scholarly journals Incidence and factors associated with prescribing renin‐angiotensin‐system inhibitors in adult idiopathic nephrotic syndrome: A nationwide cohort study

2021 ◽  
Author(s):  
Hiroki Nishiwaki ◽  
Kakuya Niihata ◽  
Sayaka Shimizu ◽  
Yugo Shibagaki ◽  
Ryohei Yamamoto ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cohort Study ◽  
Idiopathic Nephrotic Syndrome ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Factors Associated

scholarly journals A Study of the Renin-Angiotensin System and the Blood Volume in the Nephrotic Syndrome

1986 ◽  
Vol 1 (1) ◽  
pp. 72-78
Author(s):  
Ho Dae Yoo ◽  
Kwang Su Choi ◽  
Man Hong Jung ◽  
Won Sik Lee ◽  
Jae Woo Lee ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Blood Volume ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals The effect of initiation of renin–angiotensin system inhibitors on haemoglobin: A national cohort study

2020 ◽  
Author(s):  
George H.B. Greenhall ◽  
Kathryn E. Mansfield ◽  
Dorothea Nitsch ◽  
Masao Iwagami ◽  
Clémence Leyrat ◽  
...  
Keyword(s):  
Cohort Study ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
National Cohort

scholarly journals Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1367
Author(s):  
Fabrizio Pucci ◽  
Philippe Bogaerts ◽  
Marianne Rooman
Keyword(s):  
Renin Angiotensin System ◽  
Therapeutic Strategies ◽  
Spike Protein ◽  
Angiotensin System ◽  
Angiotensin Converting Enzyme 2 ◽  
Pathogenic Mechanisms ◽  
Renin Angiotensin ◽  
Factors Associated ◽  
Ras Blockers ◽  
The Impact

SARS-CoV-2 infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors associated with COVID-19 coronavirus disease and to design effective therapeutic strategies. In this context, we developed a mathematical model of RAS based on data regarding protein and peptide concentrations; the model was tested on clinical data from healthy normotensive and hypertensive individuals. We used our model to analyze the impact of SARS-CoV-2 infection on RAS, which we modeled through a downregulation of ACE2 as a function of viral load. We also used it to predict the effect of RAS-targeting drugs, such as RAS-blockers, human recombinant ACE2, and angiotensin 1–7 peptide, on COVID-19 patients; the model predicted an improvement of the clinical outcome for some drugs and a worsening for others. Our model and its predictions constitute a valuable framework for in silico testing of hypotheses about the COVID-19 pathogenic mechanisms and the effect of drugs aiming to restore RAS functionality.

scholarly journals Renin–angiotensin system blockade and kidney transplantation: a longitudinal cohort study

2011 ◽  
Vol 27 (1) ◽  
pp. 417-422 ◽  
Author(s):  
Domingo Hernández ◽  
Alfonso Muriel ◽  
Víctor Abraira ◽  
Germán Pérez ◽  
Esteban Porrini ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Renin Angiotensin System ◽  
Longitudinal Cohort Study ◽  
Angiotensin System ◽  
Longitudinal Cohort ◽  
Renin Angiotensin
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