Rhein inhibits TPA-induced activator protein-1 activation and cell transformation by blocking the JNK-dependent pathway

2003 ◽  
Author(s):  
Shigang Lin ◽  
Jian-Jian Li ◽  
Makoto Fujii ◽  
De-Xing Hou
Keyword(s):  
Cell Transformation ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Dependent Pathway

Evodiamine Inhibits 12-O -Tetradecanoylphorbol-13-acetate-induced Activator Protein 1 Transactivation and Cell Transformation in Human Hepatocytes

2011 ◽  
Vol 25 (7) ◽  
pp. 1018-1023 ◽  
Author(s):  
De-Cheng Chao ◽  
Li-Jen Lin ◽  
Chien-Yun Hsiang ◽  
Chia-Cheng Li ◽  
Hsin-Yi Lo ◽  
...  
Keyword(s):  
Cell Transformation ◽  
Human Hepatocytes ◽  
Activator Protein 1 ◽  
Activator Protein

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription

2001 ◽  
Vol 268 (6) ◽  
pp. 1802-1810
Author(s):  
Danielle Naville ◽  
Estelle Bordet ◽  
Marie-Claude Berthelon ◽  
Philippe Durand ◽  
Martine Begeot
Keyword(s):  
Angiotensin Ii ◽  
Gene Transcription ◽  
Receptor Gene ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Stimulation Of
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