Enhanced levels of prostaglandin E2, leukotriene B4, and matrix metalloproteinase-9 in gingival crevicular fluid from patients with Down syndrome

2003 ◽  
Vol 61 (3) ◽  
pp. 154-158 ◽  
Author(s):  
Georgios Tsilingaridis ◽  
Tülay Yucel-Lindberg ◽  
Thomas Modéer
Keyword(s):  
Down Syndrome ◽  
Matrix Metalloproteinase ◽  
Prostaglandin E2 ◽  
Gingival Crevicular Fluid ◽  
Leukotriene B4 ◽  
Matrix Metalloproteinase 9 ◽  
Crevicular Fluid ◽  
Metalloproteinase 9

scholarly journals Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Petra Surlin ◽  
Isabela Silosi ◽  
Anne Marie Rauten ◽  
Manole Cojocaru ◽  
Lili Foia
Keyword(s):  
Matrix Metalloproteinase ◽  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Good Control ◽  
Matrix Metalloproteinase 9 ◽  
Lipocalin 2 ◽  
Orthodontic Appliance ◽  
Bacterial Plaque ◽  
Crevicular Fluid ◽  
Metalloproteinase 9

In the present study the aim was to measure the levels of Thrombospondin-1 (TSP1) and Lipocalin-2/matrix metalloproteinase 9 (MMP9/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total-matrix metalloproteinase 9 (MMP9) and theirs implication in angiogenesis balance, in the situation of a good control of the bacterial plaque, emphasizing the role of TSP1 and MMP9/NGAL complex. GCF samples were collected from 16 young orthodontic patients requiring upper canine distalization (test tooth) with first premolar extraction. The contralateral canine (control tooth) was free from orthodontic force. For the orthodontic appliance, brackets Roth 0.018 inch with 0.012 inch NiTi archwire and a laceback were used. TSP1, MMP9/NGAL, and MMP9 increased from 1 hour before activation of orthodontic appliance to a maximum at 8 hours for MMP9 and 72 hours for MMP9/NGAL and TSP1. The results show a change in time of TSP1, MMP9/NGAL, and MMP9 levels in GCF of patients with this method of orthodontic treatment. The powerful correlation of MMP9/NGAL with TSP1 suggests their stronger involvement in angiogenesis processes in PDL during orthodontic periodontal remodeling, in the situation of a healthy periodontium and a good control of the bacterial plaque.

Matrix Metalloproteinase 9 is Regulated by LOX-1 and erk1/2 Pathway in Dental Peri-Implantitis

2020 ◽  
Vol 21 (9) ◽  
pp. 862-871
Author(s):  
Qian Zhang ◽  
Haitao Xu ◽  
Na Bai ◽  
Fei Tan ◽  
Huirong Xu ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Soft Tissues ◽  
Regulatory Mechanism ◽  
Quantitative Polymerase Chain Reaction ◽  
Matrix Metalloproteinase 9 ◽  
Human Macrophages ◽  
Mmp9 Expression ◽  
Oral Implant ◽  
Crevicular Fluid ◽  
Metalloproteinase 9

Background and Objective: Dental peri-implantitis, which can be caused by several different microbial factors, is characterized by inflammatory lesions of the surrounding hard and soft tissues of an oral implant. Matrix Metalloproteinase 9 (MMP9) is thought to be involved in the pathogenesis of peri-implantitis. However, the regulatory mechanism of MMP9 in peri-implantitis has not been fully elucidated. In this study, we tried to evaluate the regulatory mechanism of MMP9 in peri-implantitis. Methods: We collected Peri-Implant Crevicular Fluid (PICF) from ten healthy implants and ten periimplantitis patients and compared their expression level of MMP9. We also cultured macrophages from the peripheral blood of healthy volunteers infected by Porphyromonas gingivalis to reveal the regulatory mechanism of MMP9 in peri-implantitis. Western blot, immunofluorescence staining and quantitative Polymerase Chain Reaction (RT-PCR) were used to better characterize the mechanism of MMP9. Results: The expression of MMP9 was up-regulated in peri-implantitis patient PICF and P. gingivalis infected human macrophages. LOX-1, not dectin-1, was found to mediate MMP9 expression in human macrophages with P. gingivalis infection. Expression of Erk1/2 was responsible for infection-induced MMP9 expression. Finally, use of a broad-spectrum metalloproteinase inhibitor impaired LOX-1 expression in infected macrophages. Conclusion: Our results demonstrate that MMP9 is involved in dental peri-implantitis and is regulated by LOX-1 and Erk1/2. This LOX-1/MMP9 signaling pathway may represent a potential drug target for peri-implantitis.

scholarly journals Suppression of Matrix Metalloproteinase-9 by Prostaglandin E2 in Peritoneal Macrophage Is Associated with Severity of Endometriosis

2005 ◽  
Vol 167 (4) ◽  
pp. 1061-1069 ◽  
Author(s):  
Meng-Hsing Wu ◽  
Yutaka Shoji ◽  
Meng-Chi Wu ◽  
Pei-Chin Chuang ◽  
Chen-Chung Lin ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Prostaglandin E2 ◽  
Peritoneal Macrophage ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

scholarly journals Levels of Myeloperoxidase and Metalloproteinase-9 in Gingival Crevicular Fluid from Diabetic Subjects with and without Stage 2, Grade B Periodontitis

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Diana C. Peniche-Palma ◽  
Bertha A. Carrillo-Avila ◽  
Eduardo A. Sauri-Esquivel ◽  
Karla Acosta-Viana ◽  
Vicente Esparza-Villalpando ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Matrix Metalloproteinase ◽  
Gingival Crevicular Fluid ◽  
Luminex Assay ◽  
Apparent Relationship ◽  
Crevicular Fluid ◽  
Metalloproteinase 9

Objective.The present study aimed to compare levels of matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) in gingival crevicular fluid (GCF) from subjects with controlled and noncontrolled Type 2 Diabetes Mellitus (T2D), with and without stage 2 grade B periodontitis (POD2B) versus healthy (H) subjects.Methods.The levels of both enzymes, from 80 GCF samples collected with PerioPaper strips, were analyzed by a Multiplex/Luminex assay. Five groups were formed, all current patients at the Institutional Dentistry Service, and distributed as follows: two groups of diabetics (one controlled and one poorly controlled); two groups with the previous conditions and diagnosed with POD2B; and one H group.Results.The highest concentration of MMP-9 corresponded to the H group, while the lowest corresponded to the T2D controlled group. Regarding MPO levels, the highest levels were associated with the T2D controlled with POD2B group and the lowest with the T2D controlled group.Conclusions.No apparent relationship between the elevation of MMP-9 and MPO levels was observed among subjects with T2D, with and without POD2B, compared to H subjects.

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