In vitro modulation of MCF-7 breast cancer cell growth by myoepithelial cells

1996 ◽  
Author(s):  
D Bani ◽  
L Magnelli ◽  
O Gallo
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Myoepithelial Cells ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Mcf 7

Fucoidan Inhibited 4T1 Mouse Breast Cancer Cell Growth In Vivo and In Vitro Via Downregulation of Wnt/β-Catenin Signaling

2013 ◽  
Vol 65 (3) ◽  
pp. 460-468 ◽  
Author(s):  
Meilan Xue ◽  
Yinlin Ge ◽  
Jinyu Zhang ◽  
Yongchao Liu ◽  
Qing Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Mouse Breast Cancer

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

2009 ◽  
Vol 120 (1) ◽  
pp. 253-260 ◽  
Author(s):  
Ramon C. Sun ◽  
Mitali Fadia ◽  
Jane E. Dahlstrom ◽  
Christopher R. Parish ◽  
Philip G. Board ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Metastatic Breast ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells

2012 ◽  
Vol 12 (1) ◽  
pp. 1233-1238 ◽  
Author(s):  
YING WANG ◽  
LEQIU WANG ◽  
CHANGHAO YIN ◽  
BAIZHU AN ◽  
YANKUN HAO ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Arsenic Trioxide ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Mcf 7

scholarly journals In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors

Oncotarget ◽  
2016 ◽  
Vol 7 (8) ◽  
pp. 9250-9270 ◽  
Author(s):  
Monica Benvenuto ◽  
Laura Masuelli ◽  
Enrico De Smaele ◽  
Massimo Fantini ◽  
Rosanna Mattera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Marina Makrecka-Kuka ◽  
Pavels Dimitrijevs ◽  
Ilona Domracheva ◽  
Kristaps Jaudzems ◽  
Maija Dambrova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Drug Candidates ◽  
Breast Cancer Cell Growth ◽  
Cell Growth Suppression ◽  
Potent Drug

AbstractThe development of targeted drugs for the treatment of cancer remains an unmet medical need. This study was designed to investigate the mechanism underlying breast cancer cell growth suppression caused by fused isoselenazolium salts. The ability to suppress the proliferation of malignant and normal cells in vitro as well as the effect on NAD homeostasis (NAD+, NADH, and NMN levels), NAMPT inhibition and mitochondrial functionality were studied. The interactions of positively charged isoselenazolium salts with the negatively charged mitochondrial membrane model were assessed. Depending on the molecular structure, fused isoselenazolium salts display nanomolar to high micromolar cytotoxicities against MCF-7 and 4T1 breast tumor cell lines. The studied compounds altered NMN, NAD+, and NADH levels and the NAD+/NADH ratio. Mitochondrial functionality experiments showed that fused isoselenazolium salts inhibit pyruvate-dependent respiration but do not directly affect complex I of the electron transfer system. Moreover, the tested compounds induce an immediate dramatic increase in the production of reactive oxygen species. In addition, the isoselenazolothiazolium derivative selectively binds to cardiolipin in a liposomal model. Isoselenazolium salts may be a promising platform for the development of potent drug candidates for anticancer therapy that impact mitochondrial pyruvate-dependent metabolism in breast cancer cells.

Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro

1998 ◽  
Vol 130 (1-2) ◽  
pp. 143-152 ◽  
Author(s):  
Laura Fioravanti ◽  
Vera Cappelletti ◽  
Patrizia Miodini ◽  
Enrico Ronchi ◽  
Moreno Brivio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Mechanism Of Action ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth
Sign in / Sign up

Export Citation Format

Share Document