Low-Grade Malignancy Glomus Tumor in a Setting of Multiple Glomus Tumors – Case Report

BACKGROUND: Glomus tumors are rare neoplasms accounting for less than 2% of all soft tissue tumors but multiple lesions may be seen in up to 10% of the patients. Solitary glomus tumor (GT) most frequently appears as small nodule in specific locations such as subungual region or deep dermis. However, rarely these entities have been observed in extracutaneous locations such as the gastrointestinal, cardiovascular, respiratory tracts, and other visceral organs. A small fraction of the GTs may present as tumors of uncertain malignant potential or as malignant glomus tumors. CASE PRESENTATION: We report a patient with multiple glomus tumors on the time of diagnosis, which was histologically diagnosed as an atypical glomus tumor following resection of a tumor thrombus in the left renal vein, inferior vena cava trombus with intracardial extension, and mitral valve specimen. The intramuscular lesion from the thigh was diagnosed as a glomus tumor of uncertain malignant potential. Further examinations revealed multiple lesions trough her body: kidneys, breast, heart and subcutaneous tissue. The diagnosis of glomus tumor of uncertain malignant potential versus glomus tumor with low malignant potential could be quite challenging, and the clinical course may be as a determining factor for final diagnosis. CONCLUSION: To our knowledge, this is the only known case of glomus tumor with multiple organ involvement and aggressive biological behavior at presentation.

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Glomus tumor of uncertain malignant potential

Journal of Pathology of Nepal ◽

10.3126/jpn.v1i1.4457 ◽

1970 ◽

Vol 1 (1) ◽

pp. 66-68

Author(s):

R Baral ◽

H Limbu

Keyword(s):

Glomus Tumor ◽

Subcutaneous Tissue ◽

Malignant Potential ◽

Merkel Cell ◽

Uncertain Malignant Potential ◽

Glomus Tumors ◽

Nail Bed ◽

Current Definition ◽

History Of ◽

Glomus Body

Glomus tumors closely resemble the normal glomus body and have a predilection for skin and subcutaneous tissue. Clinically, Glomus tumors are present on the nail bed and are of less than 1 cm. We report a case of a male who presented with a 3 month history of swelling in the left thumb which was mildly tender. The swelling measured 6 x 6.5 cm. On microscopy the tumor showed mild atypia with increased mitotic activity. These features, by current definition, would suggest uncertain malignant potential. Keywords: Glomus tumor; Glomangioma; Merkel cell carcinoma.DOI: 10.3126/jpn.v1i1.4457 Journal of Pathology of Nepal (2011) Vol.1, 66-68

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Glomus Tumor of Uncertain Malignant Potential: A Rare Case Report

Journal of Clinical Cases & Reports ◽

10.46619/joccr.2020.3-1054 ◽

2020 ◽

Vol 3 (1) ◽

pp. 14-17

Author(s):

Mehta Shailee ◽

◽

Dabral Ritwika ◽

Trivedi Priti ◽

◽

...

Keyword(s):

Soft Tissues ◽

Glomus Tumor ◽

Malignant Potential ◽

Uncertain Malignant Potential ◽

Current Case ◽

Glomus Tumors ◽

Large Size ◽

Rare Case Report ◽

Mitotic Figures

Glomus tumor is usually a small, benign tumor and typically occurs in the dermis or subcutis or soft tissues of the extremities and rarely in the visceral locations. Its bronchopulmonary origin is exceedingly rare clinical condition. The current case reported a 51-year-old male with dyspnea on exertion and obstructive pneumonia; he had a glomus tumor which has large size, deep location and exhibits an infiltrative margin as well as atypical mitotic figures. These characteristic suggests malignant behavior. Therefore diagnosis of glomus tumor of uncertain malignant potential was favored. Recently, the histopathological diagnostic criteria for malignant glomus tumors were defined in the WHO classification of soft tissue and bone tumors 4th edition. Here we also reviewed the literature on primary bronchopulmonary glomus tumors with special attention to the current concept of malignancy grade estimation.

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Glomus tumor: an atypical presentation

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20200611 ◽

2020 ◽

Vol 6 (2) ◽

pp. 269

Author(s):

Rajeshwari K. A. ◽

Rajagopal R.

Keyword(s):

Glomus Tumor ◽

Malignant Potential ◽

Glomus Tumour ◽

Excision Biopsy ◽

Team Approach ◽

Vascular Tumour ◽

Uncertain Malignant Potential ◽

Glomus Tumors ◽

History Of ◽

Intracytoplasmic Lumina

<div class="WordSection1"><p class="abstract">Glomus tumors are rare soft-tissue neoplasms of the neuromyoarterial glomus body, typically present in adults as small, blue-red papules or nodules of the distal extremities, with most cases involving subungual sites. The majority of glomus tumors are benign, malignant cases have been rarely reported, with such cases typically being locally invasive. 27 years old patient presented with four years history of intermittent swelling, pain in left lower leg. Biopsy of the lesion revealed lobulated vascular tumour composed of endothelial cells showing intracytoplasmic lumina and solid aggregates of tumour cells, divided by intervening fibrocollagenous septae. Glomus tumour of uncertain malignant potential was diagnosed after excision biopsy. Multispeciality team approach was done for complete cure of the condition.</p></div>

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Glomangioma of Uncertain Malignant Potential: A Case Report

Case Reports in Orthopedics ◽

10.1155/2020/4237076 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Meghan McCullough ◽

Bonnie Balzer ◽

Stuart H. Kuschner

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Glomus Tumor ◽

Malignant Potential ◽

Benign Tumors ◽

Uncertain Malignant Potential ◽

Glomus Tumors ◽

Soft Tissue Masses ◽

High Index Of Suspicion ◽

And Behavior

Glomus tumors are rare benign tumors which commonly affect the hand but are seldom seen extradigitally. Less commonly seen is the glomangioma, a variant of benign glomus tumor, and even rarer is the glomangiosarcoma, a malignant variant. Determining malignancy can be difficult and an intermediate diagnosis, glomus tumor of uncertain malignant potential, has been proposed. We present a case of a 56-year-old male with a recurrent forearm mass diagnosed as a glomangioma of uncertain malignant potential. Although the characteristics and behavior of malignant cases are still incompletely understood, it is important that a high index of suspicion be maintained when approaching these tumors, especially when large or recurrent. Glomangiomas should be included in the differential diagnosis when evaluating soft tissue masses in the forearm and should be evaluated for malignant features.

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