Scutellaria topcuoglui (Lamiaceae) from Muğla Province (south-western Anatolia) is described as a new species to science. The new species is morphologically similar to S. glaphyrostachys, but differs from it by several morphological characters, such as the presence of glandular hairs in stems, leaves, bracts, calyx and corolla, scutellum length, corolla length, coloration, and indumentum, mericarp length, coloration, and sculpture, pollen shape, and habitat preference. Diagnostic characters, a comprehensive description, photographs, and a distribution map are provided.