SUBUNGUAL GLOMUS TUMOUR: THE ENIGMATIC CAUSE OF CHRONIC PAINFUL FINGER PULP - A CASE REPORT

Glomus tumour, also referred to as Barré–Masson syndrome is an enigmatic, rare, painful tumour that is that represents a proliferation of the normal capsular-neural glomus apparatus. These are rare hamartomas that arise from the traditional glomus apparatus, located in subcutaneous tissue These are benign soft tissue neoplasms presenting usually within the second to fourth decade of life, originating from the glomus body. It accounts for 1-5% of all upper limb soft tissue tumors . It's a component of the dermis layer of the [1] skin, involved in thermoregulation. It structurally consists of an arterio-venous shunt which is surrounded by a connective tissue capsule and is found in increased amounts in the ngers and toes.

Metastatic Malignant Gastric Glomus Tumour: Multidisciplinary Diagnosis & Treatment of a Rare Clinical Entity

Glomus tumours are uncommon neoplasms that are usually benign, solitary and most often found in the skin and soft tissue of distal extremities. Primary gastric glomus tumors are rare, but well described. Fewer than 15 cases of gastric glomus tumour have been reported to have malignant behaviour with distant metastases. Although surgical resection is effective if feasible, recurrence can occur and there is a paucity of evidence on medical treatment options. Here we present the case of a 69-year-old male with a gastric glomus tumour with metastases to abdominal viscera requiring multidisciplinary care for diagnosis, surgical resection, and multiple lines of systemic/radiation therapy guided by available evidence. Genomic analysis revealed a NOTCH2 rearrangement, described in only two prior works and highlighting future possibilities for targeted therapy.

Glomangiomyoma of Uncertain Malignant Potential in the Urinary Bladder: A Case Report

Glomus tumour typically occurs in subcutaneous tissue but rarely in the visceral organs. Most glomus tumours are benign but few atypical glomus tumours have been reported. Herein, we report a case of a 44-year-old male who presented with hematuria. Transurethral resection of bladder tumour was done. Microscopic examination showed nests and sheets of tumor around the blood vessels. Spindle cells resembling smooth muscle were also observed. An increase in mitosis was observed. These tumour cells show diffuse and strong cytoplasmic positivity for smooth muscle actin and negative for Pancytokeratin, Desmin, Synaptophysin, Chromogranin, S100, and Cluster of Differentiation 34. Ki-67 index was approximately 5%. To our knowledge, this is the first report of Glomangiomyoma of uncertain malignant potential in the urinary bladder which is considered as an unusual variant of atypical glomus tumor. This case emphasizes the importance of broad differential diagnosis which has to be considered in the urinary bladder mass.

Numerical assessment of natural respiration and particles deposition in the computed tomography scan airway with a glomus tumour

The human respiratory tract has a complex airflow pattern. If any obstruction is present in the airways, it will change the airflow pattern and deposit particles inside the airways. This is the concern of breath quality (inspired air), and it is decreasing due to the unplanned production of material goods. This is a primary cause of respiratory illness (asthma, cancer, etc.). Therefore, it is important to identify the flow characteristics in the human airways and airways with a glomus tumour with particle deposition. A numerical diagnosis is presented with an asymmetric unsteady-state light breathing condition (10 l/min). An in vitro human respiratory tract model has been reconstructed using computed tomography scan techniques and an artificial glomus tumour developed 2 cm above a carina on the posterior wall of the trachea. The transient flow characteristics are numerically simulated with a realizable (low Reynolds number) k–ɛ turbulence model. The flow disturbance is captured around the tumour, which influenced the upstream and downstream of the flow. The flow velocity pattern, wall shear stress and probable area of inflammation (hotspot) due to suspended particle deposition are determined, which may assist doctors more effectively in aerosol therapy and prosthetics of human airways illness.

Extradigital glomangiomyoma of the forearm mimicking peripheral nerve sheath tumour and thrombosed varicose vein

Extradigital glomus tumour is uncommon, little-known outside of its subungual location, and may present without its classic triad of tenderness, cold sensitivity and paroxysmal pain. Imaging is non-specific and diagnosis is often delayed, sometimes for years, leading to unnecessary morbidity. Surgical excision is the treatment of choice, although technique depends on case specifics. Histological subtypes depend on the relative prominence of glomus cells, vascular structures and smooth muscle. The vast majority of glomus tumours are benign. We highlight the importance of considering extradigital glomus tumours when generating differential diagnoses of an atypical painful lesion in a variety of clinical specialties.

Glomus Tumour of the Lip Mimicking Squamous Cell Carcinoma - A Rare Case Report

Glomus tumour is a rare soft tissue neoplasm arising from glomus body, which is in an arteriovenous anastomosis located particularly in the dermis. This tumour occurs most commonly in hands and feet, and is seldom found in other sites. The purpose of this report is to describe an unusual case of glomus tumour in the lip. A 17-year-old woman with a firm, painless and ulcerated lump in her lower lip was admitted to our clinic. Excisional biopsy was performed, and histopathological analysis revealed the lesion to be a subtype of glomus tumour called as a glomangioma. Most glomus tumours are benign and may be treated by simple surgical excision. A typical glomus tumour of the hand is readily diagnosed, but it may occur anywhere such as oral cavity or internal organs, and its small size and atypical anatomical site presents a diagnostic dilemma. Therefore, a glomus tumour should be considered in the differential diagnosis of mass in the lips. Glomus tumour was first mentioned by Wood as a painful subcutaneous tubercle.1,2 It is classified as a pericystic (perivascular) tumour by the World Health Organization. Perivascular tumours are most frequently noticed in the superficial soft tissues at any age and are not seen commonly in the oral cavity. Synonyms for glomus tumour include glomangioma, glomangiomyoma, glomangiomatosis, glomangiopericytoma, and Popoff tumour. 3 Glomus tumour is presumed to arise from glomus body, which may be defined as a special arteriovenous anastomosis located in the stratum reticular of the dermis. It is lined by smooth muscle and glomus cells.4 The glomus body has been implicated in playing a role in thermal regulation.5 It is ubiquitous but digits are the most common sites. Clinically, the lesion is usually seen as a painful nodule located in the nail bed of the distal phalanges. Occurrence in the oral cavity is particularly rare. In this article, we present a rare case of glomus tumour located in the lower lip mimicking a malignant tumour.