Simultaneous Juvenile Idiopathic Arthritis and Diabetes Mellitus Type 1 — A Finnish Nationwide Study

Objective.To describe the occurrence and main clinical and laboratory findings of patients having both juvenile idiopathic arthritis (JIA) and diabetes mellitus type 1 (DM-1) in a period of 30 years.Methods.Eighty-two patients having simultaneous JIA and DM-1 were identified in the reimbursement registers of the Finnish National Institute of Insurance during the period 1976–2005. Data on their clinical histories were collected from patient files.Results.Occurrence of simultaneous JIA and DM-1 increased 4.5-fold between the first (1976-85) and the last (1996–2005) decade. Prevalence of uveitis was 7%, of rheumatoid factor seropositivity 15%; 22% of patients had a third autoimmune disease [autoimmune disease (AID)], and 16% had serious psychiatric problems.Conclusion.The occurrence of patients with the 2 diseases, JIA and DM-1, increased over 3 decades. The prevalence of uveitis was low, the number of seropositive patients was high, and further cases of AID were frequent. Patients had multiple additional problems necessitating multiprofessional care.

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Two cases of diabetes mellitus type 1 after alemtuzumab treatment for multiple sclerosis: another probable secondary autoimmune disease

Journal of Neurology ◽

10.1007/s00415-019-09257-5 ◽

2019 ◽

Vol 266 (5) ◽

pp. 1270-1271 ◽

Cited By ~ 2

Author(s):

Stephan Richter ◽

Bert Wagner ◽

Elisabeth Gulowsen Celius

Keyword(s):

Diabetes Mellitus ◽

Multiple Sclerosis ◽

Autoimmune Disease ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type

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Assessment of the functional state of the microvasculature in children with diabetes mellitus type 1

Medical Herald of the South of Russia ◽

10.21886/2219-8075-2020-11-2-71-80 ◽

2020 ◽

Vol 11 (2) ◽

pp. 71-80

Author(s):

N. V. Malyuzhinskaya ◽

K. V. Stepanenko ◽

E. I. Volchansky

Keyword(s):

Diabetes Mellitus ◽

Functional State ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Control Group ◽

Healthy Children ◽

Regulation Mechanisms ◽

Glycated Hemoglobin Level ◽

Type 1 Dm

Objective: to assess the functional state of the microvasculature in children with diabetes mellitus type 1 (DM type 1).Materials and methods: 63 children with a verifi ed diagnosis of diabetes mellitus type 1 were examined. Th e control group consisted of 30 practically healthy children. Methods: clinical, paraclinical (determination of glycated hemoglobin level, study of microcirculation indicators using laser Doppler fl owmetry (LDF), statistical.Results: microcirculatory disorders accompanying the course of diabetes mellitus type 1 depending on the length of illness were identifi ed. In children with diabetes mellitus type 1 with standing less than 3 years an increase in the average modulation of blood fl ow mainly due to passive regulation mechanisms and the predominance of hypera adaptation in assessing the functional states of microcirculation of varying severity with an increase in the energy of oscillatory processes were observed. Signs of non-nutritive hyperemia in the zone rich in arteriovenous anastamoses and a decrease in perfusion due to an increase in perfusion fl uctuations and coeffi cient of variation in the distal extremities, as well as a decrease in amplitudes in the active tone-forming range, a gradual decrease in the energy of oscillations and randomness criteria were diagnosed with standing in the duration of the disease.Conclusions: disorders in children with diabetes mellitus type 1 microcirculatory detected using LDF are staged. Th e contribution of non-nutritive blood fl ow to microcirculation increases as the disease progresses, which leads to tissue hypoxia. Evaluation of the combination of energy, information and non-linear parameters of the oscillatory component of the blood flow allows you to identify the type of functional state in the microcirculation system.

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COMPLEX ASSESSMENT OF COMPENSATION IN DIABETES MELLITUS TYPE 1 ACCORDING TO THE RESULTS OF CONTINUOUS GLUCOSE MONITORING

Health and Ecology Issues ◽

10.51523/2708-6011.2016-13-3-26 ◽

2016 ◽

pp. 118-122

Author(s):

E. S. Makhlina ◽

M. P. Kapliyeva ◽

Ya. L. Navmenova ◽

I. G. Savasteyeva

Keyword(s):

Diabetes Mellitus ◽

Continuous Glucose Monitoring ◽

Glucose Monitoring ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Total Daily Dose ◽

Correct Treatment ◽

Risk Indices ◽

Type 1 Dm

Objective: to give complex assessment of compensation in diabetes mellitus type 1 (DM 1) using the continuous glucose monitoring system. Material and methods. The study included 162 patients with DM 1 who were examined using the complex of methods: questionnaire survey, clinical and anamnestic analysis, laboratory investigation of glycohemoglobin level, and continuous glucose monitoring using a CGMS system. Results. The data analysis has showed that only 23% examined patients have adequate control of DM 1. The quality of DM 1 control did not depend on age, DM 1 duration and body mass index (BMI). The highest glycemia variability depended on the total daily dose of injected short action insulin. We have found a high risk for development of hypoglycemia episodes independently of DM 1 quality control. Conclusion. In order to prescribe correct treatment for patients with DM 1, besides the main target criteria of compensation, it is very important to determine the hypoglycemia and hyperglycemia risk indices as well as clinical hypoglycemic reactions for the assessment of DM 1 compensation.

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