scholarly journals A Study of the Renin-Angiotensin System and the Blood Volume in the Nephrotic Syndrome

1986 ◽  
Vol 1 (1) ◽  
pp. 72-78
Author(s):  
Ho Dae Yoo ◽  
Kwang Su Choi ◽  
Man Hong Jung ◽  
Won Sik Lee ◽  
Jae Woo Lee ◽  
...  
1984 ◽  
Vol 62 (2) ◽  
pp. 137-147 ◽  
Author(s):  
John X. Wilson

The mammalian renin–angiotensin system appears to be involved in the maintenance of blood volume and pressure because (i) sodium depletion, hypovolemia, and hypotension increase renin levels, and (ii) administration of exogenous angiotensin II rapidly increases mineralocorticoid and antidiuretic hormone production, transepithelial ion transport, drinking behavior, and peripheral vascular resistance. Are these also the physiological properties of the renin–angiotensin system in nonmammalian species? Signals for altered levels of renin activity have yet to be conclusively identified in nonmammalian vertebrates, but circulating renin levels are elevated by hypotension in teleost fish and birds. Systemic injection of angiotensin II causes an increase in arterial blood pressure in all the vertebrates studied, suggesting that barostatic control is a universal function of this hormone. Angiotensin II alters vascular tone by direct action on arteriolar muscles in some species, but at concentrations of the hormone which probably are unphysiological. More generally, angiotensin II increases blood pressure indirectly, by acting on the sympathetic nervous system. Catecholamines, derived from chromaffin cells and (or) from peripheral adrenergic nerves, mediate some portion of the vasopressor response to angiotensin II in cyclostomes, elasmobranchs, teleosts, amphibians, reptiles, mammals, and birds. Alteration of sympathetic outflow is a prevalent mechanism through which the renin–angiotensin system may integrate blood volume, cardiac output, and peripheral vascular resistance to achieve control of blood pressure and adequate perfusion of tissues.


Nephron ◽  
1974 ◽  
Vol 12 (4) ◽  
pp. 233-240 ◽  
Author(s):  
A. Medina ◽  
D.L. Davies ◽  
J.J. Brown ◽  
R. Fraser ◽  
A.F. Lever ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document