scholarly journals MANAGEMENT OF OBSTETRIC HEMORRHAGE BASED ON URGENCY AT BLOOD TRANSFUSION SERVICE: QUESTIONNAIRE ON OBSTETRIC HEMORRHAGE AND BLOOD TRANSFUSION SYSTEM CONDUCTED BY THE KANAGAWA PREFECTURAL JOINT COMMITTEE OF BLOOD TRANSFUSION THERAPY

2016 ◽  
Vol 62 (3) ◽  
pp. 470-475
Author(s):  
Hisako Okada ◽  
Hisayo Ogawa ◽  
Fumiaki Yoshiba ◽  
Junichi Terauchi ◽  
Akira Ito ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Obstetric Hemorrhage ◽  
Transfusion Therapy ◽  
Blood Transfusion Service

scholarly journals Results of the Study of Morphological Features and Serotonin Accumulative Function of Platelets in Blood Donors

2021 ◽  
Vol 6 (5) ◽  
pp. 214-219
Author(s):  
O. V. Muliarchuk ◽  
◽  
S. V. Vydyborets
Keyword(s):  
Blood Transfusion ◽  
Peripheral Blood ◽  
Blood Donors ◽  
Blood Platelets ◽  
Control Group ◽  
Transfusion Therapy ◽  
Blood Transfusion Service ◽  
Donated Blood ◽  
Primary Reserve

Blood transfusion service and its social component – donorship must be the priority areas of the state policy because the results of its work are of paramount importance. The main task of the blood transfusion service is supply of high quality components for blood transfusion therapy. Quality of blood components is compliance of properties and specifications of the blood component supplied to the recipient with the set standards. Strict order of conformance with the approved regulations and procedures is important at all technological states and is a cornerstone of blood transfusion service products quality. All actions, planned and implemented, starting with planning donorship and ending with the finished product manufacturing and storage conditions, are important for ensuring the quality as the final result. The purpose of the study was to determine the content of total, platelet and free serotonin in the plasma of primary and active blood donors for further use of the studied parameters to assess the quality of platelet concentrate. Materials and methods. 160 blood donors (118 men and 42 women) were examined, including 110 active donors (85 men and 25 women) who donated blood regularly at least 3 times a year and 50 primary reserve donors (32 men and 18 women), who donated blood for the first time. Primary reserve donors formed a control group. For the convenience of systematization and reproduction of scientific research results, objectification in comparing research data, all examined active donors, depending on the duration of donor experience and, accordingly, increasing the probability of occurrence of hidden platelet metabolism disorder, were divided into three subgroups: subgroup I – 51 donors (39 men and 12 women), whose donor experience lasted from 2 to 5 years; subgroup II – 31 donors (24 men and 7 women), duration of donor experience which ranged from 6 to 9 years; subgroup III – 28 donors (22 men and 6 women), whose donor experience lasted 10 years or more. The method of fractional determination of biological amines – serotonin – is presented in preliminarily dried biostrate specimens. The method described includes some extraction procedures with optimal controlled pH values necessary for isolating serotonin, producing fluorophors in accordance with orthophtaldialdehide and ninhydrin, the subsequent fluorimetric estimation of their levels being performed on the native fluorometer «БИАН». Results and discussion. It was found that active donors compared to control, have a level of free serotonin in peripheral blood platelets which was significantly higher. Biochemical shifts were revealed in the background of certain morphological changes of platelets. Possible pathophysiological mechanisms of the detected changes are discussed in the article. Conclusion. Active blood donation is accompanied by significant changes in the morphological parameters of platelets and the content of free serotonin in peripheral blood platelets. Further study of platelet hematopoiesis of active blood donors is required

scholarly journals Type A7 Coxsackie (type 4 poliomyelitis) virus infection in Scotland

1962 ◽  
Vol 60 (3) ◽  
pp. 323-332 ◽  
Author(s):  
N. R. Grist
Keyword(s):  
Tissue Culture ◽  
Blood Transfusion ◽  
Virus Infection ◽  
Technical Assistance ◽  
Animal Experiments ◽  
Rapid Identification ◽  
National Institutes Of Health ◽  
Reference Laboratory ◽  
Blood Transfusion Service ◽  
The Many

Coxsackie A 7 virus was isolated from thirty-seven patients during an outbreak in Scotland in 1959. Seven cases were paralytic, one of them fatal. Evidence is presented that Coxsackie A 7 virus caused these paralytic illnesses. The virus was also isolated from a paralytic case in 1956 and from a non-paralytic case in 1961. Serological surveys suggest that it has been active in the community for some years. Specific haemagglutination by Coxsackie A 7 virus was useful for rapid identification of viruses and for measurement of serum antibodies.I am grateful to Dr A. D. Macrae of the Virus Reference Laboratory, Colindale, London, for prototype Coxsackie A 7 virus; to Dr K. Habel of the National Institutes of Health, Bethesda, U.S.A., for tissue culture-adapted ABIV virus; to Dr J. Wallace of the Blood Transfusion Service, West of Scotland Region, for samples of blood donor sera; to Dr M. Rentsch, Klinik für Kinderkrankheiten, University of Berne, Switzerland, for permission to quote the results of virological tests of his cases; to Miss R. McLelland, F.A.T.A., and to Mr C. McLean F.I.M.L.T., for technical assistance with animal experiments; to Mr H. G. Carson, F.I.M.L.T. and to Mr J. Kerr, A.I.M.L.T., for technical assistance with neutralization tests; and to the many clinical colleagues who provided specimens and information for this study.

Study of viral safety of Scottish National Blood Transfusion Service factor VIII/IX concentrate

1993 ◽  
Vol 3 (4) ◽  
pp. 295-298 ◽  
Author(s):  
B. Bennett ◽  
A. A. Dawson ◽  
B. S. Gibson ◽  
A. Hepplestone ◽  
G. D. O. Lowe ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Factor Viii ◽  
Service Factor ◽  
Viral Safety ◽  
Blood Transfusion Service

Abstract TP402: Sickle Cell Disease in Pediatric Stroke - Inpatient Resource Utilization in the Decade Following STOP

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
J. Michael Taylor ◽  
Paul Horn ◽  
Heidi Sucharew ◽  
Todd A Abruzzo ◽  
Jane Khoury
Keyword(s):  
Sickle Cell Disease ◽  
Blood Transfusion ◽  
Sickle Cell ◽  
Care Utilization ◽  
Cell Disease ◽  
Common Procedure ◽  
Transfusion Therapy ◽  
Stroke Population ◽  
Clinical Classification Software ◽  
Inpatient Database

Background: Sickle cell disease (SCD) is an important risk factor for stroke in children. Natural history studies demonstrate that greater than 10% of hemoglobin SS patients suffered ischemic stroke prior to age 20 years. In 1998, the Stroke Prevention Trial in Sickle Cell Anemia (STOP) successfully demonstrated the role for routine transfusion therapy in reducing stroke in at risk SCD patients. Fullerton and colleagues then found that first time stroke in SCD decreased in Californian children in the 2 years following STOP. We investigated the stroke rate and health care utilization of children with SCD for two calendar years in the decade following publication of the STOP trial using a national inpatient database. Methods: The 2000 and 2009 Kids’ Inpatient Database (KID) were used for analysis. SCD and stroke cases were identified by ICD-9 codes 282.6x, 430, 431, 432.9, 434.X1, 434.9, 435.9. We queried the KID procedural clinical classification software for utilization of services pertinent to SCD and stroke; transfusion, MRI, and cerebral angio. Results: In 2000, SCD was a discharge diagnosis in 34,294 children and 158 (0.46%) children had SCD and stroke. By 2009, discharges with SCD rose to 37,082 children with 212 (0.57%) children carrying both diagnoses. In 2000 and 2009, AIS is the most common stroke type at 83%, males account for 53% of stroke and black race was reported by 92% of SCD and stroke subjects. Procedure utilization is higher in the SCD and stroke population than in SCD without stroke (Figure 1). Blood transfusion is the most common procedure in both study years, significantly higher in stroke subjects. Conclusion: For pediatric inpatients with SCD, blood transfusion and diagnostic cerebrovascular procedures were significantly more common in the cohort with comorbid stroke. In the decade after STOP, children hospitalized with SCD and stroke represented less than 0.6% of the total inpatient SCD population.

Retinal microvascular analysis using Fundus Fluorescein Angiography in Egyptian sickle cell disease patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Nayera H El Sherif ◽  
Mahmoud A Kenny ◽  
Waheed S Elhalfawy
Keyword(s):  
Sickle Cell Disease ◽  
Blood Transfusion ◽  
Fluorescein Angiography ◽  
Sickle Cell ◽  
Large Sample Size ◽  
Cell Disease ◽  
Fundus Fluorescein Angiography ◽  
Transfusion Therapy ◽  
Hydroxyurea Treatment ◽  
Trans Cranial Doppler

Abstract Background Sickle cell disease can affect retina of eye via vaso-occulsive changes that occur in micro-vessels of retina which could be analysed by using Fundus Fluorescein Angiography. Aim To analyze macular microvascular alternation in patients with SCD by Fundus Fluorescein Angiography (FFA) and to assess the role of potentially contributory Clinico-pathological factors including Trans-Cranial Doppler, genotypes, hydroxyurea, transfusion therapy and finally iron overload state on the development of macular alterations. Method This was across-sectional study which included 30 Sickle cell disease patients randomly recruited from the Paediatric Haematology clinic, children Hospital, Ain Shams University, Cairo, Egypt. Complete blood count (CBC), Trans-Cranial Doppler (TCD) and Fundus Fluorescein Angiography. Results In our study, there were 30 patients with mean age (14.1± 4.02), 5 patients had abnormal/conditional Trans-Cranial, 15 patients had Vaso-occlusive crises, 11 patients were on regular simple blood transfusion; all 30 studied sickle cell disease patients had normal Fundus Fluorescein Angiography and eye examination and only one patient hadabnormal visual acuity;A 29 years oldgirl who had five attacks of cerebral strokes last year, on regular simple blood transfusion and Hydroxyurea treatment with abnormal TCD and recurrent Vaso-occlusive crises in last two years, Although her vision is hand movement yet Fundus Fluorescein Angiography was normal. Conclusion we didn’t find any Retinal microvascular alternation in our studied SCD patients using Fundus Fluorescein Angiography, we related our results to the fact that our studied SCD patients were young and all our studied patients were on hydroxyurea therapy with fair compliance, further studies using large sample size are warranted in order to illustrate the utility of Fundus Fluorescein Angiography (FFA) as a tool for better detection of sickle retinopathy.

scholarly journals Myth: Blood transfusion is effective for sickle cell anemia—associated priapism

CJEM ◽  
2006 ◽  
Vol 8 (02) ◽  
pp. 119-122 ◽  
Author(s):  
Andrew L. Merritt ◽  
Christopher Haiman ◽  
Sean O. Henderson
Keyword(s):  
Blood Transfusion ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Conventional Therapy ◽  
Case Reports ◽  
Complete Information ◽  
Effective Therapy ◽  
Transfusion Therapy ◽  
Medline Search ◽  
Neurologic Sequelae

ABSTRACTObjective:Priapism is a recognized complication of sickle cell anemia (SCA). When initial conventional treatments fail, simple or exchange blood transfusion has been advocated as a secondary intervention. However, recent literature suggests this may not be an effective therapy and may have significant neurologic sequelae. This paper reviews and summarizes the effectiveness and risks of blood transfusion compared with conventional priapism therapy.Methods:All relevant papers identified from a MEDLINE search were systematically examined for data related to the use of blood transfusion in the setting of priapism due to SCA. The effectiveness of conventional therapy was compared with transfusion therapy using the outcome of “time to detumescence” (TTD). In addition, papers documenting adverse neurologic sequela were reviewed and summarized.Results:Forty-two case reports were identified containing complete information with regard to patient age and TTD. The mean TTD was 8.0 days with conventional therapy (n= 16) and 10.8 days with blood transfusion therapy (n= 26). Adverse neurologic sequelae from blood transfusion therapy was described in 9 cases, with long term outcomes ranging from complete resolution to severe residual deficits.Conclusion:The current literature does not support the contention that blood transfusion is an effective therapy in the treatment of priapism due to SCA, as defined by an acceleration of TTD. In fact, numerous reports suggest that serious neurologic sequelae may result from this treatment. We feel the routine use of this therapy cannot be recommended.

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