Validation of an HPLC/UV-based method for Salicornia herbacea-derived isorhamnetin-3-O-glucoside and quercetin-3-O-glucoside quantification

2021 ◽  
Vol 64 (3) ◽  
pp. 285-290
Author(s):  
Jun Yeon Park ◽  
Leo Adrianne Paje ◽  
Ki Sung Kang ◽  
Sanghyun Lee
Keyword(s):  
2009 ◽  
Vol 38 (7) ◽  
pp. 902-908 ◽  
Author(s):  
In-Bae Park ◽  
Jeong-Wook Park ◽  
Young-Jae Lee ◽  
Gung-Won Shin ◽  
Hae-Seop Kim ◽  
...  

2008 ◽  
Vol 37 (7) ◽  
pp. 908-913 ◽  
Author(s):  
Jong-Yoon Bae ◽  
La-Young Park ◽  
Shin-Ho Lee

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 483
Author(s):  
Dahae Lee ◽  
Jun Yeon Park ◽  
Sanghyun Lee ◽  
Ki Sung Kang

In this study, we examined the effect of ethanolic extract of Salicornia herbacea (ESH), isorhamnetin 3-O-glucoside (I3G), quercetin 3-O-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC50 value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance.


Meat Science ◽  
2014 ◽  
Vol 97 (4) ◽  
pp. 513-517 ◽  
Author(s):  
Hyun-Wook Kim ◽  
Ko-Eun Hwang ◽  
Dong-Heon Song ◽  
Yong-Jae Kim ◽  
Yun-Bin Lim ◽  
...  
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2014 ◽  
Vol 23 (3) ◽  
pp. 685-691 ◽  
Author(s):  
Jin Young Kim ◽  
Jeong-Yong Cho ◽  
Jae-Hak Moon ◽  
Gyeong-Cheol Choi ◽  
Kang-Deok Lee ◽  
...  

2017 ◽  
Vol 20 (2) ◽  
pp. 140-151 ◽  
Author(s):  
Min Sun Kim ◽  
Ji Yeon Seo ◽  
Jisun Oh ◽  
Yu Kyung Jang ◽  
Choong Hwan Lee ◽  
...  

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