scholarly journals The relationship between antigen level in the middle ear and round window membrane permeability in antigen induced otitis media.

1988 ◽  
Vol 91 (11) ◽  
pp. 1864-1870
Author(s):  
YUKIYOSHI HAMAGUCHI ◽  
YASUO SAKAKURA
Keyword(s):  
Membrane Permeability ◽  
Otitis Media ◽  
Middle Ear ◽  
Round Window ◽  
Round Window Membrane ◽  
Antigen Level ◽  
The Relationship

Round Window Membrane in Serous and Purulent Otitis Media: Structural Study in the Rat

1993 ◽  
Vol 102 (3) ◽  
pp. 227-235 ◽  
Author(s):  
Ulf Johansson ◽  
Sten Hellström ◽  
Matti Anniko
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Structural Changes ◽  
Round Window ◽  
Inflammatory Cells ◽  
Elastic Fibers ◽  
Round Window Membrane ◽  
Connective Tissue Layer ◽  
Structural Alterations ◽  
Inflammatory Conditions

The rat was used as an animal model to reveal structural alterations in the round window membrane (RWM) during serous otitis media (SOM) and purulent otitis media (POM) over a 6-week period. Comparison of POM animals and control animals showed that the RWM in the former became almost six times as thick as that in controls, whereas that of SOM animals was twice as thick. The structural changes in the RWM in POM animals were confined mainly to the epithelium facing the middle ear cavity and the subepithelial space, which was invaded by inflammatory cells and exhibited dilated vessels. The normal flat epithelium was transformed via cuboidal cells to a cylindric epithelium containing both ciliated and goblet cells. In SOM animals, light microscopy revealed only minor changes in the RWM structure. Ultrastructurally, however, the connective tissue layer exhibited dense aggregations of collagen, increased numbers of fibroblasts, and, in one case, elastic fibers. This last phenomenon was not observed in either POM ears or normal ears. The study showed that various inflammatory conditions of the middle ear, both noninfectious (SOM) and infectious (POM), can cause different structural alterations of the RWM. These structural changes may influence passage through the RWM differently.

Round Window Membrane and Perilymph in Experimental Otitis Media with Effusion

1989 ◽  
Vol 98 (12) ◽  
pp. 980-987 ◽  
Author(s):  
Masashi Suzuki ◽  
Tatsuya Fujiyoshi ◽  
Hideyuki Kawauchi ◽  
Goro Mogi
Keyword(s):  
Otitis Media ◽  
Normal Control ◽  
Middle Ear ◽  
Immune Complexes ◽  
Otitis Media With Effusion ◽  
Round Window ◽  
Round Window Membrane ◽  
Prostaglandin E ◽  
The Mean ◽  
Ear Effusion

To investigate the influence of middle ear effusion (MEE) on perilymph (PL), an experimental otitis media with effusion (OME) was manufactured in chinchillas by injecting the tympanic cavity with immune complexes. The presence of MEE lasted for up to 9 days after the injection of immune complexes. Perilymph was aspirated on the fourth, tenth, and 21st days after the inoculation. The mean concentrations of albumin, immunoglobulin G, histamine, and prostaglandin E2 (PGE2) were significantly greater in PL from ears with induced OME than in that from normal control ears. The 3H-PGE2 placed on the round window membrane of pathologically affected ears passed into PL in significantly greater amounts than in normal control ears. The findings indicate that the immune complexes placed in the middle ear cavity affect the biochemical milieu of PL, and that MEE is a result of immune complexes.

Role of the Round Window Membrane in Middle Ear Immune Responses

1988 ◽  
Vol 105 (sup457) ◽  
pp. 139-143 ◽  
Author(s):  
E. M. Keithley ◽  
A. F. Ryan ◽  
J. P. Harris
Keyword(s):  
Immune Responses ◽  
Middle Ear ◽  
Round Window ◽  
Round Window Membrane

Inner Ear Pathology and Otitis Media

1980 ◽  
Vol 89 (3_suppl) ◽  
pp. 249-253 ◽  
Author(s):  
Michael M. Paparella ◽  
Marcos V. Goycoolea ◽  
William L. Meyerhoff
Keyword(s):  
Inner Ear ◽  
Otitis Media ◽  
Round Window ◽  
Round Window Membrane

Insidious inner ear complications of otitis media have been and are being studied in our laboratory. The purpose of this paper is to review these studies, coordinate, capsulize and highlight the results with emphasis on the transport role of the round window membrane.

Review of Round Window Membrane Permeability

1988 ◽  
Vol 105 (sup457) ◽  
pp. 43-48 ◽  
Author(s):  
Steven K. Juhn ◽  
Yukiyoshi Hamaguchi ◽  
Marcos Goycoolea
Keyword(s):  
Membrane Permeability ◽  
Round Window ◽  
Round Window Membrane

Simulation of Pathological High Impedance Tympanograms

1986 ◽  
Vol 29 (4) ◽  
pp. 505-514 ◽  
Author(s):  
Karel J. Van Camp ◽  
Janet E. Shanks ◽  
Robert H. Margolis
Keyword(s):  
Tympanic Membrane ◽  
Otitis Media ◽  
Middle Ear ◽  
High Frequency ◽  
Secretory Otitis Media ◽  
High Impedance ◽  
The Relationship

The Vanhuyse, Creten, and Van Camp (1975) model for analyzing high frequency tympanograms predicts the shapes of conductance, susceptance, and admittance tympanograms from the relationship between resistance and reactance tympanograms at the tympanic membrane. This model has been applied primarily to low impedance middle-ear pathologies but has not been applied extensively to the more commonly occurring high impedance pathologies. The purpose of this study was to extend the Vanhuyse et al. (1975) model to high impedance pathologies and to identify tympanometric parameters associated with otosclerosis, secretory otitis media, and lateral ossicular fixation. Data from previous experiments on the shape and absolute values of resistance and reactance tympanograms were used to calculate 678-Hz admittance tympanograms that were unique to each of the three high impedance pathologies. Guidelines for differentiating among the middle-ear pathologies on the basis of high frequency tympanometric shapes are presented.

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