scholarly journals Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node)

2021 ◽  
Vol 7 (3) ◽  
pp. 73-81
Author(s):  
Pavel A. Galenko-Yaroshevsky ◽  
Anatoly A. Nechepurenko ◽  
Tatiana G. Pokrovskaya ◽  
Nikolai L. Shimonovsky ◽  
Alexander S. Dukhanin ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Medulla Oblongata ◽  
High Frequency ◽  
Sinoatrial Node ◽  
Heart Rhythm ◽  
Cardiac Pacing ◽  
High Frequency Electromagnetic Field ◽  
Reflex Stimulation ◽  
Reflexogenic Zone ◽  
Stimulation Of

Introduction: Cardiac pacing is indicated for sick sinus syndrome. It is performed with a pacemaker via electrodes implanted in the heart. This technique has several disadvantages. The search for alternative methods of cardiac pacing is underway. One of them is control of heart rhythm through stimulation of the tragus. Objective: To perform the reflex stimulation of the sinoatrial node and to study the influence of the SS-68 substance on it. Materials and methods: Two electrodes were fixed in the reflexogenic zone of rabbits’ auricles, volleys of electrical impulses from an electrical stimulator were applied to the electrodes, and the synchronization range of volley frequency and cardiac contractions was recorded. This range was re-recorded again after injecting the SS-68 substance (2-phenyl-1-(3-pyrrolidine-1-cyclopropyl)-1H-indole hydrochloride) intravenously at a dose of 50 µg/kg. In other experiments on frogs in a high-frequency electromagnetic field, the process of excitation of the area of the medulla oblongata associated with the heart rhythm was visualized. After the application of SS-68 (50 μM) to the surface of this zone, the process of its excitation was recorded. Results and discussion: Stimulation of the auricular reflexogenic zone of rabbits produced a synchronization of volley frequency and heart rate in the range from 173.5 ± 2.0 to 214.0 ± 1.8 per minute. SS-68 extended this range from 168.2 ± 1.9 to 219.4 ± 1.5 per minute. In the frog’s medulla oblongata, an area synchronous to the heart rhythm glowed in the high-frequency electromagnetic field. SS-68 increased the area of glow by 131.0%. Conclusion: The substance SS-68 increases the frequency range of heart rhythm control by activating reflex stimulation of the sinoatrial node. The main point of application of SS-68 is the medulla oblongata. Glow in the high-frequency electromagnetic field reflects the process of neuron excitation. The increase in the glow zone under the influence of SS-68 indicates synchronously excited neurons, which leads to the assimilation of the central heart rhythm generation by the sinoatrial node.

scholarly journals ЗМІНА ЕЛЕКТРИЧНИХ ВЛАСТИВОСТЕЙ НАСІННЯ ПІД ВПЛИВОМ ВИСОКОЧАСТОТНОГО ЕЛЕКТРОМАГНІТНОГО ОПРОМІНЕННЯ

2014 ◽  
pp. 151-155
Author(s):  
О. М. Петровський
Keyword(s):  
Electromagnetic Field ◽  
High Frequency ◽  
Electric Properties ◽  
Electric Resistance ◽  
Active Resistance ◽  
Exchange Processes ◽  
High Frequency Electromagnetic Field ◽  
Stimulation Of

Розглянуті питання передпосівної стимуляції на-сіння високочастотним електромагнітним полем.Запропоновано спосіб опромінення насіння і визна-чення його електричних характеристик. На основібудови клітин визначені електричні властивості біо-логічної тканини, з якої складається насіння. Пока-зана зміна складових активного опору в залежностівід частоти струму. Експериментально доведено,що еквівалентну електричну схему неможливо звес-ти до простих випадків з’єднання опорів і ємностей,а саме насіння не можна вважати нейтральнимдіелектриком. Розроблена методика оцінки інтенси-вності обмінних процесів залежно від електричногоопору насіння. The questions of stimulation of seed before sowing are considered by the high-frequency electromagnetic field considered. The method of irradiation of seed and determination of him is offered electric descriptions. On the basis of structure of cages electric properties of biological fabric which seed consist of are certain. The change of constituents of active resistance is shown depending on frequency of current. It is experimentally proved that it is impossible to erect an equivalent electric chart to the simple cases of connection of resistances and capacities, namely seed can not be considered a neutral dielectric. The method of estimation of intensity of exchange processes  is developed depending on electric resistance of seed.

scholarly journals The method of determining the number of excited efferent cardiac fibers in the vagus nerve of a cat

2019 ◽  
Vol 6 (5) ◽  
pp. 228-230
Author(s):  
Minenko IA ◽  
Pokrovsky VM ◽  
Tarasov DG ◽  
Nechepurenko AA ◽  
Pokhotko AG ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Vagus Nerve ◽  
High Frequency ◽  
Thyroid Cartilage ◽  
Glass Tube ◽  
Heart Rhythm ◽  
Video Camera ◽  
Cervical Region ◽  
High Frequency Electromagnetic Field ◽  
Cardiac Fibers

Objective: Developing method of determination the number of excited efferent cardiac fibers in the cervical region of the vagus nerve of a cat by estimating the area of the glow in the high-frequency electromagnetic field inside the nerve. Materials and methods: The observations were carried out on cats in conditions of superficial (27 cats) or deep anesthesia (13 cats out of 27) and irritation of the vagus nerve with electrical impulses (14 cats out of 27). The right vagus nerve on cat’s neck was allocated and cut at the level of the lower edge of thyroid cartilage. The central end was inserted into a glass tube. Before the cut end in the transverse plane, a scanner from the unit, which creates a high-frequency electromagnetic field was installed. The glow from the scanner were recorded by a video camera through the microscope. At the same time, the ECG was recorded. Based on the ECG signal, for the processing we took the centers of glow related to the heart rhythm. The results were processed in the "STATISTIKA 6.0" program. Results: In superficial anesthesia, the number of excitable efferent fibers was 350 or 70.0% of the available ones. In case of deep anesthesia, 193 or 38.6% accordingly. In case of nerve stimulation above the transection site all available efferent fibers have been excitable. Conclusions: Results of this work suggest a way to identify and determine the number of excitable efferent cardiac fibers in the vagus nerve and their localization on the cross section of the central end of the nerve from the area of luminescence in high-frequency electric field.

scholarly journals PRESOWING STIMULATION OF ECHINACEA AND VALERIAN SEEDS WITH ULTRA-HIGH FREQUENCY ELECTROMAGNETIC FIELD

2020 ◽  
Vol 20 (1) ◽  
pp. 145-148
Author(s):  
N.V. Solovievа ◽  
O. M. Petrovskiy ◽  
O.E. Ilyash ◽  
N.I. Kolesnikova ◽  
T. Yu. Kuznetsova ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
High Frequency ◽  
Cell Membranes ◽  
Theoretical Calculations ◽  
Physiological State ◽  
Protein Structures ◽  
Experimental Studies ◽  
Metabolic Processes ◽  
High Frequency Electromagnetic Field ◽  
Stimulation Of

The article presents the results obtained by testing the previously proposed physical and mathematical model of the temperature distribution in the layer of poured seeds when irradiated with a high-frequency electromagnetic field. It has been proven that temperature is one of the factors influencing the consequences of pre-sowing seed treatment. We have found out that, along with heating, other physical processes occur in the seed structure at the level of cell membranes and membrane transport of substances. The transformation of protein structures, the polarization of cell membranes, and the intensification of metabolic processes under the influence of irradiation can lead to changes in the electrical properties of seeds and, as a consequence, can impact on the physiological state, germinability and growth energy of plants. The result of the seed exposure to high-frequency electromagnetic field depends on the electrical characteristics of the seeds. We have developed a technology for the pre-sowing treatment of Echinacea and Valerian seeds in order to obtain more ecologically pure raw materials for pharmacological industry. The study has demonstrated positive thermal and oscillation effects produced by the electromagnetic field on the structural elements of seeds. Based on the method of presowing stimulation of the seeds with a high-frequency electromagnetic field, the optimal modes for irradiation of Echinacea and Valerian seeds have been elaborated. It has been established that boosting the overall resistance of biological tissue, an increase in the polarization of cell membranes indicates an enhancement of metabolic processes and, as a result, stimulates the process of seed germination and rapid vegetation in the early stages of plant development. Theoretical calculations and experimental studies have evidenced positive results doe to implementation of the described technology.

scholarly journals VISUALIZATION OF THE EXCITATION PROCESS IN THE FROG'S NERVES

2018 ◽  
Vol 25 (4) ◽  
pp. 51-54
Author(s):  
N. V. KORNILOVA ◽  
V. G. ABUSHKEVICH ◽  
A. N. ARDELYAN ◽  
Yu. Yu. PEROVA ◽  
A. G. POKHOT'KO
Keyword(s):  
Electromagnetic Field ◽  
Sciatic Nerve ◽  
High Frequency ◽  
Heart Rhythm ◽  
Excitation Process ◽  
Standard Lead ◽  
High Frequency Electromagnetic Field ◽  
V Wave ◽  
The Right ◽  
Electrical Impulses

Aim.Visualization of the excitation process in the frog's nerves.Materials and methods. Observations were carried out on 30 immobilized frogs. Vagosympathetic trunks and sciatic nerve were  allocated from the frogs. Ligatures were placed on the right  vagosympathetic trunk crossing it. A scanner of the gas discharge  visualization camera of the CELSY device, which created a high- frequency electromagnetic field (1024 Hz), was installed above the  nerves. The scanner with a highly sensitive camera shot a 60-second video (the frequency of frame-by-frame shooting to 1000 frames per second), during which the edge luminescence (Kirlian effect) and the  glow spots were recorded inside the nerve. The  electrocardiogram (ECG) was synchronously recorded in the I  standard lead. The processing of the obtained results was carried out according to the area of the glow spot, the area of the highest luminescence brightness, the direction of the movement of  the foci of the luminescence, and the linear velocity of the movement of the glow foci.Results.Foci of the internal luminescence appeared only in the high-frequency electromagnetic field in the sciatic nerve of the frog  when the nerve was stimulated by electrical impulses, which resulted in the contraction of the frog's foot. Glow foci of the brain  synchronous to the heart rhythm and preceding the tooth of the V- wave on the frog’s ECG were observed at the central end of the cut  of the frog’s vagosympathetic trunk. Conclusion.Visualized foci of luminescence in the nerve reflect the neural activity.

scholarly journals Effect of high-frequency electromagnetic field on microstructure of mold flux

2020 ◽  
Vol 39 (1) ◽  
pp. 368-376
Author(s):  
Xingjuan Wang ◽  
Hebin Jin ◽  
Liguang Zhu ◽  
Ran Liu ◽  
Tushun Song
Keyword(s):  
Electromagnetic Field ◽  
High Frequency ◽  
Mold Flux ◽  
Film Structure ◽  
Glass Layer ◽  
Slag Film ◽  
Flux Flow ◽  
Layer Form ◽  
Finite Element Software ◽  
High Frequency Electromagnetic Field

AbstractSoft-contact of molten steel can be achieved by applying a high-frequency electromagnetic field above the mold of continuous casting, which can effectively eliminate surface defects and achieve billets with no cracks and no oscillation marks. It also has some influence on the mold flux. In this study, the effect of a high-frequency electromagnetic field (20 kHz) on a mold flux flow field was simulated using a finite element software, and the slag film was extracted using a slag film simulator. The effect of the high-frequency magnetic field on the microstructure of the mold flux was analyzed using X-ray diffraction, Raman spectroscopy, and mineral phase testing. The results show that the high-frequency electromagnetic field disrupts the orderly movement and increases the movement rate of the liquid flux. The precipitate phase of the slag film did not change, but the silicate dimer Q1 decreased, the chain Q2 increased, and the network degree was increased. The slag film structure changed from the original two-layer form of crystalline layer–glass layer into a three-layer form of crystal layer–glass layer–crystal, and the crystallization ratio increased by 35% on average. The grain-size melilite granularity was reduced from the original 0.12 to 0.005 mm.

scholarly journals Translocation of silica nanospheres through giant unilamellar vesicles (GUVs) induced by a high frequency electromagnetic field

RSC Advances ◽  
2021 ◽  
Vol 11 (50) ◽  
pp. 31408-31420
Author(s):  
Palalle G. Tharushi Perera ◽  
Nevena Todorova ◽  
Zoltan Vilagosh ◽  
Olha Bazaka ◽  
The Hong Phong Nguyen ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Membrane Permeability ◽  
Electromagnetic Fields ◽  
High Frequency ◽  
Model Systems ◽  
Membrane Model ◽  
Silica Nanospheres ◽  
Giant Unilamellar Vesicles ◽  
High Frequency Electromagnetic Field ◽  
First Time

Membrane model systems capable of mimicking live cell membranes were used for the first time in studying the effects arising from electromagnetic fields (EMFs) of 18 GHz where membrane permeability was observed following exposure.

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