scholarly journals Analyzing the genomic integrity of stem cells

StemBook ◽  
2014 ◽  
Author(s):  
Uri Ben-David
Keyword(s):  
Stem Cells ◽  
Genomic Integrity

Protecting genomic integrity in somatic cells and embryonic stem cells

2007 ◽  
Vol 614 (1-2) ◽  
pp. 48-55 ◽  
Author(s):  
Y. Hong ◽  
R.B. Cervantes ◽  
E. Tichy ◽  
J.A. Tischfield ◽  
P.J. Stambrook
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Somatic Cells ◽  
Embryonic Stem ◽  
Genomic Integrity

PRMT5 is required for the maintenance of genomic integrity in hematopoietic stem cells

2017 ◽  
Vol 53 ◽  
pp. S48
Author(s):  
Darren Tan ◽  
Desmond Chin ◽  
Ying Li ◽  
King Pan Ng ◽  
Ayako Nakamura-Ishizu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Genomic Integrity ◽  
Hematopoietic Stem

scholarly journals Genomic Integrity Safeguards Self-Renewal in Embryonic Stem Cells

Cell Reports ◽  
2019 ◽  
Vol 28 (6) ◽  
pp. 1400-1409.e4 ◽  
Author(s):  
Jie Su ◽  
Dandan Zhu ◽  
Zijun Huo ◽  
Julian A. Gingold ◽  
Yen-Sin Ang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Genomic Integrity ◽  
Self Renewal

scholarly journals Maintenance of genome integrity and active homologous recombination in embryonic stem cells

2020 ◽  
Vol 52 (8) ◽  
pp. 1220-1229 ◽  
Author(s):  
Eui-Hwan Choi ◽  
Seobin Yoon ◽  
Young Eun Koh ◽  
Young-Jin Seo ◽  
Keun Pil Kim
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Homologous Recombination ◽  
Embryonic Stem ◽  
S Phase ◽  
Genome Integrity ◽  
Specific Gene ◽  
Genomic Integrity ◽  
Dna Breaks

Abstract Embryonic stem cells (ESCs) possess specific gene expression patterns that confer the ability to proliferate indefinitely and enable pluripotency, which allows ESCs to differentiate into diverse cell types in response to developmental signals. Compared to differentiated cells, ESCs harbor an elevated level of homologous recombination (HR)-related proteins and exhibit exceptional cell cycle control, characterized by a high proliferation rate and a prolonged S phase. HR is involved in several aspects of chromosome maintenance. For instance, HR repairs impaired chromosomes and prevents the collapse of DNA replication forks during cell proliferation. Thus, HR is essential for the maintenance of genomic integrity and prevents cellular dysregulation and lethal events. In addition, abundant HR proteins in the prolonged S phase can efficiently protect ESCs from external damages and protect against genomic instability caused by DNA breaks, facilitating rapid and accurate DNA break repair following chromosome duplication. The maintenance of genome integrity is key to preserving the functions of ESCs and reducing the risks of cancer development, cell cycle arrest, and abnormal replication. Here, we review the fundamental links between the stem cell-specific HR process and DNA damage response as well as the different strategies employed by ESCs to maintain genomic integrity.

scholarly journals Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

2020 ◽  
Vol 46 ◽  
pp. 101803
Author(s):  
Kanika Kanchan ◽  
Kruthika Iyer ◽  
Lisa R Yanek ◽  
Ivan Carcamo-Orive ◽  
Margaret A Taub ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Genomic Integrity ◽  
Induced Pluripotent

scholarly journals Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells

2013 ◽  
Vol 11 (3) ◽  
pp. 1045-1059 ◽  
Author(s):  
Xiaoying Tan ◽  
Xingbo Xu ◽  
Manar Elkenani ◽  
Lukasz Smorag ◽  
Ulrich Zechner ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Genomic Integrity ◽  
Finger Protein
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