scholarly journals Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice

2017 ◽  
Vol 39 (6) ◽  
pp. 1555-1563 ◽  
Author(s):  
Ya-Jun Ren ◽  
Lei Zhang ◽  
Tao Bai ◽  
Hong-Lu Yu ◽  
Ying Li ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Lamina Propria ◽  
Mononuclear Phagocytes ◽  
Visceral Hypersensitivity ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Irritable Bowel ◽  
Post Infectious

scholarly journals Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls

2011 ◽  
Vol 301 (5) ◽  
pp. G919-G928 ◽  
Author(s):  
Archana S. Rao ◽  
Michael Camilleri ◽  
Deborah J. Eckert ◽  
Irene Busciglio ◽  
Duane D. Burton ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Diseases ◽  
Oral Solution ◽  
Mucosal Barrier ◽  
Healthy Controls ◽  
Barrier Dysfunction ◽  
Capsule Formulation ◽  
Mucosal Permeability ◽  
Irritable Bowel

Mucosal barrier dysfunction contributes to gastrointestinal diseases. Our aims were to validate urine sugar excretion as an in vivo test of small bowel (SB) and colonic permeability and to compare permeability in patients with irritable bowel syndrome-diarrhea (IBS-D) to positive and negative controls. Oral lactulose (L) and mannitol (M) were administered with 99mTc-oral solution, 111In-oral delayed-release capsule, or directly into the ascending colon (only in healthy controls). We compared L and M excretion in urine collections at specific times in 12 patients with IBS-D, 12 healthy controls, and 10 patients with inactive or treated ulcerative or microscopic colitis (UC/MC). Sugars were measured by high-performance liquid chromatography-tandem mass spectrometry. Primary endpoints were cumulative 0–2-h, 2–8-h, and 8–24-h urinary sugars. Radioisotopes in the colon at 2 h and 8 h were measured by scintigraphy. Kruskal-Wallis and Wilcoxon tests were used to assess the overall and pairwise associations, respectively, between group and urinary sugars. The liquid in the colon at 2 h and 8 h was as follows: health, 62 ± 9% and 89 ± 3%; IBS-D, 56 ± 11% and 90 ± 3%; and UC/MC, 35 ± 8% and 78 ± 6%, respectively. Liquid formulation was associated with higher M excretion compared with capsule formulation at 0–2 h (health P = 0.049; IBS-D P < 0.001) but not during 8–24 h. UC/MC was associated with increased urine L and M excretion compared with health (but not to IBS-D) at 8–24 h, not at 0–2 h. There were significant differences between IBS-D and health in urine M excretion at 0–2 h and 2–8 h and L excretion at 8–24 h. Urine sugars at 0–2 h and 8–24 h reflect SB and colonic permeability, respectively. IBS-D is associated with increased SB and colonic mucosal permeability.

scholarly journals Giardiasis and post-infectious bowel syndrome

2021 ◽  
pp. 178-187
Author(s):  
A. A. Belova ◽  
M. D. Shestakova ◽  
A. I. Khavkin
Keyword(s):  
Immune Response ◽  
Irritable Bowel Syndrome ◽  
Gastrointestinal Tract ◽  
Species Composition ◽  
Intestinal Microbiota ◽  
Mucosal Barrier ◽  
Irritable Bowel ◽  
The Moment ◽  
High Level ◽  
Post Infectious

Post-infectious irritable bowel syndrome — one of the most frequent conditions diagnosed in pediatric gastroenterological practice. According to numerous research parisitosis contributes to the chronology of gastrointestinal tract pathology. it is known that the infection Lamblia intestinalis can increase the risk of developing post-infectious IBS, changing species composition and diversity of the intestinal microbiota, modulating metabolism of the host, the nature of the immune response and adversely affecting the mucosal barrier and the motility of the digestive tract. Importantly, the prevalence of giardiasis in patients with symptoms of IBS and dyspepsia at the moment, it remains at a high level. Further research into the pathogenesis of Lamblia intestinalis infection in patients with IBS will be of great importance in medicine.

scholarly journals Unique strain of Bifidobacterium longum and its efficacy in irritable bowel syndrome

2021 ◽  
pp. 144-150
Author(s):  
E. Yu. Plotnikova
Keyword(s):  
Irritable Bowel Syndrome ◽  
Barrier Function ◽  
Adult Population ◽  
Bifidobacterium Longum ◽  
Intestinal Flora ◽  
Visceral Hypersensitivity ◽  
Mucosal Barrier ◽  
Abdominal Symptoms ◽  
Mucosal Barrier Function ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal disorders affecting between 5 and 15% of the general adult population worldwide. Over the course of many years altered intestinal motility, visceral hypersensitivity, immune changes and, as it has recently been found, impaired epithelial barrier function were meant to explain the origin of symptoms in the IBS. We have come to realize now that the IBS warrants serious clinical and scientific study. Not that long ago, the connections between the gut and the brain have been expanded to include a new entrant, the microbiota, resulting in the creation of a new concept of a microbiota-gut-brain axis.Microbiota is a risk factor for the irritable bowel syndrome. Probiotics are defined as live microorganisms, which can alter the intestinal flora and regulate intestinal functions such as reduction of visceral hypersensitivity, improvement of mucosal barrier function, modulate immune responses and chronic inflammation, affect the central nervous system, gastrointestinal motility, etc. The correctness of this approach is confirmed by several studies of the probiotic Bifidobacterium longum subsp. longum 35624, which is widely used in the treatment of symptoms of irritable bowel syndrome. The dietary supplement Bifidobacterium longum subsp. longum 35624 contains 1 × 109 colony-forming units, which provides a clinically effective level of these beneficial bacteria. Bifidobacterium longum subsp. longum 35624 also reduces inflammation in the gastrointestinal tract and has positive results in reducing abdominal symptoms (e.g. abdominal pain / discomfort and bloating) associated with the irritable bowel syndrome and other conditions. 

Modern possibilities for correction of visceral hypersensitivity in patients with irritable bowel syndrome

2020 ◽  
Vol 0 (2) ◽  
pp. 37-44
Author(s):  
І. М. Skrypnyk ◽  
I. H. Kryvoruchko ◽  
O. F. Gopko ◽  
N. P. Prykhodko
Keyword(s):  
Irritable Bowel Syndrome ◽  
Visceral Hypersensitivity ◽  
Irritable Bowel

scholarly journals Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

2021 ◽  
Vol 14 ◽  
pp. 175628482199358
Author(s):  
Nikita Hanning ◽  
Adam L. Edwinson ◽  
Hannah Ceuleers ◽  
Stephanie A. Peters ◽  
Joris G. De Man ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Barrier Function ◽  
Significant Proportion ◽  
Healthy Controls ◽  
Barrier Dysfunction ◽  
Irritable Bowel

Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes of IBS. Our aim is to review studies evaluating barrier dysfunction in adults and children with IBS, as well as to link those changes with IBS symptomatology and quality of life. Methods: A comprehensive and systematic review of multiple databases was performed up to March 2020 to identify studies comparing intestinal permeability in IBS patients with healthy controls. Both in vivo and in vitro studies were considered. Results: We identified 66 studies, of which 27 used intestinal probes to quantify barrier function. The prevalence of barrier dysfunction differed between PI-IBS (17–50%), IBS-D (37–62%) and IBS-C (4–25%). At a group level, permeability was increased compared with healthy controls in IBS-D (9/13 studies) and PI-IBS (4/4 studies), but only a minority of IBS-C (2/7 studies) and not in the only IBS-M study. All four studies in children with IBS demonstrated loss of barrier function. A heterogeneous set of tight junction genes were found to be altered in small and large intestines of adults with IBS, but these have not been evaluated in children. Positive associations were identified between barrier dysfunction and bowel disturbances (6/9 studies), abdominal pain (9/13 studies), overall symptom severity (1/6 studies), depression and anxiety (1/1 study) and quality of life (1/4 studies). Fecal slurry or supernatants of IBS patients were found to induce barrier disruption in animal models (5/6 studies). Conclusions: Barrier dysfunction is present in a significant proportion of adult and all pediatric IBS studies, especially in the IBS-D and PI-IBS subtype. The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function.

NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64208-64214 ◽  
Author(s):  
Shenglan Yang ◽  
Danfang Deng ◽  
Yingying Luo ◽  
Yanran Wu ◽  
Rui Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Irritable Bowel Syndrome ◽  
Hydrogen Sulfide ◽  
Murine Model ◽  
Irritable Bowel ◽  
And Oxidative Stress ◽  
Post Infectious

In this study, the alleviating role of hydrogen sulfide (H2S) was investigated in a Post-Infectious Irritable Bowel Syndrome (PI-IBS) murine model and Caco-2 cells.

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