Design and Synthesis of a Conformationally Restricted Analogue of the EFGH-Ring System of Ciguatoxin

Heterocycles ◽  
2009 ◽  
Vol 79 (1) ◽  
pp. 325 ◽  
Author(s):  
Masayuki Inoue ◽  
Masahiro Hirama ◽  
Nayoung Lee
Keyword(s):  
Ring System ◽  
Conformationally Restricted ◽  
Design And Synthesis

Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design

2004 ◽  
Vol 14 (9) ◽  
pp. 2041-2046 ◽  
Author(s):  
Lichun Sun ◽  
Natalya I Vasilevich ◽  
Joseph A Fuselier ◽  
Simon J Hocart ◽  
David H Coy
Keyword(s):  
Ring System ◽  
Conformationally Restricted

Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogs of angiotensinogen

1988 ◽  
Vol 31 (2) ◽  
pp. 284-295 ◽  
Author(s):  
Hing L. Sham ◽  
Giorgio Bolis ◽  
Herman H. Stein ◽  
Stephen W. Fesik ◽  
Patrick A. Marcotte ◽  
...  
Keyword(s):  
Renin Inhibitors ◽  
Conformationally Restricted ◽  
Design And Synthesis ◽  
New Class ◽  
Conformationally Restricted Analogs

Design and Synthesis of Side-Chain Conformationally Restricted Phenylalanines and Their Use for Structure-Activity Studies on Tachykinin NK-1 Receptor

1994 ◽  
Vol 37 (11) ◽  
pp. 1586-1601 ◽  
Author(s):  
Hubert Josien ◽  
Solange Lavielle ◽  
Alie Brunissen ◽  
Monique Saffroy ◽  
Yvette Torrens ◽  
...  
Keyword(s):  
Side Chain ◽  
Conformationally Restricted ◽  
Design And Synthesis ◽  
Structure Activity

1,2,3-Trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors

1992 ◽  
Vol 35 (10) ◽  
pp. 1710-1721 ◽  
Author(s):  
Stephen F. Martin ◽  
Richard E. Austin ◽  
Christopher J. Oalmann ◽  
William R. Baker ◽  
Stephen L. Condon ◽  
...  
Keyword(s):  
Renin Inhibitors ◽  
Conformationally Restricted ◽  
Design And Synthesis ◽  
Peptide Isosteres

scholarly journals Targetable Conformationally Restricted Cyanines Enable Photon-Count Limited Applications

2021 ◽  
Author(s):  
Patrick Eiring ◽  
Ryan McLaughlin ◽  
Siddharth Matikonda ◽  
HAN ZHONGYING ◽  
Lennart Grabenhorst ◽  
...  
Keyword(s):  
Single Molecule ◽  
Fluorescence Lifetime ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Ring System ◽  
Fluorescence Lifetime Imaging ◽  
Conformationally Restricted ◽  
Lifetime Imaging ◽  
Tertiary Amide ◽  
Imaging Performance

Cyanine dyes are exceptionally useful probes for a range of fluorescence-based applications. We recently demonstrated that appending a ring system to the pentamethine cyanine ring system improves the quantum yield and extends the fluorescence lifetime. Here, we report an optimized synthesis of persulfonated variants that enable efficient labeling of nucleic acids and proteins. We demonstrate that a bifunctional sulfonated tertiary amide significantly improves the optical properties of the resulting bioconjugates. These new conformationally restricted cyanines are compared to parent species in a range of contexts including their use on a DNA-nano-antenna, in single-molecule Förster resonance energy transfer (FRET) applications, far-red fluorescence lifetime imaging microscopy (FLIM), and single-molecule localization microscopy. These efforts define contexts in which eliminating cyanine isomerization provides meaningful benefits to imaging performance.

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