Celiac Disease Prevalence and its HLA-genotypic Profile in Egyptian Patients with Type 1 Diabetes Mellitus

2014 ◽  
Vol 9 (2) ◽  
pp. 81-97 ◽  
Author(s):  
Mohammed Amin Mohammed ◽  
Nesreen Moustafa Omar ◽  
Abdelhadi M. Shebl ◽  
Amany H. Mansour ◽  
Emad Elmasry ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Disease Prevalence ◽  
Egyptian Patients ◽  
Genotypic Profile

The prevalence, immune profile, and clinical characteristics of children with celiac disease and type 1 diabetes mellitus in the state of Qatar

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Basma Haris ◽  
Ahmed Abdellatief ◽  
Houda Afyouni ◽  
Tasneem Abdel-Karim ◽  
Shayma Mohammed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Characteristics ◽  
Family History Of Diabetes ◽  
Positive Type ◽  
Immune Profile ◽  
Insulin Autoantibody

Abstract Objectives Children with antibody positive type 1 diabetes mellitus (type 1 diabetes) are at an increased risk of developing celiac disease (CD) which suggests a common autoimmune basis with both high-risk human lymphocyte antigen (HLA) and non-HLA factors playing a role in the pathophysiology. We aim to describe the prevalence, immune profile, and clinical characteristics of children with CD who have type 1 diabetes mellitus in Qatar. Methods All children (aged 0–18 years) attending a regional diabetes clinic with antibody positive type 1 diabetes were screened for CD. Measurement of tissue transglutaminase IgA and IgG as well as anti-endomysial antibody, was done, clinical details about the birth history, family history of diabetes and CD, age of onset, and ethnicity were collected. Results Out of the 1,325 children with antibody positive type 1 diabetes, 54 were identified to have CD on screening and then confirmed on small bowel biopsy. The prevalence of CD in the type 1 diabetes childhood population in Qatar is 4.07%. CD and type 1 diabetes were more prevalent in the Qatari children (n=32) as compared to non-Qatari (n=22) and occurred mostly in the age group 6–10 years. The most common type 1 diabetes antibodies in children with CD were glutamic acid decarboxylase and insulin autoantibody. Twelve subjects were asymptomatic for CD symptoms and picked up only on screening. Conclusions The prevalence of CD in children with type 1 diabetes in Qatar is comparable to reports from around the world. Many children were asymptomatic and thus routine screening is recommended.

Type 1 Diabetes Mellitus, Celiac Disease and NASH-Related Cirrhosis in a 3-Year-Old Boy with Acquired Generalized Lipodystrophy

2011 ◽  
pp. P3-746-P3-746
Author(s):  
Monica Grover ◽  
Andrea Erika Balazs ◽  
Carlos A Bacino ◽  
Christian Patrick Schaaf ◽  
Saul J Karpen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus

Increased prevalence of disordered eating in the dual diagnosis of type 1 diabetes mellitus and celiac disease

2018 ◽  
Vol 19 (4) ◽  
pp. 749-755 ◽  
Author(s):  
Itay Tokatly Latzer ◽  
Marianna Rachmiel ◽  
Nehama Zuckerman Levin ◽  
Kineret Mazor-Aronovitch ◽  
Zohar Landau ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Disordered Eating ◽  
Dual Diagnosis

AACE2021-A-1074: Occurrence of Celiac Disease and Socio-Demographic Parameters in Type-1 Diabetes Mellitus

2021 ◽  
Vol 27 (12) ◽  
pp. S38
Author(s):  
Paras Imran ◽  
Saeeda Fouzia Qasim ◽  
Saba Latif ◽  
Mohammad Yahya ◽  
Saima Athar Shaikh
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Demographic Parameters

scholarly journals Prevalence of Celiac Disease in Omani Children with Type 1 Diabetes Mellitus: A Cross Sectional Study

2013 ◽  
Vol 28 (4) ◽  
pp. 260-263 ◽  
Author(s):  
Siham Al-Sinani ◽  
Sharef Waadallah Sharef ◽  
Saif Al-Yaarubi ◽  
Ibrahim Al-Zakwani ◽  
Khalid Al-Naamani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Interplay between Type 1 Diabetes Mellitus and Celiac Disease: Implications in Treatment

2018 ◽  
Vol 36 (6) ◽  
pp. 399-408 ◽  
Author(s):  
Navchetan Kaur ◽  
Sanjay K. Bhadada ◽  
Ranjana W. Minz ◽  
Devi Dayal ◽  
Rakesh Kochhar
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Prevalence Rate ◽  
Vascular Complications ◽  
Complex Situation ◽  
Disease Etiology ◽  
Organ Specific

Background: A complex interplay between genetic and environmental factors contributes to disease etiology of most of the autoimmune disorders. Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are polygenic autoimmune diseases that have high propensity to coexist due to shared etiological factors like genetics and clinico-pathological overlaps. Summary: The mean prevalence rate for coexistence of these diseases is 8%, and this value is a gross underestimation as reported from biopsy-proven symptomatic cases. The prevalence rate will rise when studies will excavate bottom layers of the “celiac iceberg” to detect potential and silent celiac cases. The concomitant presence of both these disorders is a complex situation immunologically as well as clinically. There is an accentuated breakdown of tolerance and proinflammatory cytokine storm that leads to the progression of organ-specific autoimmunity to systemic. No immunomodulating drugs are advocated as exogenous insulin supplementation and gluten exclusion are recommended for T1DM and CD respectively. Nevertheless, these pose certain challenges to both the clinicians and the patients, as gluten free diet (GFD) has been described to have an impact on glycemic control, bone health, and vascular complications. Also intermittent gluten intake by these patients due to non-compliance with GFD also stimulates the autoreactive immune cells that result in an augmented immune response. Key Messages: Large public health studies are needed to estimate the prevalence of all forms of CD in T1DM patients. Strict global guidelines need to be formulated for the disease management and prognosis, and there is also a need for an extensive research on each front to thoroughly understand the co-occurrence of these diseases.

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