Personalized Medicine in the Era of Genomics

2016 ◽  
pp. 296-327 ◽  
Author(s):  
Navneet Kaur Soni ◽  
Nitin Thukral ◽  
Yasha Hasija
Keyword(s):  
Clinical Practice ◽  
Personalized Medicine ◽  
Environmental Factors ◽  
Human Genome ◽  
High Throughput ◽  
Genome Analysis ◽  
Human Genome Project ◽  
Clinical Information ◽  
Genome Project ◽  
Genetic Makeup

Personalized medicine is a model that aims at customizing healthcare and tailoring medicine according to an individual`s genetic makeup. It classifies individuals that differ in their susceptibility to a particular disease or response to a particular treatment into subpopulations based on individual's unique genetic and clinical information along with environmental factors. The completion of Human Genome Project and the advent of high-throughput genome analysis tools has helped in building and strengthening this model. There lies a huge potential in the implementation of personalized medicine to significantly improve the clinical outcomes; however, its implementation into clinical practice remains slow and is a matter of concern. This chapter aims at acquainting readers with the underlying concepts and components of personalized medicine supplemented with some disease-based case studies, discussing challenges and recent advancements in the implementation of the model of personalized medicine.

scholarly journals Personalized Medicine in the Era of Genomics

2017 ◽  
pp. 297-327
Author(s):  
Navneet Kaur Soni ◽  
Nitin Thukral ◽  
Yasha Hasija
Keyword(s):  
Clinical Practice ◽  
Personalized Medicine ◽  
Environmental Factors ◽  
Human Genome ◽  
High Throughput ◽  
Genome Analysis ◽  
Human Genome Project ◽  
Clinical Information ◽  
Genome Project ◽  
Genetic Makeup

Personalized medicine is a model that aims at customizing healthcare and tailoring medicine according to an individual`s genetic makeup. It classifies individuals that differ in their susceptibility to a particular disease or response to a particular treatment into subpopulations based on individual's unique genetic and clinical information along with environmental factors. The completion of Human Genome Project and the advent of high-throughput genome analysis tools has helped in building and strengthening this model. There lies a huge potential in the implementation of personalized medicine to significantly improve the clinical outcomes; however, its implementation into clinical practice remains slow and is a matter of concern. This chapter aims at acquainting readers with the underlying concepts and components of personalized medicine supplemented with some disease-based case studies, discussing challenges and recent advancements in the implementation of the model of personalized medicine.

DNA Microarrays

2009 ◽  
pp. 278-293 ◽  
Author(s):  
Aristotelis Chatziioannou ◽  
Panagiotis Moulos
Keyword(s):  
Statistical Analysis ◽  
Human Genome ◽  
High Throughput ◽  
Human Genome Project ◽  
Dna Microarrays ◽  
Technological Development ◽  
Genome Project ◽  
Biological Processes ◽  
Microarray Image ◽  
The Human Genome Project

The completion of the Human Genome Project and the emergence of high-throughput technologies at the dawn of the new millennium, are rapidly changing the way we approach biological problems. DNA microarrays represent a promising new technological development, widely used for the investigation and identification of genes associated with important biological processes. The chapter is divided in two parts: the first discusses current methods for the acquisition and quantitation of the microarray image while the second focuses in the analysis and interpretation of the microarray signals (standardization, normalization, statistical analysis etc.)

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