Autism Genetics and Cytogenetic Abnormalities

2011 ◽  
Vol 3 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Vandana Rai
Keyword(s):  
Cytogenetic Abnormalities ◽  
Autism Genetics

Cytogenetic abnormalities in PHA-stimulated lymphocytes from patients with Langerhans cell histiocytosis

2000 ◽  
Vol 111 (1) ◽  
pp. 258-262 ◽  
Author(s):  
Susi Scappaticci ◽  
Cesare Danesino ◽  
Elena Rossi ◽  
Catherine Klersy ◽  
Gian Mario Fiori ◽  
...  
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Cytogenetic Abnormalities

265 Hemivertebra: systematic review of cases with cytogenetic abnormalities, associated anomalies and proposed prenatal management

2021 ◽  
Vol 224 (2) ◽  
pp. S175
Author(s):  
Jennifer E. Powel ◽  
Michail Spiliopoulos ◽  
Carlos R. Ferreira ◽  
Emily Rosenthal ◽  
Elena Sinkovskaya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Associated Anomalies ◽  
Cytogenetic Abnormalities ◽  
Prenatal Management

scholarly journals Nonrandom cytogenetic changes accompany malignant progression in clonal lines abelson virus-infected lymphocytes

Blood ◽  
1994 ◽  
Vol 84 (12) ◽  
pp. 4301-4309 ◽  
Author(s):  
SS Clark ◽  
Y Liang ◽  
CK Reedstrom ◽  
SQ Wu
Keyword(s):  
Tumor Progression ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Lymphoid Cells ◽  
Full Transformation ◽  
Cytogenetic Abnormalities ◽  
Cytogenetic Changes ◽  
Abelson Murine Leukemia Virus ◽  
Murine Leukemia ◽  
Over Time

Initially, lymphoid cells transformed by v-abl or BCR/ABL oncogenes are poorly oncogenic but progress to full transformation over time. Although expression of the oncogene is necessary to initiate and maintain transformation, other molecular mechanisms are thought to be required for full transformation. To determine whether tumor progression in ABL oncogene-transformed lymphoid cells has a genetic basis, we examined whether progression of the malignant phenotype of transformed clones correlates with particular cytogenetic abnormalities. A modified in vitro bone marrow transformation model was used to obtain clonal Abelson murine leukemia virus-transformed B lymphoid cells that were poorly oncogenic. Multiple subclones were then derived from each clone and maintained over a marrow-derived stromal cell line for several weeks. Over time, clonally related Abelson murine leukemia virus-transformed subclones progressed asynchronously to full transformation. The data show that tumor progression can occur in the absence of detectable cytogenetic changes but, more importantly, that certain cytogenetic abnormalities appear reproducibly in highly malignant subclones. Therefore, three independent subclones showed deletion in a common region of chromosome 13. Other highly malignant cells carried a common breakpoint in the X chromosome, and, finally, two subclones carried an additional chromosome 5. These results are consistent with the hypothesis that ABL oncogenes are sufficient for the initial transformation of cells but that additional genetic events can drive oncogenic progression. These observations further suggest that diverse genetic mechanisms may be able to drive tumor progression in cells transformed with ABL oncogenes.

scholarly journals R-066. Cytoskeletal and cytogenetic abnormalities during the in-vitro maturation of mouse oocytes exposed to cocaine

1999 ◽  
Vol 14 (Suppl_3) ◽  
pp. 308-308
Author(s):  
C.M.H. Combelles ◽  
M.J. Carabatsos ◽  
J.B. Mailhes ◽  
S.N. London ◽  
D.F. Albertini
Keyword(s):  
In Vitro Maturation ◽  
Cytogenetic Abnormalities ◽  
Mouse Oocytes

scholarly journals Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia

2011 ◽  
Vol 28 (3) ◽  
pp. 176-185
Author(s):  
Milena Georgieva Velizarova ◽  
Evgueniy A. Hadjiev ◽  
Kamelia V. Alexandrova ◽  
Ivanka I. Dimova ◽  
Draga I. Toncheva ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Complete Remission ◽  
Lymphoblastic Leukemia ◽  
Cytogenetic Abnormalities ◽  
Adult Acute Lymphoblastic Leukemia ◽  
First Complete Remission

Residual risk for cytogenetic abnormalities after prenatal diagnosis by interphase fluorescencein situ hybridization (FISH)

2003 ◽  
Vol 23 (7) ◽  
pp. 566-571 ◽  
Author(s):  
Jeanne Homer ◽  
Sucheta Bhatt ◽  
Bing Huang ◽  
Maya Thangavelu
Keyword(s):  
Prenatal Diagnosis ◽  
Residual Risk ◽  
Fluorescencein Situ Hybridization ◽  
Cytogenetic Abnormalities

scholarly journals Autism genetics: Methodological issues and experimental design

2015 ◽  
Vol 58 (10) ◽  
pp. 946-957 ◽  
Author(s):  
Roberto Sacco ◽  
Carla Lintas ◽  
Antonio M. Persico
Keyword(s):  
Experimental Design ◽  
Methodological Issues ◽  
Autism Genetics
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