ONO-4007, a synthetic lipid A analog, induces Th1-type immune response in tumor eradication and restores nitric oxide production by peritoneal macrophages

2003 ◽  
Author(s):  
Kazuhiro Matsushita ◽  
Yasuhiro Kuramitsu ◽  
Yoichi Ohiro ◽  
Ichizo Kobayashi ◽  
Tae Watanabe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Immune Response ◽  
Lipid A ◽  
Peritoneal Macrophages ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Tumor Eradication

Evidence for Endogenous C1q Modulates TNF-α Receptor Synthesis and Autocrine Binding of TNF-α Associated with Lipid A Activation of Murine Macrophages for Nitric Oxide Production

1996 ◽  
Vol 170 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Hong Jiang ◽  
John A. Rummage ◽  
Charles A. Stewart ◽  
Mary J. Herriott ◽  
Irina Kolosova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lipid A ◽  
Nitric Oxide Production ◽  
Murine Macrophages ◽  
Oxide Production ◽  
Tnf Α

scholarly journals Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase.

1995 ◽  
Vol 181 (1) ◽  
pp. 63-70 ◽  
Author(s):  
N K Worrall ◽  
W D Lazenby ◽  
T P Misko ◽  
T S Lin ◽  
C P Rodi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Immune Response ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Biologically Active ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

The role of nitric oxide in the immune response to allogeneic tissue was explored in an in vivo cardiac transplant model in the rat. Nitric oxide production during organ rejection was demonstrated by elevations in systemic serum nitrite/nitrate levels and by electron paramagnetic resonance spectroscopy. Messenger RNA for the inducible nitric oxide synthase enzyme was detected in the rejecting allografted heart, but not in the nonrejecting isografted heart. The enzyme was demonstrated to be biologically active by the in vitro conversion of L-arginine to L-citrulline and was immunohistochemically localized to the infiltrating inflammatory cells. Treatment with aminoguanidine, a preferential inhibitor of the inducible nitric oxide synthase isoform, prevented the increased nitric oxide production in the transplanted organ and significantly attenuated the pathogenesis of acute rejection. Aminoguanidine treatment prolonged graft survival, improved graft contractile function, and significantly reduced the histologic grade of rejection. These results suggest an important role for nitric oxide in mediating the immune response to allogeneic tissue. Inhibition of inducible nitric oxide synthase may provide a novel therapeutic modality in the management of acute transplant rejection and of other immune-mediated processes.

scholarly journals Participation of simultaneously produced prostaglandin E2 in nitric oxide production in TPA—stimulated rat peritoneal macrophages

1998 ◽  
Vol 76 ◽  
pp. 105
Author(s):  
Gaku Ichinowatari ◽  
Masateru Yamada ◽  
Atsuo Tanimoto ◽  
Hiroshi Yaginuma ◽  
Suetsugu Mue ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Prostaglandin E2 ◽  
Peritoneal Macrophages ◽  
Nitric Oxide Production ◽  
Oxide Production

scholarly journals miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

Immunology ◽  
2011 ◽  
Vol 135 (1) ◽  
pp. 73-88 ◽  
Author(s):  
Ana L. Cardoso ◽  
Joana R. Guedes ◽  
Luís Pereira de Almeida ◽  
Maria C. Pedroso de Lima
Keyword(s):  
Nitric Oxide ◽  
Immune Response ◽  
Nitric Oxide Production ◽  
Oxide Production

Low doses of monocrotaline in rats cause diminished bone marrow cellularity and compromised nitric oxide production by peritoneal macrophages

2009 ◽  
Vol 6 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Isis M. Hueza ◽  
Julia C. Benassi ◽  
Paulo C. F. Raspantini ◽  
Leonila E. R. Raspantini ◽  
Lilian R. M. Sa´ ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bone Marrow ◽  
Peritoneal Macrophages ◽  
Nitric Oxide Production ◽  
Low Doses ◽  
Bone Marrow Cellularity ◽  
Oxide Production ◽  
Marrow Cellularity

Nitric oxide production and oxy-LDL metabolism in rat peritoneal macrophages

1994 ◽  
Vol 109 (1-2) ◽  
pp. 114
Author(s):  
J. Dulak ◽  
I. Wybran´ska ◽  
E. Baczyn´ska ◽  
M. Pawelec ◽  
A. Dembin´ska-Kiec´
Keyword(s):  
Nitric Oxide ◽  
Peritoneal Macrophages ◽  
Nitric Oxide Production ◽  
Oxide Production

scholarly journals A Dirofilaria immitis Polyprotein Up-Regulates Nitric Oxide Production

2002 ◽  
Vol 70 (9) ◽  
pp. 5283-5286 ◽  
Author(s):  
Hiroyuki Tezuka ◽  
Shinjiro Imai ◽  
Setsuko Tsukidate ◽  
Koichiro Fujita
Keyword(s):  
Nitric Oxide ◽  
Dirofilaria Immitis ◽  
Peritoneal Macrophages ◽  
No Production ◽  
Nitric Oxide Production ◽  
Wild Type ◽  
Murine Macrophages ◽  
Oxide Production

ABSTRACT We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40−/−, mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.

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