scholarly journals Effect of amlodipine on cardiovascular dynamic in exercise test in essential hypertension patient.

Author(s):  
YASUMASA TOYODA
2019 ◽  
Vol 2 (30) ◽  
pp. 37-40
Author(s):  
O. V. Zimnitskaya ◽  
M. M. Petrova

The clinical case of essential hypertension patient pharmacotherapy using the combination of olmesartan with lercanidipine was described in the article. The authors evaluated the effect of this combination not only on the degree of lowering blood pressure, but also on the levels of markers of endothelial dysfunction such as sPECAM-1 and copeptin. Pharmacotherapy with this combination of medicines was carried out for 28 weeks. It was found that in this patient the combination of olmesartan with lercanidipine led to the achievement of the blood pressure target level and decrease the level of sPECAM-1 by 2.5 times, and the level of copeptin by 5 times compared with the initial levels before treatment. Thus, the authors concluded that the combination of olmesartan and lercanidipine not only leads to the normalization of blood pressure, but also reduces the severity of endothelial dysfunction, which underlies the pathogenesis of essential hypertension.


Author(s):  
T. Wongso ◽  
Dewi LS ◽  
Z. Lubis

Increasing of urine albumin excretion in hypertension patient is early sign of renal excretion disorder. Increasing of urine albuminexcretion could not detect with conventional methods, but with more sensitive methods, one of them is examined ratio of urine albuminand urine creatinine (ACR). Knowing ACR rate in essential hypertension. This research was done by cross sectional with consecutivesampling of hypertension patient with JNC VII 2003 criteria. Research used quantitative urine albumin with Albumin Tina QuantMethods draught Immunoturbidinetry. The urine creatinine was analyzed with Jaffe Methods using Roche Hitachi 902. From 25 peopleof hypertension group found ACR < 30 mg/g amount 16 people and ACR rate 30–300 mg/g amount 9 people. Mean while from 22people of non hypertension, all had ACR < 30 mg/g. In this research also found strong correlation between ACR with hypertension,diastolic and systolic blood pressure. It was found that ACR rate of hypertension group was higher than the non hypertension group. Itwas also found a strong relation between ACR with hypertension, systolic and blood diastolic pressure.


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