This paper presents a dynamically reconfigurable multivariable Micro-Electro-Mechanical Systems (MEMS) sensor array, capable of reconfiguration in real time, to meet the sensing demands of unattended systems operating in highly variable environments, with an emphasis on maintaining operation of these systems in the presence of structural damage. This array is comprised of multiple instances of identical sensors which can be dynamically reconfigured to target a variety of measurands including acceleration, rotational rate, magnetic fields, temperature, air pressure and density. A simulated environment is used to illustrate how the array can be dynamically reconfigured to respond to variations in several of these parameters. Also shown are simulations that demonstrate the ability of such a sensor array to continue operation in the presence of structural damage.