Correlation Between Matrix Metalloproteinase 8 in Gingival Crevicular Fluid and Zinc Consumption

2015 ◽  
Vol 15 (1) ◽  
pp. 72-75 ◽  
Author(s):  
Nila Kasuma ◽  
Fadil Oenzil ◽  
Nur Indrawaty Lipoeto
Keyword(s):  
Matrix Metalloproteinase ◽  
Gingival Crevicular Fluid ◽  
Crevicular Fluid

scholarly journals Origin of MMP-8 and Lactoferrin levels from gingival crevicular fluid, salivary glands and whole saliva

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Liza L. Ramenzoni ◽  
Deborah Hofer ◽  
Alex Solderer ◽  
Daniel Wiedemeier ◽  
Thomas Attin ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Salivary Glands ◽  
Gingival Crevicular Fluid ◽  
Clinical Parameters ◽  
Pocket Depth ◽  
Active Matrix ◽  
Probing Pocket Depth ◽  
Whole Saliva ◽  
Biomarker Testing ◽  
Crevicular Fluid

Abstract Background Pathologically elevated levels of matrix metalloproteinase-8 (MMP-8) and Lactoferrin in oral fluids have been associated with the presence of gingivitis/periodontitis. This study aimed to assess the origin of MMP-8 and Lactoferrin in periodontitis patients and to identify the degree to which conventional clinical parameters correlate with their presence. Methods A total of ten periodontitis and ten healthy patients were included in this study. Whole saliva (stimulated and unstimulated), parotid/sublingual glandular fluid and gingival crevicular fluid from pockets and sulci were tested for MMP-8 and Lactoferrin and protein concentrations were quantified using an ELISA assay. Clinical parameters were checked for potential associations with MMP-8 and Lactoferrin levels. Results Periodontal patients presented higher concentrations of MMP-8 and Lactoferrin in pockets than other sources (P = 0.03). Lactoferrin measurement was higher in the parotid compared to sublingual glandular fluid in periodontitis patients (P = 0.03). Increased probing pocket depth was positively correlated with high MMP-8 and Lactoferrin levels. Conclusions Periodontal pockets appear to be the major source of active matrix metalloproteinase and Lactoferrin, which also may also enter the oral cavity through the salivary glands. Since clinically healthy sites in periodontitis patients also had elevated biomarker levels, gingival crevicular fluid biomarker testing may be more predictive of future tissue breakdown than conventional clinical parameters.

scholarly journals Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Petra Surlin ◽  
Isabela Silosi ◽  
Anne Marie Rauten ◽  
Manole Cojocaru ◽  
Lili Foia
Keyword(s):  
Matrix Metalloproteinase ◽  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Good Control ◽  
Matrix Metalloproteinase 9 ◽  
Lipocalin 2 ◽  
Orthodontic Appliance ◽  
Bacterial Plaque ◽  
Crevicular Fluid ◽  
Metalloproteinase 9

In the present study the aim was to measure the levels of Thrombospondin-1 (TSP1) and Lipocalin-2/matrix metalloproteinase 9 (MMP9/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total-matrix metalloproteinase 9 (MMP9) and theirs implication in angiogenesis balance, in the situation of a good control of the bacterial plaque, emphasizing the role of TSP1 and MMP9/NGAL complex. GCF samples were collected from 16 young orthodontic patients requiring upper canine distalization (test tooth) with first premolar extraction. The contralateral canine (control tooth) was free from orthodontic force. For the orthodontic appliance, brackets Roth 0.018 inch with 0.012 inch NiTi archwire and a laceback were used. TSP1, MMP9/NGAL, and MMP9 increased from 1 hour before activation of orthodontic appliance to a maximum at 8 hours for MMP9 and 72 hours for MMP9/NGAL and TSP1. The results show a change in time of TSP1, MMP9/NGAL, and MMP9 levels in GCF of patients with this method of orthodontic treatment. The powerful correlation of MMP9/NGAL with TSP1 suggests their stronger involvement in angiogenesis processes in PDL during orthodontic periodontal remodeling, in the situation of a healthy periodontium and a good control of the bacterial plaque.

scholarly journals Changes in Matrix Metalloproteinase-8, Interleukin-6 and Tu-mor Necrosis Factor-Α in Gingival Crevicular Fluid during Rap-id Maxillary Expansion in Adolescent Patients

2021 ◽  
Author(s):  
Zhipeng Tang ◽  
Dongxue Mi ◽  
Hao Wu ◽  
Yanan Fu ◽  
Li Liu ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Gingival Crevicular Fluid ◽  
Control Group ◽  
Observation Group ◽  
Periodontal Tissue ◽  
Maxillary Expansion ◽  
Clinical Indicators ◽  
Tnf Α ◽  
Crevicular Fluid ◽  
Necrosis Factor

Background: Rapid maxillary expansion (RME) is the standard treatment for correcting lateral maxillary defects commonly used in orthodontics. It is the most effective approach to increase maxillary width in clinical practice. At present, there are few studies on the level of molecular biology of periodontal tissue remodeling during RME. We aimed to investigate changes in matrix metalloproteinase (MMP)-8, interleukin (IL)-6 and tumor necrosis factor (TNF)-αin gingival crevicular fluid during RME. Methods: Patients admitted to Department of Stomatology, the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang Province, China between Dec 2016 and Dec 2018 were enrolled, and randomly divided into the observation group (76 cases) and control group (62 cases). Periodontal clinical indicators were recorded. Gingival crevicular fluid was collected and the periodontal clinical indicators were recorded. The levels of MMP-8, IL-6 and TNF-α were determined by ELISA, and the contents of the two groups were compared. Results: The plaque index of the observation group was significantly higher than that of the baseline T0 (P< 0.05) from T4, and the increase in the control group started from T5. The general clinical data of the two groups showed that the white blood cell count of the observation group was higher than that of the control group. The levels of MMP-8, IL-6 and TNF-α were the highest at T2, followed by T3, and gradually decreased at T4, and T5, and the differences were significant (P<0.05). Conclusion: The changes in levels of MMP-8, IL-6 and TNF-α in adolescent patients during RME were related to the remodeling of periodontal tissue after RME.

Gingival Crevicular Fluid Matrix Metalloproteinase-8 Levels Predict Treatment Outcome Among Smokers With Chronic Periodontitis

2014 ◽  
Vol 85 (2) ◽  
pp. 250-260 ◽  
Author(s):  
Jussi M. Leppilahti ◽  
Mikko A. Kallio ◽  
Taina Tervahartiala ◽  
Timo Sorsa ◽  
Päivi Mäntylä
Keyword(s):  
Treatment Outcome ◽  
Matrix Metalloproteinase ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Crevicular Fluid
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