scholarly journals Construction and expression of a recombinant eukaryotic expression plasmid containing the preS1-preS2-S genes of hepatitis B virus and the granulocyte-macrophage colony stimulating factor gene: A study of its immunomodulatory effects

2012 ◽  
Vol 1 (2) ◽  
pp. 251-256
Author(s):  
JUN-YUAN GONG ◽  
XIN LIU ◽  
YAN DONG ◽  
TIAN-HONG ZHOU ◽  
JUN-WU LI
Keyword(s):  
Eukaryotic Expression ◽  
Eukaryotic Expression Plasmid ◽  
Immunomodulatory Effects ◽  
Expression Plasmid ◽  
Factor Gene ◽  
B Virus ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor ◽  
S Genes

scholarly journals Testing of Experimental Compounds in a Relapse Model of Tuberculosis Using Granulocyte-Macrophage Colony-Stimulating Factor Gene-Disrupted Mice

2008 ◽  
Vol 53 (1) ◽  
pp. 306-308 ◽  
Author(s):  
Lisa K. Woolhiser ◽  
Donald R. Hoff ◽  
Karen S. Marietta ◽  
Ian M. Orme ◽  
Anne J. Lenaerts
Keyword(s):  
Subsequent Treatment ◽  
In Vivo Model ◽  
Disease Relapse ◽  
Colony Stimulating Factor ◽  
Factor Gene ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor ◽  
Number Of Bacteria

ABSTRACT This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis. The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.

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