scholarly journals Frequency and Characteristics of the Neonatal Sepsis Infections Caused by Extended-Spectrum Beta-Lactamase (ESBL) Producing and Non-Producing Organisms in the Chittagong Area of Bangladesh

2014 ◽  
Vol 5 (1) ◽  
pp. 1-12
Author(s):  
Muhammad Ehteshamul Haque ◽  
Abu Sayeed Mohammad Mahmud ◽  
Muhammad Shahjalal Khan ◽  
Naznin Akhtar ◽  
Mohammad Seraj Uddin ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum

scholarly journals Chorioamnionitis and Neonatal Sepsis Due to Extended Spectrum Beta-Lactamase producing Escherichia Coli Infection: A Case Report

2021 ◽  
Author(s):  
Saheed Shittu ◽  
Sufia Athar ◽  
Adila Shaukat ◽  
Lolwa Alansari
Keyword(s):  
Escherichia Coli ◽  
Neonatal Sepsis ◽  
Adverse Outcomes ◽  
Beta Lactamase ◽  
Drug Resistant ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum ◽  
Escherichia Coli Infection ◽  
Prolonged Hospital

Chorioamnionitis, a common complication of pregnancy is associated with significant maternal, perinatal, and long-term adverse outcomes. This case of placental infection leading to preterm delivery, severe neonatal sepsis, maternal wound infection, postnatal readmission, and prolonged hospital stay was caused by multi-drug resistant Extended Spectrum Beta Lactamase (ESBL)-producing Escherichia Coli

scholarly journals Multi-drug resistance in early and late onset neonatal sepsis in a tertiary hospital in Nigeria

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Lateefat O. Sa’adu ◽  
Tope O. Obasa ◽  
Aishat O. Saka ◽  
Mohammed J. Saka ◽  
Charles Nwabuisi
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Klebsiella Pneumoniae ◽  
Neonatal Sepsis ◽  
Late Onset ◽  
Resistant Isolate ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum ◽  
Antibiotic Susceptibility Test

Neonatal sepsis is a clinical syndrome characterized by systemic signs of infection, and accompanied by bacteremia in the first month of life and is responsible for 30-50% of total neonatal deaths, each year in developing countries. This study investigated multi-drug resistant organisms associated with early and late onset neonatal sepsis in the University of Ilorin Teaching Hospital (UITH). It was a descriptive cross-sectional study. One hundred and sixty-two blood samples from neonates admitted into the neonatal intensive care unit of UITH with clinical diagnosis of sepsis were obtained. One milliliter of blood was taken per neonate and cultured aerobically in brain heart infusion broth and sub cultured onto blood and MacConkey agar plates. Identification of the isolates was carried out by colonial morphology, Gram stain microscopy and several biochemical tests. Antibiotic susceptibility test was done using the modified Kirby-Bauer method, screening for methicillin resistance Staphylococcus aureus (MRSA) and extended spectrum beta lactamase (ESBL) was done by the cefoxiin- based methods and double disc synergy test respectively. Data analysis was carried out using Microsoft excel version 2007 and Epi-info version 2012. Sepsis was confirmed bacteriologically in 22.2% of the samples. The prevalence of multidrug resistant isolate was 29.0%. The prevalence of MRSA was found to be 37% while that of ESBL producing Enterobacteria was 44.4% with ESBL producing Klebsiella pneumoniae and Escherichia coli prevalence of 50% and 25% respectively. This study shows a high prevalence of Methicillin Resistant Staphylococcus Aureus and Extended Spectrum Beta Lactamase producing Klebsiella pneumoniae and Escherichia coli causing neonatal sepsis in UITH Ilorin.

Molecular Characterization of Methicillin Resistant and Extended Spectrum β-Lactamase Staphylococcus aureus Isolated from Burn Patients

2020 ◽  
pp. 145-151
Author(s):  
Shawnm Ahmed Aziz
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistance ◽  
Vancomycin Resistance ◽  
World Health ◽  
Molecular Technique ◽  
Burn Patients ◽  
Beta Lactamase ◽  
Beta Lactam ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum

Antibiotic resistance has become a major world health challenge and has limited the ability of physician's treatment. Staphylococcus aureus the most notorious pathogens causes morbidity and mortality especially in burn patients. However, Staphylococcus aureus rapidly acquired resistance to multiple antibiotics. Vancomycin, a glycopeptide antibiotic remains a drug of choice for treatment of severe Methicillin Resistance S. aureus infections. This study aimed to detect the emergence of beta-lactam and glycopeptide resistance genes. 50 clinical specimens of S. aureus collected from burn patients in burn and plastic surgery units in Sulaimani-Iraq city. All specimens were confirmed to be positive for S. aureus. All the isolates were assessed for their susceptibility to different antibiotics depending on NCCL standards, followed by Extended Spectrum Beta Lactamase detection by double disk diffusion synergy test. The production of β- lactamases was evaluated in the isolated strains by several routine methods and polymerase chain reaction. Among the isolates 94% were Methicillin resistance and 34.28% were Extended Spectrum Beta Lactamase producer. PCR based molecular technique was done for the bla genes related to β- lactamase enzymes by the specific primers, as well as genes which related to reduced sensitivity to Vancomycin were detected. The results indicated that all isolated showed the PBP1, PBP2, PBP3, PBP4, trfA and trfB, graSR, vraS except the vraR gene and the prolonged therapy of Methicillin resistance infection with teicoplanin have been associated with progress of resistance and the rise of tecoplanin resistance may be a prologue to evolving Vancomycin resistance. In conclusion, beta-lactam over taking can rise Vancomycin- Intermediate S. aureus strains leading to appearance of Vancomycin resistance although the treatment of Vancomycin resistant infections is challenging.

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