scholarly journals Preferential Association of Interferon Regulatory Factor 5 Gene Variants with Seronegative Rheumatoid Arthritis in 2 Swedish Case-Control Studies

2011 ◽  
Vol 38 (10) ◽  
pp. 2130-2132 ◽  
Author(s):  
CHUAN WANG ◽  
HEIDI KOKKONEN ◽  
JOHANNA K. SANDLING ◽  
MARTIN JOHANSSON ◽  
MARIA SEDDIGHZADEH ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interferon Regulatory Factor ◽  
Case Control ◽  
Gene Variants ◽  
Regulatory Factor ◽  
Nucleotide Polymorphism ◽  
Case Control Studies ◽  
Deletion Polymorphism ◽  
Single Nucleotide ◽  
Interferon Regulatory Factor 5

Objective.Two interferon regulatory factor 5 (IRF5) gene variants were examined for association with rheumatoid arthritis (RA).Methods.A total of 2300 patients with RA and 1836 controls were recruited from 2 independent RA studies in Sweden. One insertion-deletion polymorphism (CGGGG indel) and one single-nucleotide polymorphism (rs10488631) in the IRF5 gene were genotyped and analyzed within RA subgroups stratified by rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA).Results.The CGGGG indel was preferentially associated with the RF-negative (OR 1.29, p = 7.9 × 10−5) and ACPA-negative (OR 1.27, p = 7.3 × 10−5) RA subgroups compared to the seropositive counterparts. rs10488631 was exclusively associated within the seronegative RA subgroups (RF-negative: OR 1.24, p = 0.016; ACPA-negative: OR 1.27, p = 4.1 × 10−3).Conclusion.Both the CGGGG indel and rs10488631 are relevant for RA susceptibility, especially for seronegative RA.

Association of Polymorphisms in Interferon Regulatory Factor 5 Gene with Rheumatoid Arthritis: A Metaanalysis

2009 ◽  
Vol 36 (4) ◽  
pp. 693-697 ◽  
Author(s):  
SEUNG WOO HAN ◽  
WON KI LEE ◽  
KI TAE KWON ◽  
BYUNG KI LEE ◽  
EON JEONG NAM ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interferon Regulatory Factor ◽  
Nucleotide Polymorphisms ◽  
Regulatory Factor ◽  
Case Control Studies ◽  
Single Nucleotide ◽  
Funnel Plot ◽  
Interferon Regulatory Factor 5 ◽  
Regression Test

Objective.We investigated potential associations between rheumatoid arthritis (RA) and interferon regulatory factor 5 (IRF5) polymorphisms in a metaanalysis.Methods.This metaanalysis included 5 case-control studies, which provided a total of 6582 RA cases and 5375 controls. Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) inIRF5(rs729302, rs2004640, rs752637, and rs2280714) and data were analyzed in respect to association between alleles.Results.Among 4 candidate SNP, rs729302, rs2004640, and rs2280714 were statistically significant; both allele C of rs729302 and allele G of rs2004640 within the promoter region ofIRF5were associated with a protective effect [random-effects (RE) OR 0.889, 95% confidence interval (CI) 0.803–0.977, p = 0.015 for rs729302; and RE OR 0.905, 95% CI 0.848–0.965, p = 0.002 for rs2004640]. Similar results were also obtained in T allele of rs2280714 in the 3’-untranslated region (RE OR 0.927, 95% CI 0.866–0.992, p = 0.029). There was no evidence of publication bias from funnel-plot asymmetry and Egger’s regression test.Conclusion.Our metaanalysis supported the evidence of the significant role ofIRF5polymorphisms in RA.

scholarly journals Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis

2007 ◽  
Vol 56 (7) ◽  
pp. 2202-2210 ◽  
Author(s):  
Snaevar Sigurdsson ◽  
Leonid Padyukov ◽  
Fina A. S. Kurreeman ◽  
Ulrika Liljedahl ◽  
Ann-Christin Wiman ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Promoter Region ◽  
Interferon Regulatory Factor ◽  
Regulatory Factor ◽  
Interferon Regulatory Factor 5

Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis

2012 ◽  
Vol 40 (2) ◽  
pp. 1791-1799 ◽  
Author(s):  
Young Ho Lee ◽  
Sang-Cheol Bae ◽  
Sung Jae Choi ◽  
Jong Dae Ji ◽  
Gwan Gyu Song
Keyword(s):  
Rheumatoid Arthritis ◽  
Meta Analysis ◽  
Interferon Regulatory Factor ◽  
Regulatory Factor ◽  
Interferon Regulatory Factor 5

scholarly journals Identification and characterisation of single nucleotide polymorphisms in interferon regulatory factor-5 gene of Nigerian local chickens

2021 ◽  
Vol 54 (1) ◽  
pp. 1-13
Author(s):  
Samuel Olutunde Durosaro ◽  
Michael Ohiokhuaobo Ozoje ◽  
Ayotunde Olutumininu Adebambo ◽  
Okanlawon Mohamed Onagbesan
Keyword(s):  
Cell Differentiation ◽  
Single Nucleotide Polymorphisms ◽  
Interferon Regulatory Factor ◽  
Type I ◽  
Nucleotide Polymorphisms ◽  
Regulatory Factor ◽  
Single Nucleotide ◽  
Interferon Regulatory Factor 5 ◽  
Software Packages ◽  
Local Chickens

Abstract The interferon regulatory factor gene family encodes transcription factors with multiple biological functions, which include reproduction, cell differentiation and immunity. Interferon regulatory factor-5 (IRF-5) gene is involved in immune defence against virus, stress response, activation of type I interferon genes, cell differentiation and growth. This experiment was conducted to identify and characterise single nucleotide polymorphisms in exons 3, 4, 5 and 7 of IRF-5 gene in Nigerian local chickens. Exons 3, 4, 5 and 7 of IRF-5 gene were amplified and sequenced. Single nucleotide polymorphisms (SNPs) present in exons 3, 4, 5 and 7 of IRF-5 gene were identified and analysed using Clustal W, DnaSp and SNAP2 software packages. Four SNPs, rs317511101, rs312902332, rs315149141 and rs739389464, were identified in exon 3 of IRF-5 gene in all the three genotypes. Exon 4 of the gene was conserved while three of the SNPs (rs736423928, 170C>T and rs740736761) identified in exon 7 were shared among the three genotypes. Linkage disequilibrium of 1.00 existed between rs317511101 and rs315149141 polymorphisms identified in exon 3 of normal feathered and frizzle feathered chickens. Mutation rs740736761 identified in exon 7 had the highest polymorphism information content obtainable for any biallelic marker. Most of the SNPs identified in exons 3, 5 and 7 were synonymous and singletons which could not be used for association study. The study concluded that only haplotypes in exons 3 and 7 of IRF-5 gene can be used in marker-assisted selection when improving Nigerian local chickens.

Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis

2008 ◽  
Vol 58 (5) ◽  
pp. 1264-1274 ◽  
Author(s):  
Rebeca Dieguez-Gonzalez ◽  
Manuel Calaza ◽  
Eva Perez-Pampin ◽  
Arturo Rodriguez de la Serna ◽  
Benjamin Fernandez-Gutierrez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Interferon Regulatory Factor ◽  
Regulatory Factor ◽  
Systemic Lupus ◽  
Interferon Regulatory Factor 5 ◽  
Large Subgroup

scholarly journals GenotypeAnalytics: a RESTFul platform to mine multiple associations between SNPs and drug response in case-control studies

2017 ◽  
Author(s):  
Giuseppe Agapito ◽  
Pietro H Guzzi ◽  
Mario Cannataro
Keyword(s):  
Drug Response ◽  
Case Control ◽  
Web Browsers ◽  
Drug Reactions ◽  
Nucleotide Polymorphism ◽  
Case Control Studies ◽  
Single Nucleotide ◽  
Speed Up ◽  
Restful Service

We present GenotypeAnalytics (GA), a RESTFul service that makes it possible to mine association rules from Single Nucleotide Polymorphism (SNP) datasets using standard web browsers. GA can speed up and simplify the analysis of this massive amount of data, highlighting only the SNPs involved, for example, in the development of the disease or responsible for adverse drug reactions to the drug. In this way, the doctor may use this extracted knowledge for a significant improvement in the quality of the treatments.

scholarly journals Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations

2008 ◽  
Vol 45 (6) ◽  
pp. 362-369 ◽  
Author(s):  
G Kristjansdottir ◽  
J K Sandling ◽  
A Bonetti ◽  
I M Roos ◽  
L Milani ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Interferon Regulatory Factor ◽  
Gene Variants ◽  
Regulatory Factor ◽  
Interferon Regulatory Factor 5
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