) < α (0.05) which meant that there was a correlation between maternal age and the incidence of preeclampsia. It would be better for couples planning pregnancy in healthy reproductive age for minimize the risk of preeclampsia.

Modeling the influence of age on the technical efficiency by sector and time periods

In today’s competitive economy, technological leadership and technical efficiency are key to the successful development of enterprises, countries and territories. This paper investigates the influence of factors on the technical efficiency of a business. Situations where technical efficiency is calculated by the DEA method, and its determinants are defined in regression models, including tobit regression models, have been considered. The determinants of technical efficiency identified by foreign researchers have been systematised. Modeling of the influence of the “Age” factor on the technical efficiency of enterprises in six leading sectors of Russia’s economy over the period 2015–2019 has been performed. It has been found that the “Age” factor has different effects on technical efficiency in different industry sectors. Particularly, in the food industry younger companies are more technically efficient, while mature companies are more technically efficient in the information technology sector. Accordingly, the directions and priorities for incentives should differ across sectors of the economy. In particular, the technological development of the food industry requires support for the generation processes of young enterprises and start-ups. In the information technology sector, the priority should be to support mature enterprises and the growth processes of young enterprises to maturity.

The object detection system of balinese script on traditional Balinese manuscript with findcontours method

Lontar is a traditional Balinese manuscript with a Balinese script in it. Balinese traditional manuscripts can be more than 100 years old. The age factor of the Balinese manuscript has an impact on the Balinese script in it. Balinese script that has been written more than 10 years tends to be darker. This makes Balinese script not visible well, and this affects the image quality of the manuscript. This thing becomes the main issue in this research, Balinese script detection on Balinese manuscript images. the first of all is image processing using edge detection, canny and Sobel becomes the main algorithm of this process. After image processing, the Balinese manuscript will be processed with the findcontour method to detect an object that contains in it. The final process of this detection system is to separate detected objects into three main groups namely noise object, Balinese script object, and hole object. Application (Balinese script object detection system) is more accurate in detecting Balinese script objects in Balinese script under 1 year (new script), it tends to be more likely to find noise/dirt. This is because the writing of the lontar using a pencil first before using the knife media. This adds to the noise or dirt detected by the application The findcontour method can detect Balinese script objects with a detection result of 30% - 70% Balinese script objects.

PECULIARITIES OF ONYCHOMYCOSIS COURSE AND TREATMENT AT PRESENT

The article provides an overview of current data from the scientific literature on the epidemiological features of onychomycosis at present, including changes in the spectrum of pathogens, the nature of the course and clinical manifestations of fungal nail lesions. Current data on the characteristic manifestation of onychomycosis point out the importance of age factor: age-related changes in old population are associated with involutional processes in the skin and its appendages, decreased growth rate of nails, angiopathy, etc. This review demonstrated the relationship between chronic dermatoses and onychomycosis. In chronic dermatoses, including psoriasis, eczema, etc., there are fungal lesions of the nail plates, which cause not only the progression of trophic disorders, increased dryness of the skin and violation of its integrity, but also sensitization of the patient. Onychomycosis complicates the course of chronic dermatoses. In the absence of onychomycosis treatment there is a significant risk of complete destruction of the nail plates with further involvement of the adjacent skin in the pathological process and infection spreading. Three components of effective therapy are identified: accurate diagnosis, correctly selected therapy and compliance. This article also provides the brief description of existing treatment methods of onychomycosis ranging from monotherapy with systemic antifungals to the combined use of systemic and topical antifungals, as well as the use of non-medicinal methods, and in particular methods of ultraphonophoresis, electrophoresis and photodynamics.

TIME PERSPECTIVE PERCEPTION SPECIFIC AND MALADAPTATION IN ELDERLY UNDER UNCERTAINTY CONDITIONS DURING PANDEMIC EMERGENCY

Цель исследования - определение специфики переживания психологического стресса, временной перспективы и симптоматики адаптационных нарушений у пожилых людей в чрезвычайной ситуации пандемии по сравнению с активным взрослым населением. На первом этапе были обследованы 587 человек с помощью шкалы PSM-25, затем были отобраны 100 респондентов с дезадаптационным уровнем стресса (сумма ≥155 баллов). Основную группу составили 50 человек 60-74 лет (средний возраст - 65±2,7 года), 50 человек 18-44 лет (средний возраст - 32±3,8 года) вошли в группу сравнения, которые были обследованы с помощью опросника SCL-90-R для оценки психопатологической симптоматики и опросника ZTPI для оценки восприятия временной перспективы. Выявлено наличие адаптационных расстройств в обеих группах. В группе пожилых установлена активация восприятия позитивного прошлого, что может быть адаптационным ресурсом, и большая выраженность фаталистического восприятия настоящего, что обусловливает пассивное преодоление стресса и сужает адаптационные возможности пожилых людей. Результаты исследования позволяют обозначить потенциальные «мишени» психотерапевтической работы с населением в условиях пандемического стресса с учетом возрастного фактора. The purpose of the study - to determine the specifics of experiencing psychological stress, the time perspective and symptoms of adaptation disorders in older people in a pandemic emergency compared to the active adult population. At the first stage, 587 people were examined using the PSM-25 scale, then 100 respondents with maladaptive stress levels (sum ≥155 points) were selected. The main group consisted of 50 people aged 60 to 74 years (aver age age 65±2,7 years), 50 people aged 18 to 44 years (average age 32±3,8 years) were included in comparison group, who were examined with using the SCL-90-R questionnaire for assessing psychopathological symptoms and the ZTPI questionnaire for assessing the perception of time perspective. The presence of adaptation disorders in both groups was revealed. In the elderly group, the activation of the perception of the positive past was established, which can be an adaptive resource, and the greater severity of the fatalistic perception of the present, which causes passive overcoming with stress and narrows the adaptive capabilities of the elderly. The results of the study make it possible to identify potential «targets» of psychotherapeutic work with the population in conditions of pandemic stress, taking into account the age factor.

FAKTOR YANG MEMPENGARUHI KEJADIAN INFEKSI POST OPERASI DI RUANG RANAP WIJAYA KUSUMAH RSUD KOTA BANJAR

Status gizi, usia dan faktor ekonomi merupakan faktor internal pasien yang mempengaruhi frekuensi infeksi. Masyarakat masih belum mengetahui status gizinya dan tidak dapat memperbaikinya, dengan penyebab yang bervariasi baik dari keadaan ekonomi maupun dari kurangnya pengetahuan masyarakat tentang gizi. Faktor internal lain dalam frekuensi infeksi adalah usia, pada pasien yang lebih tua dari 70 tahun. Faktor usia di atas 70 dapat menurunkan pertahanan tubuh. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi kejadian infeksi post operasi di bangsal Vijaya Kusumah RSUD Kota Banjar. Penelitian ini menggunakan beberapa jenis penelitian korelasi. Populasi penelitian ini terdiri dari seluruh pasien pasca operasi dan sampel sebanyak 21 responden. Alat yang digunakan dalam penelitian ini adalah kuesioner, dan analisis data yang digunakan dalam penelitian ini adalah univariat dan bivariat. Hasil penelitian menunjukkan bahwa tidak ada pengaruh faktor status gizi terhadap kejadian infeksi post operasi, pengaruh faktor status gizi terhadap kejadian infeksi post operasi dan pengaruh faktor ekonomi terhadap kejadian infeksi post operasi. Akibatnya, faktor status gizi tidak mempengaruhi angka infeksi pasca operasi, tetapi faktor status gizi dan tingkat ekonomi ditemukan mempengaruhi angka infeksi pasca operasi. Hasil penelitian ini dimaksudkan untuk digunakan sebagai buku teks dan literatur untuk mengatasi masalah infeksi pasca operasi.Nutritional status, age and economic factors are internal patient factors that affect the frequency of infection. The community still does not know their nutritional status and cannot improve it, with various causes, both from economic conditions and from a lack of public knowledge about nutrition. Another internal factor in the frequency of infection is age, in patients older than 70 years. The age factor over 70 can lower the body's defenses. The purpose of this study was to determine the factors that influence the incidence of postoperative infection in the Vijaya Kusumah ward, Banjar City Hospital. This study uses several types of correlation research. The population of this study consisted of all postoperative patients and a sample of 21 respondents. The instrument used in this study was a questionnaire, and the data analysis used in this study was univariate and bivariate. The results showed that there was no influence of nutritional status factors on the incidence of postoperative infections, the influence of nutritional status factors on the incidence of postoperative infections and the influence of economic factors on the incidence of postoperative infections. As a result, nutritional status factors did not affect postoperative infection rates, but nutritional status factors and economic level were found to influence postoperative infection rates. The results of this study are intended to be used as a textbook and literature to address the problem of postoperative infection.

Sunda Language the Parean Dialect in Kandanghaur District, Indramayu Regency – Indonesia Based on a Dialectology Approach

This research uses one of the branches of linguistics, namely dialectology. Dialectology is the study of forms of language variation seen from a group of people. The geographical location in this study is an area where the majority of people use Javanese, but in that area, there are several villages whose people speak Sundanese. The area is located in Kandanghaur Indramayu – Indonesia. Factors underlying the variety of languages, namely the acculturation of Sundanese and Javanese. in addition, Sundanese people there can use three languages that include Indonesian, Sundanese, and Javanese. Therefore, this research will be aimed at the Sundanese Parean dialect in Kandanghaur Subdistrict located in Indramayu Regency - Indonesia. The location and language chosen to show something interesting, such as the location is the spread of Javanese society, while speakers some use Sundanese. The material used is 16 Sundanesespeaking informants who follow the age factor amounting to 6 people with 3 young people and 3 parents, while the education factor consists of 6 people from 2 elementary schools, 2 people junior high school, and high school. The formal factor uses 4 people, namely 2 formal sectors and 2 non-formal sectors. The research method uses qualitative descriptive, while the data collection method uses the Ayatrohaedi field method (1979:34) and the method of listening to libat is capable with basic techniques, notes, records, fishing, and sadap Mahsun (2015: 91-93). There are many methods of presentation of data utilizing formal and non-formal methods. The results found that there are variations in the Sundanese Parean dialect from aspects that include age, education, and work. The variation is selected and sorted based on the terrain of meaning that has been determined, namely the field of meaning of the limbs, pronouns, and greetings, the terms kinship, the house, and its parts, the time of natural circumstances, and the direction, clothing, and jewelry smell and tastes, plants and fruits, and the word question and greeting. From each field of meaning, it has been found a form of language variation from each social group, so that the Sundanese Parean dialect can be said with a language that has a form of language variation.