scholarly journals Infective endocarditis due to Granulicatella adiacens: a case report and review

2014 ◽  
Vol 8 (04) ◽  
pp. 548-550 ◽  
Author(s):  
Kanne Padmaja ◽  
Vemu Lakshmi ◽  
Sreevdya Subramanian ◽  
Mamidi Neeraja ◽  
Siva Rama Krishna ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Infective Endocarditis ◽  
Blood Culture ◽  
Treatment Failure ◽  
Female Patient ◽  
Antimicrobial Therapy ◽  
Mortality Rates ◽  
Elderly Female ◽  
Granulicatella Adiacens

Infective endocarditis (IE) caused by nutritionally variant Streptococci (NVS) is associated with high bacteriologic and treatment failure and mortality rates compared to endocarditis caused by other Streptococci. With automated blood culture systems, the rates of NVS-associated IE accounts for 5%-6% cases. We report a case of IE caused by NVS in an elderly female patient with no risk factors. The patient was successfully treated with combination antimicrobial therapy.

scholarly journals Association of polymorphic variants of xenobiotic biotransformation genes and glutation metabolizing genes with clinical course of cystic fibrosis, antimicrobial therapy efficacy and adverse reactions

2020 ◽  
pp. 64-65
Author(s):  
О.Г. Новоселова ◽  
Е.И. Кондратьева ◽  
Н.В. Петрова ◽  
В.Д. Шерман ◽  
А.Ю. Воронкова ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cystic Fibrosis ◽  
Treatment Failure ◽  
Antimicrobial Therapy ◽  
Adverse Reactions ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Therapy Efficacy ◽  
Xenobiotic Biotransformation ◽  
Polymorphic Variants

Тяжесть клинических проявлений муковисцидоза может быть обусловлена действием генов-модификаторов. Выяснение причин неэффективности терапии и нежелательных побочных реакций, определение факторов риска позволит улучшить прогноз для данной категории больных. Исследованы ассоциации 18 полиморфных вариантов 10 генов ферментов первой и второй фазы биотрансформации ксенобиотиков: CYP2C9 (c.430C>T, c.1075A> C), CYP2C19 (c.681G>A), CYP2D6 (1846G>A), CYP3A4 (c-392C>T), GSTT1 (del), GSTM1 (del), GSTP1 (c.313A>C), GCLC (TVR GAG, c.-129C>T), GCLM (c.-588C>T), NAT2 (c.282C>T, c.341T>C, c.434A>C, c.481C>T, c.590G>A, c.845A>C, c.857G>A) с тяжестью клинических проявлений муковисцидоза. CF clinical variability could be associated with interaction of modifier genes. Сlarification of the causes of treatment failure and adverse reactions, prediction of risk factors could improve the outcome of therapy. Association of 18 polymorphic variants of 10 genes of xenobiotic biotransformation: CYP2C9 (c.430C>T, c.1075A> C), CYP2C19 (c.681G>A), CYP2D6 (1846G>A), CYP3A4 (c-392C>T), GSTT1 (del), GSTM1 (del), GSTP1 (c.313A>C), GCLC (TVR GAG, c.-129C>T), GCLM (c.-588C>T), NAT2 (c.282C>T, c.341T>C, c.434A>C, c.481C>T, c.590G>A, c.845A>C, c.857G>A) with severity of clinical manifestations were analyzed in 333 CF patients.

scholarly journals Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia: Risk Factors for Mortality and Microbiologic Treatment Failure

2016 ◽  
Vol 61 (1) ◽  
Author(s):  
Deanna J. Buehrle ◽  
Ryan K. Shields ◽  
Lloyd G. Clarke ◽  
Brian A. Potoski ◽  
Cornelius J. Clancy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pseudomonas Aeruginosa ◽  
Treatment Failure ◽  
Antimicrobial Therapy ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Active Therapy ◽  
Content Type ◽  
Carbapenem Resistant ◽  
Multiple Drug Resistant

ABSTRACT We reviewed 37 patients treated for bacteremia due to carbapenem-resistant (CR) Pseudomonas aeruginosa. Although 65% of isolates were multiple-drug resistant, therapeutic options were available, as all were susceptible to ≥1 antibiotic. A total of 92% of patients received active antimicrobial therapy, but only 57% received early active therapy (within 48 h). Fourteen-day mortality was 19%. Microbiologic failure occurred in 29%. The Pitt bacteremia score (P = 0.046) and delayed active therapy (P = 0.027) were predictive of death and microbiologic failure, respectively.

Stroke-Associated Acquired Stuttering

CNS Spectrums ◽  
2005 ◽  
Vol 10 (2) ◽  
pp. 94-95 ◽  
Author(s):  
Robert G. Fawcett
Keyword(s):  
Case Report ◽  
Basal Ganglia ◽  
Female Patient ◽  
Elderly Female ◽  
Ischemic Infarct ◽  
Developmental Stuttering

ABSTRACTIn this case report, the syndrome of acquired stuttering is described including its etiology, common presenting features, and differences from developmental stuttering. A case is described in an elderly female patient with sudden acquired stuttering associated with ischemic infarct near the left basal ganglia.

Sexual Dysfunction in a Patient Taking Ledipasvir/Sofosbuvir for the Treatment of Hepatitis C: A Case Report

2017 ◽  
Vol 32 (2) ◽  
pp. 231-235 ◽  
Author(s):  
Destin U. Lenz ◽  
Effie L. Crutcher ◽  
Elisa M. Greene
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sexual Dysfunction ◽  
Treatment Failure ◽  
Side Effect ◽  
Sudden Onset ◽  
Prior History

Sexual dysfunction is a bothersome side effect of several medications, though it has not yet been reported with the use of ledipasvir/sofosbuvir for the treatment of hepatitis C. However, sexual dysfunction is a potentially unrecognized side effect of ledipasvir/sofosbuvir that could result in nonadherence and treatment failure. We report a case of a 42-year-old man with a sudden onset of sexual dysfunction with the initiation of ledipasvir/sofosbuvir for the treatment of hepatitis C. The patient had no prior history or risk factors for the development of sexual dysfunction. His symptoms resolved upon discontinuation of ledipasvir/sofosbuvir after a successful 12-week course. Clinicians should be aware that sexual dysfunction is a possible side effect of ledipasvir/sofosbuvir and educate patients appropriately. Adherence should be emphasized as the risks of untreated hepatitis C virus far outweigh transient sexual dysfunction.

scholarly journals Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus

2013 ◽  
Vol 88 (5) ◽  
pp. 796-798 ◽  
Author(s):  
Mariana Ribas Zahdi ◽  
Gabriela Bestani Seidel ◽  
Vanessa Cristina Soares ◽  
Camila Fernanda Novak Pinheiro de Freitas ◽  
Fabiane Andrade Mulinari-Brenner
Keyword(s):  
Case Report ◽  
Elderly Patients ◽  
Female Patient ◽  
Oral Prednisone ◽  
Inflammatory Disorder ◽  
Parietal Region ◽  
Topical Tacrolimus ◽  
Elderly Female ◽  
Local Trauma ◽  
Progressive Enlargement

Erosive pustular dermatosis of the scalp is a rare inflammatory disorder of the scalp, affecting elderly patients after local trauma and leading to scarring or cicatricial alopecia. Case Report: An elderly female patient complained of painful pustules on the parietal region bilaterally with progressive enlargement and ulceration. A biopsy suggested erosive pustular dermatosis of the scalp and the patient was treated with prednisone 40 mg/day and 0.1% topical tacrolimus. After 10 weeks complete closure of the eroded areas was observed and a stable scarring alopecia developed.

scholarly journals Nasopharyngeal angiofibroma in an elderly female patient: A rare case report

2018 ◽  
Author(s):  
Massimo Ralli ◽  
Massimo Fusconi ◽  
Irene Visconti ◽  
Salvatore Martellucci ◽  
Marco de Vincentiis ◽  
...  
Keyword(s):  
Case Report ◽  
Female Patient ◽  
Rare Case ◽  
Nasopharyngeal Angiofibroma ◽  
Elderly Female ◽  
Rare Case Report

scholarly journals Bloodstream Infection: The Influence of Risk Factors, Etiology and Antimicrobial Therapy on Mortality Rates

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Rosana de Oliveira Santos Guimaraes ◽  
Thulio Marquez Cunha ◽  
Ana Carolina Souza Oliveira ◽  
Lucio Borges de Araujo ◽  
Reginaldo dos Santos Pedroso ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bloodstream Infection ◽  
Antimicrobial Therapy ◽  
Mortality Rates

scholarly journals Native pulmonary valve infective endocarditis with septic embolisms and an infra-annular abscess

2020 ◽  
Author(s):  
Javier Rodriguez Lega ◽  
Uxue Murgoitio Esandi ◽  
Angel Gonzalez Pinto
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Infective Endocarditis ◽  
Postoperative Period ◽  
Clinical Presentation ◽  
Pulmonary Valve ◽  
Drug Abusers ◽  
Valvular Surgery ◽  
The Right ◽  
Annular Abscess

Infective endocarditis is nowadays one of the main indications for valvular surgery. When occurring in the right chambers of the heart, the tricuspid valve is the most commonly affected. Although this disease is usually present in injecting-drug abusers or patients with other predisposing risk factors, the incidence of native pulmonary valve infective endocarditis is the least frequent. This case report presents a 51-year-old patient with no relevant medical history that was admitted to our institution with sepsis. Further studies revealed a native pulmonary valve infective endocarditis complicated with infra-annular abscess and pulmonary septic embolisms. The following describes the clinical presentation of the case, echocardiograms, the surgical procedure, and the postoperative period. To date, few cases of native pulmonary valve infective endocarditis with no previous risk factors have been reported.

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